Effect of Long-Term Hypoxia on Oxygen Transport Properties of Blood in Pregnant Guinea Pigs

  • C. Geisen
  • K. Mottaghy
  • I. Scheffen
  • P. Kaufmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


Chronic hypoxia is associated with diverse and complex adaption mechanisms, including increases in haemoglobin and 2, 3-diphosphoglycerate (2,3-DPG) concentrations and tissue capillary density, as well as changes in cardiac output and other compensatory mechanisms (Kitanaka et al., 1988). During pregnancy adaptive physiological changes include increases in cardiac output, ventilation and oxygen consumption (Gilbert et al., 1979). Adjustment to hypoxia during pregnancy is complicated by the fact, that compensatory mechanisms have to insure a sufficient O2 supply to the maternal as well as the fetal organism. Placental O2 transfer depends on a number of factors, including the diffusion capacity of the placenta, the O2 status, the perfusion rate and morphology of uterine and umbilical vessels, furthermore the O2 affinity and O2 capacity of maternal as well as fetal blood (Christensen et al., 1986; Longo et al., 1972; Moll and Kastendieck, 1977)


Shear Rate Fetal Blood Hypoxic Animal Shear Flow Condition Prolonged Contact Time 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • C. Geisen
    • 1
  • K. Mottaghy
    • 1
  • I. Scheffen
    • 2
  • P. Kaufmann
    • 2
  1. 1.Dept. of Physiology, Medical FacultyTechnical University of AachenAachenGermany
  2. 2.Dept. of Anatomy, Medical FacultyTechnical University of AachenAachenGermany

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