Advertisement

Effects of SO2 and pH on Blood-Gas Partition Coefficients of Inert Gases

  • Kazuhiro Yamaguchi
  • Masaaki Mori
  • Akira Kawai
  • Kohichiro Asano
  • Tomoaki Takasugi
  • Akira Umeda
  • Tetsuro Yokoyama
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)

Abstract

A potential effect of saturation of hemoglobin with O2 (SO2) as well as of pH in the blood on blood-gas partition coefficients (λ = blood/gas concentration ratio in equilibrium) for certain inert gases has been postulated by several authors (Steen, 1963; Robertson et al., 1986). Since such variation in X might affect inert gas exchange in the lung, the present study systematically reinvestigated SO2 and pH dependence of λ using human blood.

Keywords

Interstitial Lung Disease Mixed Venous Blood Lung Unit Pulmonary Capillary Blood Isotonic Buffer Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Evans, J.W., and Wagner, P.D., 1977, Limits on V̇A/Q̇ distributions from analysis of experimental inert gas elimination, J. Appl. Physiol., 42:889.PubMedGoogle Scholar
  2. Farhi, L.E., 1967, Elimination of inert gas by the lung, Respir. Physiol., 3:11.Google Scholar
  3. Kelman, G.R. 1967, Digital computer procedure for the conversion of PCO2 into blood CO2 content, Respir. Physiol., 3:111.CrossRefGoogle Scholar
  4. Robertson, H.T., Whitehead, J., and Hlastala, M.P., 1986, Diffusion-related differences in elimination of inert gases from the lungs, J. Appl. Physiol., 61:1162.PubMedGoogle Scholar
  5. Severinghaus, J.W., 1979, Simple, accurate equations for human blood O2 dissociation computations, J. Appl. Physiol., 46:599.PubMedGoogle Scholar
  6. Steen, J.B., 1963, The physiology of the swimbladder of the eel Anguilla Vulgaris. I. The solubility of gases and the buffer capacity of the blood, Acta Physiol. Scand. 58:124.PubMedCrossRefGoogle Scholar
  7. von Mengden, H.J., Schultehinrichs, D., and Thews, G., 1969, Dependence of plasma pH on oxygen saturation, Respir. Physiol. 6:151.CrossRefGoogle Scholar
  8. Wagner, P.D., Saltzman, H.A., and West, J.B., 1974, Measurement of continuous distributions of ventilation-perfusion ratios: theory, J. Appl. Physiol. 36:585.Google Scholar
  9. Yamaguchi, K., Mori, M., Kawai, A., and Yokoyama, T., 1988, Influences of carbon monoxide on the binding of oxygen, carbon dioxide, proton and 2,3-diphosphoglycerate to human hemoglobin, Adv. Exp. Med. Biol. 222:299.PubMedCrossRefGoogle Scholar
  10. Yokoyama, T., and Farhi, L.E., 1967, The study of ventilation-perfusion ratio distribution in the anesthetized dog by multiple inert gas washout, Respir. Physiol., 3:166.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kazuhiro Yamaguchi
    • 1
  • Masaaki Mori
    • 1
  • Akira Kawai
    • 1
  • Kohichiro Asano
    • 1
  • Tomoaki Takasugi
    • 1
  • Akira Umeda
    • 1
  • Tetsuro Yokoyama
    • 1
  1. 1.Department of Medicine, School of MedicineKeio UniversityTokyo, 160Japan

Personalised recommendations