Indices of Effectiveness of Treatment

  • Lawrence R. Freedman
Part of the Current Topics in Infectious Disease book series (CTID)


Evidence of clinical improvement after the institution of effective antibiotic treatment is usually not dramatic. Patients may have prompt normalization of temperature, in which case they might feel very much better quickly. On the other hand, although fever usually does subside within 2–4 days, this subsidence is gradual, and dramatic response is not the rule. Persistence of fever may indicate ineffective antibiotic therapy or a drug reaction. In some patients, persistent low-grade fever will continue as long as the patient receives antibiotics. Reappearance of fever after an afebrile interval may indicate embolization (pulmonary or arterial), infectious complications of prolonged intravenous therapy, reseeding of the bloodstream from a peripheral abscess, or drug reaction. Rarely, persistence of fever may be an indication of the presence of concomitant underlying disease such as lymphoma or myxoma.


Infective Endocarditis Neisseria Gonorrhoeae Serum Bactericidal Activity Endomyocardial Fibrosis Fungal Endocarditis 
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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Lawrence R. Freedman
    • 1
  1. 1.VA Wadsworth Medical CenterUCLA School of MedicineLos AngelesUSA

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