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Etiology of the Stimulant Nature of the Schizophrenias

  • C. C. Pfeiffer
  • R. A. Beck
  • L. Goldstein
  • E. S. Neiss

Abstract

Because of the lack of homogeneity of the schizophrenias, it is extremely doubtful that a single metabolic defect will be found as the causative factor. An advantageous theory would allow a series of related biochemical findings to be correlated into a common behavioral effect with a variety of final biochemical end-products. In developing this thesis we shall attempt to establish three generalizations: (1) that prolonged stimulation whether it be physical, biochemical, or drug-induced will produce hallucinatory states; (2) that the chronic schizophrenic is in a state of overstimulation; and (3) that alkylation and, more specifically, methylation of the known biogenic amines which occur in the body may result in compounds with greater CNS-stimulant activity and greater lipid solubility. The prolonged stimulation produced by these substituted biogenic amines results in psychosis.

Keywords

Schizophrenic Patient Biogenic Amine Hippuric Acid Brain Wave Prolonged Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press 1967

Authors and Affiliations

  • C. C. Pfeiffer
  • R. A. Beck
  • L. Goldstein
  • E. S. Neiss

There are no affiliations available

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