Oxygen Supply and Brain Function in Vivo: A Multiparametric Monitoring Approach in the Mongolian Gerbil

  • A. Mayevsky
  • K. H. Frank
  • S. Nioka
  • M. Kessler
  • B. Chance
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


The on-line evaluation of brain physiological and biochemical functions in vivo is expected to contribute to a better understanding of the development of a pathophysiological state. The development and usage of a multiprobe assembly (MPA) for the monitoring of the metabolic, ionic and electrical activities from the cerebral cortex of experimental animals was the subject of our previous publications (Friedli et al 1982, Mayevsky et al 1980, 1985, Mayevsky and Zarchin 1987). In the present study we further extended the MPA to include a second fiber optic bundle for the monitoring of intracapillary hemoglobin oxygenation (oxy-deoxy Hb) using the EMPHO I device (Frank et al 1984a,b, 1989).


Light Guide Cortical Spreading Depression Spreading Depression Mongolian Gerbil Carotid Artery Occlusion 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • A. Mayevsky
    • 1
  • K. H. Frank
    • 2
  • S. Nioka
    • 1
  • M. Kessler
    • 2
  • B. Chance
    • 1
  1. 1.Dept. of Biochemistry and BiophysicsMedical School University of PennsylvaniaPhiladelphiaUSA
  2. 2.Institut für Physiologie und KardiologieUniversität Erlangen-NürnbergErlangenWest Germany

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