Redistribution of Local Hepatic Blood Flow during Acute Bleeding and Prolonged Hemorrhagic Hypotension Studied Using Fluorochromed Plasma Proteins and Surface Po2 Measurements

  • Michael Schywalsky
  • Hermann P. Metzger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


The degree and local distribution of morphological alterations occurring in the rat liver following hemorrhagic hypotension is influenced by a sequence of microcirculatory changes resulting in an increased heterogeneity of the microcirculatory perfusion pattern (Vanecko et al., 1969; Koo and Liang, 1977). On the other hand, morphological alterations develop during prolonged hemorrhagic hypotension which force changes in the hepatic microcirculation. Thus there exists a strong mutual relationship between changes in hepatic microcirculatory function and changes in hepatic parenchymal structure (Rappaport, 1976; Sherman and Fisher, 1987). Therefore it is necessary to distinguish between acute microcirculatory changes during the bleeding phase of hemorrhagic hypotension, and time dependent microcirculatory changes during prolonged hemorrhagic hypotension. In order to study the development and kinetics of sinusoidal flow heterogeneity during stepwise bleeding and during prolonged hemorrhagic hypotension, hepatic surface Po2 was measured and microcirculatory perfusion patterns were demonstrated by use of fluorochromed plasma proteins (Metzger and Schywalsky, 1988).


Mean Arterial Blood Pressure Perfusion Pattern Portal Field Hepatic Microcirculation Microcirculatory Change 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Michael Schywalsky
    • 1
  • Hermann P. Metzger
    • 1
  1. 1.Department of PhysiologyMedical School HannoverHannover 61Federal Republic of Germany

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