Skeletal Muscle PO2 during Hypodynamic Sepsis

  • G. Gutierrez
  • N. Lund
  • F. Palizas
  • A. Acero
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


It has been hypothesized (Nelson et al., 1988, Samsel et al., 1988, Bredle et al. 1989), that sepsis is a disorder of microvascular regulation resulting in decreased O2 transport from the capillaries to the mitochondria. Evidence for this hypothesis was offered by Nelson et al. (1988), who found greater levels of systemic and intestinal critical O2 transport (TO2), defined as the minimum TO2 required to maintain constant O2 consumption (VO2), in hypovolemic septic dogs when compared to a control group. This phenomenon may be related to increases in microcirculatory heterogeneity, resulting in a mismatch of tissue perfusion and cellular O2 needs. This is manifested at the organ level by decreases in O2 extraction capacity.


Inferior Vena Cava Mean Arterial Blood Pressure Right Atrium Endotoxin Infusion Capillary Transit Time 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • G. Gutierrez
    • 1
  • N. Lund
    • 2
  • F. Palizas
    • 1
  • A. Acero
    • 1
  1. 1.Pulmonary and Critical Care DivisionUniversity of Texas Health Science CenterHoustonUSA
  2. 2.Department of AnesthesiologyThe University of Rochester Medical CenterRochesterUSA

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