Effect of Local Anaerobiosis on Heart Rate

  • Franz Thimm
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


Early occlusion experiments of legs showed that anaerobiosis combined with an accumulation of metabolites initiated an increase in the heart rate (Alam and Smirk, 1938; Stegemann, 1963). The authors concluded that this reflex was caused by metabolites which stimulated afferent nerve fibres. The connection between diminished oxygen supply and vegetative reactions has been demonstrated meanwhile by experiments in animals and in man, including exercise and training experiments (Bonde-Petersen et al., 1978; Barnas et al., 1986).


Heart Rate Respiratory Rate Metabolic Parameter Evans Blue Venous Outflow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Alam, M., and Smirk, F.H., 1938, Observation in man on a pulse-accelerating reflex from the voluntary muscles of the legs, J. Physiol., 92: 167.PubMedGoogle Scholar
  2. Barnas, G., Gleeson, M., and Rautenberg, W., 1986, Cardiorespiratory responses to hypoxia in intact and bilaterally vagotomized pigeons, J. Appl. Physiol., 61: 1340.PubMedGoogle Scholar
  3. Bonde-Petersen, F., Rowell, L.B., Murray, R.G., Blomqvist, C.G., White, R., Karlson, E., Campbell, W., and Mitchell, J.H., 1978, Role of cardiac output in the pressor responses to graded muscle ischemia in man, J. Appl. Physiol., 45: 547.Google Scholar
  4. Davies, C.M.T., Few, J., Foster, K.G., and Sargeant, A.J., 1974, Plasma catecholamine concentration during dynamic exercise involving different muscle groups, Eur. J. Appl. Physiol., 32: 195.CrossRefGoogle Scholar
  5. Hohorst, H.J., 1970, L(+)-Lactat. Bestimmung mit Lactat-Dehydrogenase und NAD, in: Methoden der enzymatischen Analyse, Vol. II, H.U. Bergmeyer, ed., Verlag Chemie, Weinheim.Google Scholar
  6. Kao, F.F., and Ray, L.H., 1954, Regulation of cardiac output in anesthetized dogs during muscular work, Am. J. Physiol., 179: 255.PubMedGoogle Scholar
  7. Kniffki, K.D., Mense, S., and Schmidt, R.F., 1978, Responses of group IV afferent units from skeletal muscle to stretch contraction and chemical stimulation, Exp. Brain Res., 31: 511.PubMedCrossRefGoogle Scholar
  8. Kniffki, K.D., Mense, S., and Schmidt, R.F., 1981, Muscle receptors with fine afferent fibers which may evoke circulatory reflexes. Circ. Res., 48: 125.Google Scholar
  9. Kumazawa, A., and Mizumura, K., 1977, Thin-fibre receptors responding to mechanical, chemical, and thermal stimulation in skeletal muscle of the dog, J. Physiol. (London), 273: 179.Google Scholar
  10. Leiner, B., 1986, “Einführung in die Zeitreihenanalyse”, 2nd edition, Oldenbourg-Verlag, München.Google Scholar
  11. McCloskey, D.I., and Mitchell, J.H., 1972, Reflex cardiovascular and respiratory responses originating in exercising muscle, J. Physiol. (London). 224: 173.Google Scholar
  12. Sreter, F.A., and Friedman, S.M., 1958, The effect of muscular exercise on plasma sodium and potassium in the rat, Can. J. Biochem. Physiol., 36: 333.PubMedCrossRefGoogle Scholar
  13. Stegemann, J., 1963, Zum Mechanismus der Pulsfrequenzeinstellung durch den Stoffwechsel I — IV, Pflügers Arch., 276: 481.CrossRefGoogle Scholar
  14. Steinhagen, C., Hirche, H.J., Nestle, H.W., Bovenkamp, U., and Hosselmann, J., 1976, The interstitial pH of working gastrocnemius muscle of the dog, Pflügers Arch., 367: 151.PubMedCrossRefGoogle Scholar
  15. Thimm, F., Carvalho, M., Babka, M., and Meier zu Verl, E., 1984, Reflex increase in heart rate induced by perfusing the hind leg of the rat with solution containing lactic acid, Pflügers Arch., 400: 288.CrossRefGoogle Scholar
  16. Thimm, F., and Baum, K., 1987, Response of chemosensitive nerve fibers of group ELI and IV to metabolic changes in rat muscles, Pflügers Arch., 410: 143.PubMedCrossRefGoogle Scholar
  17. Tibes, U., 1981, “Kreislauf und Atmung bei Arbeit und Sport”, Richarz, St. Augustin.Google Scholar
  18. Tibes, U., Hemmer, B., and Böning, D., 1977, Heart rate and ventilation in relation to venous [K+], osmolality, pH, Pco2, Po2 [orthophosphate], and [lactate] at transition from rest to exercise in athletes and non-athletes, Eur. J. Appl. Physiol., 36: 127.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Franz Thimm
    • 1
  1. 1.Physiologisches InstitutUniversität FreiburgFreiburgGermany

Personalised recommendations