Advertisement

Significance of Cardiogenic Mixing in Dog Lungs

  • J. M. Schell
  • A. Rahmel
  • A. Schwalen
  • E. Calzia
  • M. Meyer
  • J. Piiper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

Since the early observations of DuBois et al. (1952) and of West and Hugh-Jones (1961) it has been known that the heart beat causes fluctuations of airway pressure. Variations of intrapulmonary pressure that occur synchronously with the heart beat were suggested to result from the cardiac motion itself or from cyclic changes of intrathoracic blood volume. Airflow variations caused by the beating heart in lobar and segmental bronchi have been determined in patients at bronchoscopy and found to occur asynchronously, flow increasing in one airway while decreasing in another (West and Hugh-Jones, 1961). The mechanisms underlying cardiogenic intrapulmonary gas flow, changes in heart volume or alterations in shape and position of the heart, are still controversial. Recent evidence suggests that the total heart volume remains essentially unchanged during the cardiac cycle (Hoffman and Ritman, 1985) and would therefore favour cyclic changes of shape and/or position of the heart causing airway pressure swings.

Keywords

Heart Beat Cardiac Action Beating Heart Heart Arrest Intrathoracic Blood Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Drechsler, D.M., Ultman, J.S., 1984, Cardiogenic mixing in the pulmonary conducting airways of man?. Respir. Physiol. 56: 37–44.PubMedCrossRefGoogle Scholar
  2. DuBois, A.B., Fowler, R.C., Soffer, A., Fenn, W.O., 1952, Alveolar CO2 measured by expiration into the rapid infrared gas analyzer. J. Appl. Physiol. 4: 526–534.PubMedGoogle Scholar
  3. Engel, L.A., 1983, Gas mixing within the acinus of the lung. J. Appl. Physiol. 54: 609–618.PubMedCrossRefGoogle Scholar
  4. Engel, L.A., Menkes, H., Wood, L.D.H., Utz, G., Joubert, J., Macklem, P.T., 1973a, Gas mixing during breath holding studied by intrapulmonary gas sampling. J. Appl. Physiol. 35: 9–17.PubMedGoogle Scholar
  5. Engel, L.A., Wood, L.D.H., Utz, G., Macklem, P.T., 1973b, Gas mixing during inspiration. J. Appl. Physiol. 35:18–24.PubMedGoogle Scholar
  6. Fukuchi, Y., Roussos, C.S., Macklem, P.T., Engel, L.A., 1976, Convection, diffusion and cardiogenic mixing of inspired gas in the lung:an experimental approach. Respir. Physiol. 26: 77–90.PubMedCrossRefGoogle Scholar
  7. Horsfield, K., Gabe, J., Mills, C., Buckman, M., Cumming, G., 1982, Effect of heart rate and stroke volume on gas mixing in dog lung. J. Appl. Physiol. 53: 1603–1607.PubMedGoogle Scholar
  8. Hoffman, E.A., Ritman, E.L., 1985, Invariant total heart volume in the intact thorax. Am. J. Physiol. 249: H883–H890.PubMedGoogle Scholar
  9. Jones, H.A., Chakrabarti, M.K., Davies, E.E., Hughes, J.M.B., Sykes, M.K., 1982, The contribution of heart beat to gas mixing in the lungs of dogs. Respir. Physiol. 50: 177–185.PubMedCrossRefGoogle Scholar
  10. Meyer, M., Hook, C., Rieke, H., Piiper, J., 1983, Gas mixing in dog lungs studied by single-breath washout of He and SF6. J. Appl. Physiol. 55: 1795–1802.PubMedGoogle Scholar
  11. Meyer, M., Slama, H., 1983, A versatile hydraulically operated respiratory servo system for ventilation and lung function testing. J. Appl. Physiol. 55:1023–1030.PubMedGoogle Scholar
  12. Piiper, J., Scheid, P., 1987, Diffusion and convection in intrapulmonary gas mixing. In: Handbook of Physiology. The Respiratory System. Gas Exchange. Bethesda, MD, Am. Physiol. Soc., sect. 3, vol IV, p. 51–69.Google Scholar
  13. West, J.B., Hugh-Jones, P., 1961, Pulsatile gas flow in bronchi caused by the heart beat J. Appl. Physiol. 16: 697–702.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. M. Schell
    • 1
  • A. Rahmel
    • 1
  • A. Schwalen
    • 1
  • E. Calzia
    • 1
  • M. Meyer
    • 1
  • J. Piiper
    • 1
  1. 1.Department of PhysiologyMax Planck Institute for Experimental MedicineGöttingenFederal Republic of Germany

Personalised recommendations