Carbon Monoxide Equilibrium Curve of Human Umbilical Cord Blood
The presence of carbon monoxide (CO) in blood may be an important factor impairing tissue oxygenation because a) it decreases the concentration of functional hemoglobin and b) it increases the O2 affinity of the functional hemoglobin, both effects depending critically upon the amount of CO bound to hemoglobin (HbCO) and consequently upon the CO partial pressure (PCO) at which blood has been equilibrated. Because CO is suspected to have deleterious effects on fetal growth (Longo, 1987), we have investigated the CO affinity of the fetal blood by determining the CO dissociation curve of umbilical cord blood with the aim of comparing its position and shape with that of maternal blood. Our interest was prompted by the problem of the foeto-maternal CO equilibration.
KeywordsUmbilical Cord Blood Maternal Blood Fetal Blood Equilibrium Curve Human Umbilical Cord Blood
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