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Tissue Oxygen Partial Pressure Distribution within the Human Skeletal Muscle during Hypercapnia

  • P. Boekstegers
  • M. Weiss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

The effects of arterial hypercapnia on the cardiovascular system have been extensively investigated. However, few data exist on the effects of hypercapnia on the peripheral circulation in man. In animal experiments the increase of the systemic sympathetic tone due to hypercapnia (Loeschke 1982, Pelletier 1972, Rose et al. 1983, Soladoye et al. 1985, Suutarinen 1966) elicited an increase in total peripheral resistance (Rose et al. 1983, Rothe et al. 1985). Stimulation of sympathetic nerves resulted in vasoconstriction of vascular beds which were constantly perfused with blood kept at a constant and physiological paO2, pCO2, and pH (Lioy et al. 1978, Pelletier 1972, Soladoye et al. 1985). However, vasodilation and an increase of blood flow occurred, if denervated vascular beds were perfused with hypercapnic blood (Daugherty et al. 1967). It is unknown, whether one of these apparently antasonistic effects of hypercapnia on vascular tone changes the peripheral blood flow to an extent that the oxygen delivery to the tissue could be impaired. In order to study the effects of hypercapnia on the oxygen offer to peripheral tissue in man, the distribution of local oxygen partial pressure (pO2-histogram) within the skeletal muscle was measured in healthy human volunteers during inhalation of a 6.5% carbon dioxide containing air mixture. In order to distinguish between effects on the pO2-histograms due to hypercapnia and the effects on the pO2-histograms due to a change of blood pH, the present study was performed with and without buffering the blood pH during carbon dioxide inhalation.

Keywords

Oxygen Partial Pressure Base Excess Total Peripheral Resistance Carbon Dioxide Tension Healthy Human Volunteer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boekstegers, P., Fleckenstein, W., Rosport, A., Ruschewsky, W. and Braun, U., 1988, Überwachung der Sauerstoffvers orgung des Skelettmuskels und der Gesamtsauerstoffaumahme bei koronarchirurgischen Eingriffen, Anaesthesist. 37: 287–296.PubMedGoogle Scholar
  2. Daugherty, R.M., Scott, J.B., Dabney, J.M., Haddy, F.J., 1967, Local effects of O2 and CO2 on limb, renal, and coronary vascular resistance, Am. J. Physiol., 213: 1102–1110.PubMedGoogle Scholar
  3. Cain, S.M., 1970, Increased oxygen uptake with passive hyperventilation of dogs, J. Appl. Physiol., 28: 4–7.PubMedGoogle Scholar
  4. Ehrly, A.M., Hauss, J. and Huch, R., 1987, Clinical oxygen pressure measurememt, Springer, Berlin Heidelberg New York.Google Scholar
  5. Karetzky, M.S. and Cain, M.S., 1970, Effect of carbon dioxide on oxygen uptake during hyperventilation in normal man, J. Appl. Physiol., 28: 8–12.PubMedGoogle Scholar
  6. Lioy, F., Hanna, B.D. and Polosa, C., 1978, CO2-dependent component of the neurogenic vascular tone in the cat, Pflügers Arch., 374: 187–191.PubMedCrossRefGoogle Scholar
  7. Loeschke, H.H., 1982, Central chemosensitivity and the reaction theory, Am. J. Physiol., 332: 1–24.Google Scholar
  8. Lund, N., Jorfeld, L. and Lewis, D.H., 1980, Skeletal muscle oxygen pressure fields in healthy human volunteers, Acta Anaesthesiol. Scand., 24: 272–281.PubMedCrossRefGoogle Scholar
  9. Pelletier, C.L., 1972, Circulatory responses to graded stimulation of the carotid chemoreceptors in the dog, Circ. Res., 31: 431–443.PubMedCrossRefGoogle Scholar
  10. Richardson, D.W., Wassermann, A.J. and Patterson, J.L., 1962, General and regional circulatory responses to change in blood pH and carbon dioxide tension, J. Clin. Invest., 40: 31–43.CrossRefGoogle Scholar
  11. Rose, C.E., Althaus, J.A., Kaiser, D.L., Miller, E.D. and Carey, R.M., 1983, Acute hypoxemia and hypercapnia: increase in plasma catecholamines in conscious dogs, Am. J. Physiol., 245: 924–929.Google Scholar
  12. Rothe, C.F., Stein, P.M., MacAnespie, C.L. and Gaddis, M.L., 1985, Vascular capacitance responses to severe systemic hypercapnia and hypoxia in dogs, Am. J. Physiol., 249: 1061–1069.Google Scholar
  13. Soladoye, A.O., Rankin, A.J. and Hainsworth, R., 1985, Influence of carbon dioxide tension in the cephalic circulation on hind-limb vascular resistance in anaesthetized dogs, J. Exp. Phvsiol., 70: 527–538.Google Scholar
  14. Suutarinen, T., 1966, Cardiovascular response to changes in arterial carbon dioxide tension: An experimental study on thoracotomized dogs, Acta Physiol. Scand., 67: Suppl 266.Google Scholar
  15. Weiss, Ch and Fleckenstein, W., 1986, Local tissue pO2 measured with “thick” needle probes, Funktionsanalyse biologischer Systeme 15: 155–166.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • P. Boekstegers
    • 1
  • M. Weiss
    • 1
  1. 1.Department of PhysiologyMedical University of LübeckLübeckGermany

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