Abstract
The purpose of this study is to evaluate reserves of O2 transport in myocardium using tachycardia as a stimulus. The O2 saturations of hemoglobin (Hb) in microvessels and myoglobin (Mb) in individual myocytes are the measured responses. The latter is of particular interest in that it represents the net balance of all determinants of O2 supply and demand.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bailey, J.R., and Driedzic, W.R., 1988, Perfusion-independent oxygen extraction in myoglobin-rich hearts, J. Exp. Biol., 135:301.
Balaban, R.S., Kantor, H.L., Katz, L.A., and Briggs, R.W., 1986, Relation between work and phosphate metabolites in the in vivo paced mammalian heart, Science. 232:1121.
Buckberg, D.D., Fixier, F.E., Archie, J.P., and Hoffman, J.E., 1972, Experimental subendocardial ischemia in dogs with normal coronary arteries, Circ. Res. 30:67.
Chuong, C.J., and Fung, Y.C., 1986, Residual stress in arteries, in: “Frontiers in Biomechanics.” G.W. Schmid-Schoenbein, S.L.-Y. Woo, and B.W. Zweifach, eds., Springer, New York.
Clark, A., Clark, P. A. A., Connett, R. J., Gayeski, T. E. J., and Honig, C. R., How large is the drop in PO2 between cytosol and mitochondrial? Am. J. Physiol., 252:C583, 1987.
Coburn, R. F., Ploegmakers, F., and Gondrii, P., and R. Abboud., 1973, Myocardial myoglobin O2 tension, Am. J. Physiol., 224:870.
Degner, F., and Gayeski, T. E. J., 1987, A comparison of a four wavelength analysis and multicomponent wavelength analysis applied to determination of hemoglobin saturation, Adv. Exper. Med. Biol., 215:153.
Federspiel, W. J., and Popel, A. S., 1986, A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries, Microvasc. Res., 32:164.
Gayeski, T. E. J., 1981, A Cryogenic Microspectrophotometric Method for Measuring Myoglobin Saturation in Subcellular Volumes; Application to Resting Dog Muscle, (Ph.D. Thesis), Rochester, NY: University of Rochester, Univ. Microfilms, No. DA9224720, Ann Arbor, MI.
Gayeski, T. E. J., and Honig, C.R., 1986, 02 gradients from sarcolemma to cell interior in a red muscle at maximal VO2, Am. J. Physiol., 251:789.
Gayeski, T. E. J., and Honig, C. R., 1989, Intracellular PO2 in individual cardiac myocytes in dog, cat, rabbit, ferret and rat, Am. J. Physiol., in press.
Gayeski, T.E.J., Connett, R.J., and Honig, C.R., 1987, The minimum intracellular PO2 for maximum cytochrome turnover in red muscle in situ. Am. J. Physiol., 252:H906.
Gray, L.H., and Steadman, J.M. 1964, Determination of the oxyhaemoglobin dissociation curves for mouse and rat blood, 175:161.
Groebe, K., and Thews, G., 1986, Theoretical analysis of oxygen supply to contracted skeletal muscle, Adv. Exper. Med. Biol., 200:495.
Honig, C.R. 1988. Modern Cardiovascular Physiology. 2nd Ed, Little Brown, Boston.
Honig, C.R., and Gayeski, T.E.J., 1989, Precapillary O2 loss and arteriovenous O2 diffusion shunt are below limit of detection in myocardium, Adv. Exper. Med. Biol., 247:591
Honig, C.R., Gayeski, T.E.J., and Frierson, J.F., 1989, Anatomic determinant of O2 flux density at cardiac capillaries, Am. J. Physiol., 256:H375.
Katz, S.A., and Feigl, E.O., 1988, Systole has little effect on diastolic coronary artery blood flow, Circ. Res., 62:443
Kreuzer, F., and Hoofd, 1987, Facilitated diffusion of oxygen and carbon dioxide, in: “Handbook of Physiology, Section 3: The Respiratory System. Volume IV: Gas Exchange. L.E. Farhi, and S.M. Tenney, eds., Am. Physiol. Soc., Bethesda, Maryland.
Omens, J.H., 1988, Left ventricular strain in the no-load state due to the existence of residual stress. (Thesis). University of California, San Diego, LaJolla.
Vetterlein, F., and Schmidt, C, 1985, Dilatory capacity of the coronary system in the anesthetized rat, Basic Res. Cardiol., 80:661.
Waldman, L.K., Fung, Y.C., and Covell, J.W., 1985, Transmural myocardial deformation in the canine left ventricle. Normal in vivo three-dimensional finite strains. Circ. Res., 57:152.
Weiss, H.R., Neubauer, J.A., Lipp, J.A., and Sinha, A.K., 1978, Quantitative determination of regional oxygen consumption in the dog heart, Circ. Res., 42:394.
Wittenberg, B.A., and Wittenberg, J.B., 1989, Transport of oxygen in muscle, Ann. Rev. Physiol., 51:857.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Honig, C.R., Gayeski, T.E.J. (1990). Effect of Tachycardia on Intracellular PO2 and Reserves of O2 Transport in Subendocardium of Mouse Left Ventricle. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_45
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8181-5_45
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8183-9
Online ISBN: 978-1-4684-8181-5
eBook Packages: Springer Book Archive