Historical Perspectives on the Pathogenesis of Thrombosis in the Cerebral Veins and Sinuses
My invitation to contribute a chapter to this volume is based on an early communication on this fascinating topic which dates back to the days prior to the introduction of computed tomography (CT), magnetic resonance imaging (MRI) and even routine cerebral angiography . As a neurological resident my interest was roused by the admission of a 32-year-old patient comatose with neck stiffness, a third nerve palsy and grossly bloody cerebrospinal fluid. Assuming that the patient had suffered a ruptured posterior communication aneurysm, Canada’s pioneer neurosurgeon, Dr K. G. McKenzie, had performed an exploratory and negative craniotomy. At the time the patient was 10 days postpartum, and failed to survive the operation. At postmortem examination multiple sinus and vein thromboses were encountered with widespread areas of hemorrhagic infarction and gross blood within the subarachnoid space and the ventricles.
KeywordsSinus Thrombosis Cerebral Venous Thrombosis Cerebral Vein Carotid Artery Occlusion Hemorrhagic Infarction
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