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Biochemical Substrates for the Development of the Matured Evoked Potential

  • Williamina A. Himwich
  • Jimmie M. Davis
  • Harish C. Agrawal

Abstract

In our laboratory, we have for a number of years searched for ways of relating function to the biochemical development of the central nervous system [1, 2]. This approach was utilized very well for function (EEG) and neuroanatomy by Schadé [3] and for neurochemistry and neuroanatomy by Baxter, Schadé, and Roberts [4]. Since we were dissatisfied with the results of an attempt to correlate maturation of cortical EEG and amino-acid levels in young animals, we decided that a study of a functional system which has a clear-cut role and whose parts are readily available for rapid removal for chemical assay and for electrophysiological studies during the period of rapid postnatal development might give a more meaningful picture. The visual system in the rabbit offers such a convenient study. Our work with this system has started on the superior colliculi with measurements of the visual evoked potential, the biogenic amines, and the free-amino-acid content and will continue into histochemical studies. This paper is a preliminary report on the visual evoked potential, as a functional point of reference, and the changes in dopamine, norepinephrine, serotonin, glutamic acid, glutamine, GABA, aspartic acid, threonine, and alanine in the superior colliculi during development.

Keywords

Glutamic Acid Aspartic Acid Biogenic Amine Superior Colliculus Biochemical Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1967

Authors and Affiliations

  • Williamina A. Himwich
  • Jimmie M. Davis
  • Harish C. Agrawal

There are no affiliations available

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