Effect of Tachycardia on Intracellular PO2 and Reserves of O2 Transport in Subendocardium of Mouse Left Ventricle

  • C. R. Honig
  • T. E. J. Gayeski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


The purpose of this study is to evaluate reserves of O2 transport in myocardium using tachycardia as a stimulus. The O2 saturations of hemoglobin (Hb) in microvessels and myoglobin (Mb) in individual myocytes are the measured responses. The latter is of particular interest in that it represents the net balance of all determinants of O2 supply and demand.


Maximum Heart Rate Diffusive Transport Preparative Procedure Subendocardial Ischemia Transmural Gradient 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • C. R. Honig
    • 1
  • T. E. J. Gayeski
    • 1
  1. 1.School of Medicine and DentistryThe University of RochesterRochesterUSA

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