Brain Function, Pathophysiology and Heparin Therapy in Experimental Cerebral Sinus Vein Thrombosis

  • K. Frerichs
  • M. Deckert
  • O. Kempski
  • K. Einhäupl
  • A. Baethmann


Diagnosis of cerebral sinus vein thrombosis (SVT) is difficult to establish and, thus, rarely made by clinicians. For this reason it is frequently observed only at autopsy raising the suspicion that SVT often is a lethal disorder. Recent experience indicates, however, that SVT has a wide clinical spectrum reaching from discrete neurological deficits to most severe courses with coma [1]. Contrary to findings for arterial stroke, even severe neurological deficits arising from SVT have a likelihood of disappearing again. Due to the elusive nature and diagnostical problems of the disease, understanding of underlying mechanisms as well as therapeutical concepts are fragmentary and controversial. This may be attributable in part to the as yet limited experimental approaches and availability of animal models. To our knowledge, no experimental studies using small laboratory animals have been conducted so far for the investigation of pertinent functional and structural aspects of SVT. The current report analyzes functional parameters obtained in a new experimental model of SVT established by our group.


Sinus Thrombosis Spreading Depression Tissue Impedance Fluid Homeostasis Small Laboratory Animal 
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  1. 1.
    K. Einhäupl, Klinik und Pathophysiologie von blanden Hirnvenen-und Sinusthrombosen, Thesis, Ludwig-Maximilians-University, Munich (1986).Google Scholar
  2. 2.
    J. Bures, O. Buresova and J. Huston, eds., “Techniques and Basic Experiments for the Study of Brain and Behavior”, Elsevier Scientific Publishing, Amsterdam, pp 37–84 (1975).Google Scholar
  3. 3.
    C. P. Richter and G. H. Wang, New apparatus for measuring the spontaneous motility of animals, J. Lab. Clin. Med., 12: 289–292 (1926).Google Scholar
  4. 4.
    C. P. Richter, Animal behavior and internal drives, Quarterly Rev. Biol., Vol. II, No. 3 (1927).Google Scholar
  5. 5.
    B. F. Skinner, “Cerebral Blood Flow”e Behavior of Organisms-An Experimental Analysis”, Appelton-Century-Crofts Inc., New York (1936).Google Scholar
  6. 6.
    H. Künkel, Pharmaco-electroencephalography-methods and problems, in: “Pain Measurement in Man. Neurophysiological Correlates of Pain”, B. Bromm, ed., Elsevier Science Publishers BV, Amsterdam (1984).Google Scholar
  7. 7.
    I. Sulg, Quantitative EEG as a measure of brain dysfunction, in: “Brain Ischemia: Quantitative EEG and Imaging Techniques. Progress In Brain Research”, Vol. 62, G. Pfurtscheller, E.J. Jonkman and G. H. Lopes da Silva, Elsevier Science Publishers BV, Amsterdam (1984).Google Scholar
  8. 8.
    A. Baethmann, Das metabolische Hirnödem, Thesis, Ludwig-MaximiliansUniversity, Munich (1974).Google Scholar
  9. 9.
    A. Baethmann, Pathophysiological and pathochemical aspects of cerebral edema, Neurosurg. Rev., 1: 85–100 (1978).CrossRefGoogle Scholar
  10. 10.
    A. Baethmann, K. Maier-Hauff, O. Kempski, A. Unterberg, M. Lange and U. Gross, Hirnödem und Bewußtsein, Zeitschr. Allg. Med., 57: 2121–2126 (1981).Google Scholar
  11. 11.
    O. Kempski, Die Lokalisation des Glutamat-induzierten Hirnödems, Inauguraldissertation, Ludwig-Maximilians-University, Munich (1982).Google Scholar
  12. 12.
    I. Klatzo, Pathophysiological aspects of brain edema, Acta Neuropathol., 72: 236–239 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    D. J. K. Beck and D. Russell, Experiments on thrombosis of the superior longitudinal sinus, J. Neurosurg., 3: 337–347 (1946).PubMedCrossRefGoogle Scholar
  14. 14.
    G. Owens, G. Stahlman, J. Capps and A. Meirowsky, Experimental occlusion of durai sinuses, J. Neurosurg., 14: 640–647 (1957).PubMedCrossRefGoogle Scholar
  15. 15.
    K. Fujita, N. Kojima, N. Tamaki and S. Matsumoto, Brain edema in intracranial venous hypertension, in: “Brain Edema”, Y. Inaba, I. Klatzo and M. Spatz, eds., Springer, Berlin, pp 228–234 (1985).CrossRefGoogle Scholar
  16. 16.
    E. R. Heinz, D. Geeter and T.O. Gabrielsen, Cortical vein thrombosis in the dog with a review of aseptic intracranial venous thrombosis in man, Acta Radiol. Diagn., 13: 105–114 (1972).Google Scholar
  17. 17.
    S. Sato, Y. Miyahara, Y. Dohmoto, T. Kamase and S. Toya, Cerebral microcirculation in experimental sagittal sinus occlusion in dogs, in: ‘The Cerebral Veins“, L. M. Auer and F. Loew, eds., Springer, New York (1983).Google Scholar
  18. 18.
    M. Deckert, K. Frerichs, P. Mehraein, O. Kempski, A. Baethmann and K. Einhäupl, A new experimental model of sinus vein thrombosis, in: “Cerebral Sinus Thrombosis: Experimental and Clinical Aspects”, K. Einhäupl, O. Kempski and A. Baethmann, eds, Plenum Press, New York and London, pp 39–42 (1990).Google Scholar
  19. 19.
    D. D’Avella, R. P. Greenberg, S. Mingrino, M. Scanarini and K. Pardatscher, Alterations in ventricular size and intracranial pressure caused by sagittal sinus pathology in man, J. Neurosurg., 53: 656–661 (1980).PubMedCrossRefGoogle Scholar
  20. 20.
    A. Thron, K. Wessel, D. Linden, G. Schroth and J. Dichgans, Superior sagittal sinus thrombosis: neuroradiological evaluation and clinical findings, J. NeuroL, 233: 283–288 (1986).PubMedCrossRefGoogle Scholar
  21. 21.
    J. F. R. König and R. A. Klippel, “Cerebral Blood Flow”e Rat Brain. A Stereotaxic Atlas of the Fore-Brain and Lower Parts of the Brain Stem”, The Williams and Wilkins Company, Baltimore (1963).Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • K. Frerichs
    • 1
  • M. Deckert
    • 1
  • O. Kempski
    • 1
  • K. Einhäupl
    • 1
  • A. Baethmann
    • 1
  1. 1.Institute for Surgical Research and Department of NeurologyLudwig-Maximilians-University, Klinikum GroßhadernMunich 70Germany

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