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Oxygen Dependence of Energy State and Cardiac Work in the Perfused Rat Heart

  • Kinji Ito
  • Shoko Nioka
  • Britton Chance
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

The effects of hypoxia can be observed by noting changes in the circulatory system and tissue metabolism. Theoretical and experimental studies (Sugano et al., 1974) have shown a dependence of mitochondrial oxidative phosphorylation on oxygen tension. Thus, a reduction in oxygen tension results in a decrease of energy production. To date, there have been few studies concerning the relation between cellular oxygen concentration and high energy phosphates in heart tissue (Fukuda et al., 1989).

Keywords

Oxygen Tension Oxygen Gradient Cardiac Work High Energy Phosphate Oxygen Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kinji Ito
    • 1
  • Shoko Nioka
    • 1
  • Britton Chance
    • 1
  1. 1.The Department of Biochemistry and Biophysics, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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