The Cardiovascular Effects of the Surfactant Pluronic F68 in Anesthetized Dogs

  • Anne-Marie Gosselin
  • G. P. Biro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


Perfluorocarbons (PFC’s) have a high solubility for oxygen and carbon dioxide. This property suggests their potential usefulness as oxygen transporting ‘blood substitutes’. Unfortunately, PFC’s are neither miscible, nor soluble in water and therefore, they must be prepared as emulsions for use as ‘blood substitutes’ (Biro and Blais, 1987). The preparation most extensively investigated is Fluosol-DAR. When it was administered to animals or humans, a variety of “beneficial” actions have been reported, including successful resuscitation from hemorrhagic shock, salvage of ischemic organs and a general improvement in oxygen supply to the tissues (Biro, 1985; Biro and Blais, 1987). In many cases, most, if not all, “beneficial” effects have been attributed to the PFC component and the extra oxygen carried in solution in this phase.


Myocardial Blood Flow Hemorrhagic Shock Filling Pressure Blood Substitute Amniotic Fluid Embolism 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Anne-Marie Gosselin
    • 1
  • G. P. Biro
    • 1
  1. 1.Department of Physiology, Faculty of MedicineUniversity of OttawaOttawaCanada

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