Oxygen Dependence of Energy State and Cardiac Work in the Perfused Rat Heart
The effects of hypoxia can be observed by noting changes in the circulatory system and tissue metabolism. Theoretical and experimental studies (Sugano et al., 1974) have shown a dependence of mitochondrial oxidative phosphorylation on oxygen tension. Thus, a reduction in oxygen tension results in a decrease of energy production. To date, there have been few studies concerning the relation between cellular oxygen concentration and high energy phosphates in heart tissue (Fukuda et al., 1989).
KeywordsOxygen Tension Oxygen Gradient Cardiac Work High Energy Phosphate Oxygen Dependence
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- Caspary, L., Hoffmann, J., Ahmad, H. R., and Lubbers. D.W., 1985, Multicomponent analysis of reflection spectra from the guinea pig heart for measuring tissue oxygenation by quantitative determination of oxygen saturation of myoglobin and of the redox state of cytochrome aa 3, c, and b, Adv. Exp. Med. Biol. 191:263–270.PubMedCrossRefGoogle Scholar