Effects of LSD on Somatosensory and Visual Evoked Responses and on the EEG in Man

  • Charles Shagass


There have been many attempts to define brain mechanisms related to the dramatic behavioral changes elicited by lysergic acid diethyl-amide (LSD). As Chapman and Walter [1] have noted, electrophysiologic studies of LSD in experimental animals have yielded inconsistent results, probably due to species differences and variable experimental conditions. Similarly, methodological differences may account for variable findings of studies conducted in man, particularly when techniques of differing sensitivity have been used for analyzing the EEG. Neuro-physiologic investigations of LSD in man have also been of limited scope, usually being confined to one kind of observation, e.g., EEG or evoked responses in one sensory modality.


Visual Response Amplitude Reduction Photic Stimulation Interval Histogram Evoke Response 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Chapman, L. F., and Walter, R. D.: Action of lysergic acid diethylamide on averaged human cortical evoked responses to light flash, inWortis, J. (editor): Recent Advances in Biological Psychiatry, Plenum Press, New York, 1965, p. 23.Google Scholar
  2. 2.
    Elkes, J., Elkes, C., and Bradley, P.B.: The effect of some drugs on the electrical activity of the brain, and on behavior, J. Mental. Sci. 100: 125, 1954.Google Scholar
  3. 3.
    Gastaut, H., Ferrer, S., and Castells, C.: Action de la diéthylamide de l’acide d-lysergique (LSD 25) sur les fonctions psychiques et l’électroencephalogramme, Confinia Neurol. 13: 102, 1953.CrossRefGoogle Scholar
  4. 4.
    Anderson, E. W., and Rawnsley, K.: Clinical studies of lysergic acid diéthylamide, Monnatsschr. Psychiat. Neurol. 128: 38, 1954.CrossRefGoogle Scholar
  5. 5.
    Goldstein, L., Murphree, H.B., Sugarman, A.A., Pfeiffer, C.C., and Jenney, E.H.: Quantitative electroencephalographic analysis of naturally occurring (schizophrenic) and drug-induced psychotic states in human males, Clin. Pharmacol. Therap. 4: 10, 1963.Google Scholar
  6. 6.
    Burch, N. R.: Automatic analysis of the electroencephalogram: A review and classification of systems, Electroencephalog. Clin. Neurophysiol. 11: 827, 1959.CrossRefGoogle Scholar
  7. 7.
    Shagass, C., Schwartz, M., and Amadeo, M.: Some drug effects on evoked cerebral potentials in man, J. Neuropsychiat. 3: S49, 1962.Google Scholar
  8. 8.
    Shagass, C., and Schwartz, M.: Evoked potential studies iri psychiatric patients, Ann. N. Y. Acad. Sci. 112: 526, 1964.PubMedCrossRefGoogle Scholar
  9. 9.
    Shagass, C., and Schwartz, M.: Observations on somatosensory cortical reactivity in personality disorders, J. Nervous Mental Disease 135: 44, 1962.CrossRefGoogle Scholar
  10. 10.
    Eggert, D.C., and Shagass, C.: Clinical prediction of insightful response to a single large dose of LSD, Psychopharmacologia 9: 340, 1966.PubMedCrossRefGoogle Scholar
  11. 11.
    Shagass, C., Bittle, R. M., and Eggert, D.C.: Clinical prediction of therapeutic effects of LSD: A follow-up study, Proc. Fourth World Congress of Psychiatry, Madrid, 1966 (in press).Google Scholar
  12. 12.
    Schwartz, M., Emde, J., andShagass, C.:Comparison of constant current and constant voltage stimulators for scalp-recorded somatosensory responses, Electroencephalog. Clin. Neurophysiol. 17: 81, 1964.CrossRefGoogle Scholar
  13. 13.
    Emde, J.: A time locked low level calibrator, Electroencephalog. Clin. Neurophysiol. 16: 616, 1964.CrossRefGoogle Scholar
  14. 14.
    Shagass, C., and Schwartz, M.: Age, personality and somatosensory cerebral evoked responses, Science 148: 1359, 1965.PubMedCrossRefGoogle Scholar
  15. 15.
    Shagass, C., and Schwartz, M.: Visual cerebral evoked response characteristics in a psychiatric population, Am. J. Psychiat. 121: 979, 1965.PubMedGoogle Scholar
  16. 16.
    Lindquist, E. F.: Design and Analysis of Experiments in Psychology and Education, Houghton Mifflin, Boston, 1953.Google Scholar
  17. 17.
    Evarts, E. V.: Neurophysiological correlates of pharmacologically induced behavioral disturbances, Proc. Assoc. Res. Nervous Mental Disease 36: 347, 1958.Google Scholar
  18. 18.
    Fink, M., Shapiro, D. M., Hickman, C., and Itil, T • Quantitative analysis of the electroencephalogram by digital computer methods. III. Applications to psychopharmacology, read at VII IBM Medical Symposium, Poughkeepsie, N.Y., October 26, 1965.Google Scholar
  19. 19.
    Barlow, J. J.: Rhythmic activity induced by photic stimulation in relation to intrinsic alpha activity of the brain in man, Electroencephalog. Clin. Neurophysiol. 12: 317, 1960.CrossRefGoogle Scholar
  20. 20.
    Purpura, D.P.: Electrophysiological analysis of psychotogenic drug action. II. General nature of lysergic acid diethylamide (LSD) action on central synapses, Arch. Neurol. Psychiat. 75: 132, 1956.Google Scholar
  21. 21.
    Shagass, C. and Trusty, D.: Somatosensory and visual cerebral evoked response changes during sleep, in Wortis, J. (editor): Recent Advances in Biological Psychiatry, Plenum Press, New York, 1966, p. 321.Google Scholar

Copyright information

© Plenum Press 1967

Authors and Affiliations

  • Charles Shagass

There are no affiliations available

Personalised recommendations