Effects of LSD on Somatosensory and Visual Evoked Responses and on the EEG in Man

  • Charles Shagass


There have been many attempts to define brain mechanisms related to the dramatic behavioral changes elicited by lysergic acid diethyl-amide (LSD). As Chapman and Walter [1] have noted, electrophysiologic studies of LSD in experimental animals have yielded inconsistent results, probably due to species differences and variable experimental conditions. Similarly, methodological differences may account for variable findings of studies conducted in man, particularly when techniques of differing sensitivity have been used for analyzing the EEG. Neuro-physiologic investigations of LSD in man have also been of limited scope, usually being confined to one kind of observation, e.g., EEG or evoked responses in one sensory modality.


Visual Response Amplitude Reduction Photic Stimulation Interval Histogram Evoke Response 
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© Plenum Press 1967

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  • Charles Shagass

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