Oxygen-Transport Fluids Based on Perfluorochemicals: Effects on Liver Biochemistry

  • Kenneth C. Lowe
  • Fiona H. Armstrong
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


Emulsified perfluorochemicals (PFCs) have been tested as oxygen transport fluids in several species, including man (Lowe, 1987, 1988a,b). The most widely used preparation is the “first-generation” commercial emulsion, Fluosol-DA 20% (F-DA) which contains perfluorodecalin (FDC) and perfluorotripropylamine (FTPA) emulsified with the poloxamer surfactant, Pluronic F-68 (Naito and Yokoyama, 1978). An additional commercial formulation, Oxypherol (FC-43), which consists of emulsified perfluorotributylamine (FTBA), is also available for animal experiments (Lowe and Bollands, 1985).


Liver Weight Microsomal Cytochrome Blood Substitute Perfluorocarbon Emulsion Commercial Emulsion 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kenneth C. Lowe
    • 1
  • Fiona H. Armstrong
    • 1
  1. 1.Mammalian Physiology Unit, Department of ZoologyUniversity of NottinghamNottinghamUK

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