Alterations in Intrauterine Oxygen Tension During the Estrous Cycle in the Rat and Hamster and Its Regulation by Ovarian Steroid Hormones: A Comparative Study
Previous studies have established that oxygen tension within the lumen of the uterus of the rat (Mitchell and Yochim, 1968a) and guinea pig (Garris and Mitchell, 1979) undergoes marked variation during the course of the normal estrous cycle. Such alterations are thought to result from the complex interplay of a number of physiologic and anatomic factors, including uterine blood flow, endometrial metabolism, and uterine structure. All of these determinants of intrauterine pO2 are directly influenced by fluctuations in endogenous ovarian steroid hormone levels. In order to gain further insight into the factors which regulate intrauterine oxygen tension, comparative studies have been undertaken in various species. The present report concerns observations made in the rat and hamster, specifically, the patterns of alteration in intrauterine pO2 observed during the normal estrous cycle and the effects of ovarian steroid deprivation and stimulation on oxygen tension within the lumen of the uterus.
KeywordsOxygen Tension Estrous Cycle Ovarian Steroid Uterine Blood Flow Venous Oxygen Tension
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