Oxygen Transport Related Variables and Muscle Tissue Oxygenation in Critically Ill Patients with and Without Sepsis
Impaired tissue oxygenation and tissue hypoxia are considered to be the final common pathway of the various clinical insults that are responsible for the development of multiple systems organ failure (Sibbald et al., 1989). It was hypothesized that, in sepsis and ARDS patients tissue hypoxia may exist despite normal or even supranormal convective O2-transport to tissues by reduced O2 extraction capacity (Schumaker, Cain, 1987). In various clinical studies supply dependency of O2 uptake (VO2) has been demonstrated in patients with sepsis and ARDS (Danek et al., 1980, Mohsenifar et al., 1983, Bihari et al. 1987) which was interpreted as the indirect proof for the existance of a covert tissue hypoxia (Bihari et al., 1987). To test this hypothesis we compared variables related to hemodynamics- and oxygen transport — in two groups of critically ill patients.
KeywordsSeptic Shock Mean Arterial Pressure Pulmonary Capillary Wedge Pressure Tissue Hypoxia Adult Respiratory Distress Syndrome
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