Interaction Between Organic Phosphates and Sheep Hemoglobins
It has been widely accepted that 2,3-diphosphoglycerate, which lowers the oxygen affinity (raises P50) of most mammalian blood, has little, if any, effect on sheep hemoglobins. Its small effect in sheep, relative to the effect in most mammals, was reported by Bunn (1971) who worked with dilute Hb solutions. Also, using Hb solution where the Hb was about 1/30 of the concentration found in red cells, Perutz and Imai (1980) showed that bovine Hb has little interaction with 2,3-DPG when compared with human Hb. Both sheep and cattle are Bovidae. This group, which also includes the goat, all have low affinity haemoglobins (relatively high P50in the absence of organic phosphates) and very low or zero 2,3-DPG levels in adult red cells.
KeywordsPhytic Acid Oxygen Affinity Organic Phosphate Donnan Ratio Tammar Wallaby
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