Phenomenological and Pharmacological Identity of Audiogenic-Sensitive State in Animals Treated with Methionine Sulfoximine and in Genetically Audiogenic-Seizure-Susceptible Animals

  • Juhn Wada
  • Hisao Ikeda


The phenomenon of sound-induced, or audiogenic, “seizure” has been recognized in mice, rats, guinea pigs, and rabbits. Evidence to date indicates that there are a variety of genetic situations, at least in the house mouse, predisposing to susceptibility to audiogenic seizures [1]. However, this phenomenon remains a biological curiosity uninterpreted so far in terms of fundamental biological concepts, in spite of the presence of about 600 research reports on this particular problem. We became interested in this particular phenomenon following our discovery of an audiogenic susceptibility of animals treated with methionine sulfoximine (MSI). This agent, the toxic principle of agenized flour, is of considerable neurobiological interest since it produces in some mammalian species a complex syndrome characterized by peculiar behavioral episodes and convulsive seizures associated with certain autonomic manifestations. Episodic running behavior (ERB) is the most characteristic and constant feature in MSI-treated animals. This episode begins with the obvious manifestation of fear or apprehension followed by flight or escape-like behavior with wild running, leaping, and jumping movements. Subsequently, the animal may develop either a stuporous catatonic state or generalized convulsions. During the past three years, our attention has been focused on the fact that a striking phenomenological similarity exists between some of the episodic behavioral manifestations of MSI-treated animals and genetically audiogenic-sensitive animals.


Status Epilepticus Genetic Determinant Convulsive Seizure Audiogenic Seizure Electrographic Seizure 
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© Plenum Press 1967

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  • Juhn Wada
  • Hisao Ikeda

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