Vascular Smooth Muscle Reactivity in Hypoxia

  • J. Grote
  • G. Siegel


Arterial as well as tissue hypoxia induces vasodilation and a subsequent increase of blood flow in several organs [2,5,7,11,13]. In brain tissue regional blood flow increases significantly if the arterial oxygen falls below 60 mmHg. In the presence of hypoxia severe enough to cause anoxia in single cells, characteristic metabolic changes develop in cerebral cortex. Therefore, adjustment of the vascular system under these conditions is usually attributed to metabolic factors [9]. Among these K+, H+ ions, and adenosine seem to play an important role [2,7,13].


Smooth Muscle Membrane Potential Vascular Smooth Muscle Vascular Smooth Muscle Cell Oxygen Tension 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • J. Grote
    • 1
  • G. Siegel
    • 2
  1. 1.Institute of Physiology IUniversity of BonnBonn 1Germany
  2. 2.Institute of PhysiologyFree University of BerlinBerlin 33Germany

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