Establishment of Intravascular Infection

  • Lawrence R. Freedman
Part of the Current Topics in Infectious Disease book series (CTID)


Infection of susceptible intracardiac vegetations comes about by the deposition of bacteria circulating in the bloodstream on the surface of the vegetations. This mechanism is easily demonstrable in animals, and there is no evidence to support the older suggestion that bacteria arrive in the vegetations by way of the blood supply to the valve or endocardium. Studies of the early vegetations show clearly that colonization takes place from the edge of the vegetations. With the passage of time, older colonies, often containing microbial debris with metabolically less active forms, are found at the base of the vegetations.(1–3)


Aortic Valve Inferior Vena Cava Infective Endocarditis Prosthetic Valve Vascular Graft 
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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • Lawrence R. Freedman
    • 1
  1. 1.VA Wadsworth Medical CenterUCLA School of MedicineLos AngelesUSA

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