Brain Ischemic Depolarization and Vasospasm in the Mongolian Gerbil: The Dependence on Energy Depletion Levels
The understanding of the various pathological events occuring in the ischemic brain of an animal model has significant implications to the treatment of patients undergoing stroke. One of the events that occurs under ischemia is the ischemic depolarization (ID) during which various pathological changes take place in the brain (Harris et al 1981, Hansen 1985, Siesjo and Bengtson 1989). The mechanism behind the development of ID is not clear as yet, although ion homeostasis disturbances are involved (Mori et al 1987). The inhibition of the Na+-K+-ATPase is energy depletion dependent, and an immediate response of the brain to ischemia (Erecinska & Silver 1989) will result in extracellular K+ accumulation. In the Mongolian gerbil (Meriones Unguiculatus), unilateral carotid artery occlusion creates a variable level of ischemia in the ipsilateral hemisphere (in different animals) while the contralateral side is not affected significantly (Levine and Payan 1966, Levy and Brierly 1974, Mayevsky 1978, Mayevsky and Breuer 1989).
KeywordsMongolian Gerbil Carotid Artery Occlusion NADH Level Gerbil Brain Fiber Optic Bundle
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