Temperature Effect on Oxygenation and Metabolism of Perfused Rat Hindlimb Muscle

  • Akitoshi Seiyama
  • Takeshi Shiga
  • Nobuji Maeda
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


Temperature effect on tissue oxygenation and metabolism is a major concern to activity and/or viability of tissues. In an ischemic state, supplement of oxygen and nutrients is impaired and metabolites are accumulated, thus tissue damage is induced reversibly or irreversibly. This deterioration of tissue accompanied by ischemia is mediated by chemical reactions, and the rates are directly dependent upon temperature. Rat hindlimb is well suited for the optical measurement of biochemicals that participate in oxygen transport (Tamura et al., 1987; Seiyama et al., 1988) as well as the biochemical investigation on the integral function of skeletal muscle (Shiota et al., 1986).


Oxygen Tension Difference Spectrum Tissue Oxygen Tension Lactate Release Skeletal Muscle Mitochondrion 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Akitoshi Seiyama
    • 1
  • Takeshi Shiga
    • 2
  • Nobuji Maeda
    • 1
  1. 1.Department of Physiology, School of MedicineEhime UniversityOnsen-gun, EhimeJapan
  2. 2.Department of Physiology, Shool of MedicineOsaka UniversityKita-ku, Osaka 530Japan

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