Effects of Normobaric Hyperoxia on Hemodynamics and O2 Utilization in Conscious Dogs

  • R. F. Lodato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


It seems reasonable to speculate, as Priestley did in 1775 shortly after his discovery of oxygen, that breathing oxygen-enriched air at normal atmospheric pressure, or normobaric hyperoxia, might increase the overall rate of oxidative metabolism, according to the law of mass action. Indeed, the opposite may occur under resting conditions. Chapler, Cain, and Stainsby (1984) presented intriguing data in anesthetized dogs showing that hyperoxia can paradoxically decrease O2 consumption. More recently, Lodato (1989) has reported that whole-body O2 consumption is decreased during hyperoxia in intact conscious dogs. This paper briefly summarizes this latter work and, in addition, presents a new analysis of the relationship between O2 consumption and O2 transport during normobaric hyperoxia.


Extraction Ratio Oxyhemoglobin Saturation Normobaric Hyperoxia Left Ventricular Stroke Work Pulmonary Arterial Wedge Pressure 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • R. F. Lodato
    • 1
  1. 1.Division of Pulmonary Medicine and Critical CareUniversity of Texas Health Science CenterHoustonUSA

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