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Stroma-Free Hemoglobin Solutions Prepared by Crystallization and Ultrafiltration Methods; Comparison of Composition and Coronary Vasoconstrictor Potency

  • Mia E. Lang
  • B. Korecky
  • P. J. Anderson
  • G. P. Biro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

Stromafree hemoglobin solution (SFHS), obtained by osmotic lysis of human erythrocytes, has been proposed as a ‘blood substitute’ (Rabiner, 1975). Its long-term usefulness is limited by the high oxygen affinity and short intravascular retention of the native hemoglobin (Kaplan and Murthy, 1975; Moss et al., 1976; DeVenuto et al., 1977). A further limiting factor was found to be the coronary vasoconstrictor activity found to be present in various SFHS preparations, even after substantial dilution (Vogel et al., 1986; Biro et al., 1988). This vasoconstrictor activity should have been anticipated from the findings in the neurosurgical literature (Toda et al., 1980; Okwuasaba, et al., 1981; Boullin et al., 1983), showing that hemolysate is a powerful constrictor of cerebral blood vessels.

Keywords

Coronary Perfusion Pressure Left Ventricular Systolic Pressure Hemoglobin Solution Coronary Vasoconstrictor High Oxygen Affinity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Mia E. Lang
    • 1
  • B. Korecky
    • 1
  • P. J. Anderson
    • 1
  • G. P. Biro
    • 1
  1. 1.Department of Physiology, Faculty of MedicineUniversity of OttawaOttawaCanada

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