Abstract
In our laboratory, we have for a number of years searched for ways of relating function to the biochemical development of the central nervous system [1, 2]. This approach was utilized very well for function (EEG) and neuroanatomy by Schadé [3] and for neurochemistry and neuroanatomy by Baxter, Schadé, and Roberts [4]. Since we were dissatisfied with the results of an attempt to correlate maturation of cortical EEG and amino-acid levels in young animals, we decided that a study of a functional system which has a clear-cut role and whose parts are readily available for rapid removal for chemical assay and for electrophysiological studies during the period of rapid postnatal development might give a more meaningful picture. The visual system in the rabbit offers such a convenient study. Our work with this system has started on the superior colliculi with measurements of the visual evoked potential, the biogenic amines, and the free-amino-acid content and will continue into histochemical studies. This paper is a preliminary report on the visual evoked potential, as a functional point of reference, and the changes in dopamine, norepinephrine, serotonin, glutamic acid, glutamine, GABA, aspartic acid, threonine, and alanine in the superior colliculi during development.
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References
Himwich, W.A., and Petersen, J.C.: Correlation of chemical maturation of the brain in various species with neurologic behavior, in Masserman, J. H. (editor): Biological Psychiatry, Vol. 1, Grune and Stratton, New York, 1959, pp. 2–16.
Himwich, W.A., Petersen, J.C., and Graves, J. P.: Correlation of neurologic development and chemical maturation, in Wortis, J. (editor): Recent Advances in Biological Psychiatry, Vol. 3, Grune and Stratton, New York, 1961, pp. 218–226.
Schadé, J.P.: Origin of the spontaneous electrical activity of the cerebral cortex, in Wortis, J. (editor): Recent Advances in Biological Psychiatry, Vol. 2, Grune and Stratton, New York, 1960, pp. 23–42.
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Baxter, C. F., Schade, J. P., and Roberts, E.: Maturational changes in cerebral cortex. II. Levels of glutamic acid decarboxylase, gamma-aminobutyric acid and some related amino acids, in Roberts, E., Baxter, C.F., Van Harreveld, A., Wiersma, C.A.C., Adey, W.R., and Killam, K. F. (editors): Inhibitions of the Nervous System and gamma-Aminobutyric Acid, Pergamon Press, London, 1960, pp. 213–220.
Bertler, A., Carlsson, A., and Rosengren, E.: A method for the fluorimetric determination of adrenaline and noradrenaline in tissues, Acta Physiol. Scand. 44: 273–292, 1958.
Carlsson, A., and Waldeck, B.: A fluorimetric method for the determination of dopamine (3-hydroxytyramine), Acta Physiol. Scand. 44: 293–298, 1958.
Bertler, A.: Effect of resperine on the storage of catechol amines in brain and other tissues, Acta Physiol. Scand. 51: 75–83, 1961.
Carlsson, A., and Lindqvist, M.: In-vivo decarboxylation of a -methyl DOPA and a -methyl metatyrosine, Acta Physiol. Scand. 54: 87–94, 1962.
Levin, E., Lovell, R.A., and Elliott, K.A.C.: The relation of gamma-aminobutyric acid to factor I in brain extracts, J. Neurochem. 7: 147–154, 1961.
Altman, J., and Malis, L. I.: An electrophysiological study of the superior colliculus and visual cortex, Exptl. Neurol. 5: 233–249, 1962.
Ellingson, R. J., and Wilcott, R.C.: Development of evoked responses in visual and auditory cortices of kittens, J. Neurophysiol. 23: 363–375, 1960.
Himwich, H. E., and Aprison, M. H.: The effect of age on cholinesterase activity of rabbit brain, in Waelsch, H. (editor): Biochemistry of the Developing Nervous System, Academic Press, New York, 1955, pp. 301–307.
Siou, C.: L’activité cholinesterasique dans les tubercules quadrijumeaux antérieurs au cours du développement post-natal chez le lapin, Arch. Anat. Microscop. Morphol. Exptl. 51: 287–324, 1962.
Hampson, J.L., Essig, C. F., McCauley, A., and Himwich, H. E.: Effects of di-isopropyl fluorophosphate (DFP) on electroencephalogram and cholinesterase activity, Electroencephalog. Clin, Neurophysiol. 2: 41–48, 1950.
Talwar, G. P., Chopra, S. P., Goel, B. K., and D’Monte, B.: Correlation of the functional activity of the brain with metabolic parameters. III. Protein metabolism of the occipital cortex in relation to light stimulus, J. Neurochem. 13: 109–116, 1966.
Häggendal, J., and Malmfors, T.: Identification and cellular localization of the catecholamines in the retina and the choroid of the rabbit, Acta Physiol. Scand. 64: 58–66, 1965.
Drujan, B. D., Borges, J. M. D., and Alvarez, N.: Relationship between the contents of adrenaline, noradrenaline and dopamine in the retina and its adaptational state, Life Sci. 4: 473–477, 1965.
Utley, J. D.: Acetylcholinesterase and pseudo-cholinesterase in neural and non-neural tissue in the medial geniculate body of the cat, Biochem. Pharmacol. 15: 1–6, 1966.
Volokhov, A.A., and Shilyagina, N.N.: Ontogenic development of function in cortical and subcortical parts of visual system, Zh. Evolyutsionnoi Biokhim. Fiziol. 1:84, 1965; Fed. Proc. 25 (2): T221 - T226, 1966.
Garrigan, O.W., and Chargaff, E.: Studies on the mucolipids and the cerebrosides of chicken brain during embryonic development, Biochem. Biophys. Acta 70: 452–464, 1963.
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Himwich, W.A., Davis, J.M., Agrawal, H.C. (1967). Biochemical Substrates for the Development of the Matured Evoked Potential. In: Wortis, J. (eds) Recent Advances in Biological Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8228-7_19
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DOI: https://doi.org/10.1007/978-1-4684-8228-7_19
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