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Blood-Gas Transfer of O2 and CO2 in the Lungs: New Models Measurements and Conclusions

  • Masaji Mochizuki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

Three simultaneous differential equations for O2, CO2 and HCO 3 - diffusion in the red blood cell (RBC) were solved numerically, taking the Bohr and Haldane effects into account (Mochizuki and Kagawa, 1986). Then, from the numerical solution the relationship of the gas exchange ratio (R) to alveolar PCO2 (PACO2) during rebreathing was derived (Kagawa and Mochizuki, 1987). R in rebreathing air is linearly related to PACO2. Since CO2 diffusion in the RBC accompanies HCO 3 - shift and partly results from the Haldane effect, the CO2 reactions are generally slower than the O2 reactions. Therefore, the slope of R-CO2 line (θ) depends not only on the true venous PCO2 (trPvCO2) and arterial-venous O2 content difference (C(a-v)O2), but also on the contact time (tc). Using the theoretical equation for the R-PCO2 line as a gas exchange model, the relationship between tc and C(a-v)O2 is obtained from the experimental data of rebreathing in normal subject (Shibuya et al, 1987).

Keywords

Contact Time Dissociation Curve Content Difference Lung Capillary Pulmonary Diffuse Capacity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Fukui, K. and Mochizuki, M. Some basic problems on the pulmonary diffusing capacity for carbon monoxide. I. The reaction rate of CO with oxygenated hemoglobin in the red cell. Monogr. Ser. Res. Inst. Appl. Electr. Hokkaido Univ. 20, 69–78, 1972.Google Scholar
  2. Kagawa, T. and Mochizuki, M. Theoretical analyses for arterial-venous O2 content difference and Haldane effect during rebreathing. Jpn. J. Physiol., 37, 267–282, 1987.PubMedCrossRefGoogle Scholar
  3. Mochizuki, M., Shibuya, I., Uchida, K. and Kagawa, T. A method for estimating contact time of red blood cells through lung capillary from O2 and CO2 concentrations in rebreathing air in man. Jpn. J. Physiol. 37, 283–301, 1987.PubMedCrossRefGoogle Scholar
  4. Shibuya, I., Uchida, K. and Mochizuki, M. Experimental analyses of pulmonary gas exchange in a standing position at rest and during treadmill exercise. Jpn. J. Physiol. 37, 303–320, 1987.PubMedCrossRefGoogle Scholar
  5. Tazawa, H., Mochizuki, M., Tamura, M. and Kagawa, T. Quantitative analyses of the CO2 dissociation curve of oxygenated blood and the Haldane effect in human blood. Jpn. J. Physiol. 33, 601–618, 1983.PubMedCrossRefGoogle Scholar
  6. Uchida, K., Shibuya, I. and Mochizuki, M. Simultaneous measurement of cardiac output and pulmonary diffusing capacity for CO by a rebreathing method. Jpn. J. Physiol. 36, 657–670, 1986.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Masaji Mochizuki
    • 1
  1. 1.Geriatric Respiratory Research CenterNishimaruyama Hospital064 Sapporo/Chuo-KuJapan

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