Response Time of Mitochondrial Oxygen Consumption Following Stepwise Changes in Cardiac Energy Demand

  • J. H. G. M. van Beek
  • N. Westerhof
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


When the metabolic demand of the heart changes, the mitochondria alter their ATP-production which is linked to mitochondrial oxygen consumption. The control mechanisms of mitochondrial respiratory rate are under debate (Chance et al., 1986; Katz et al., 1989; Erecinska and Wilson, 1982). Knowledge of the time course of mitochondrial oxygen consumption following changes in ATP-hydrolysis could give important information on mitochondrial metabolic control mechanisms and adaptation to cellular energy demand.


Oxygen Uptake Rabbit Heart Perfusion Flow Stepwise Change Tyrode Solution 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. H. G. M. van Beek
    • 1
  • N. Westerhof
    • 1
  1. 1.Laboratory for PhysiologyFree UniversityAmsterdamThe Netherlands

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