Response Time of Mitochondrial Oxygen Consumption Following Stepwise Changes in Cardiac Energy Demand
When the metabolic demand of the heart changes, the mitochondria alter their ATP-production which is linked to mitochondrial oxygen consumption. The control mechanisms of mitochondrial respiratory rate are under debate (Chance et al., 1986; Katz et al., 1989; Erecinska and Wilson, 1982). Knowledge of the time course of mitochondrial oxygen consumption following changes in ATP-hydrolysis could give important information on mitochondrial metabolic control mechanisms and adaptation to cellular energy demand.
KeywordsOxygen Uptake Rabbit Heart Perfusion Flow Stepwise Change Tyrode Solution
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