Hypoxia Tolerance of Coronary Endothelial Cells
The coronary endothelium performs a great number of specific metabolic and physiological functions, e.g. the synthesis of autacoids, and the control of the transport of material into and out of the blood stream. For these performances a sufficient supply of metabolic energy is required. Alterations of the energetic state, e.g. due to an insufficient O2 supply, can lead to serious malfunctions and injury of endothelial cells, which thus can crucially contribute to ischemic myocardial damage.
KeywordsLactate Production Oxygen Consumption Rate Energetic State Hypoxia Tolerance Adenylate Energy Charge
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