Oxygenation of Tumors Derived from ras Transformed Cells
Malignant transformation involves the activation of growth-promoting and/or the loss of growth suppressing genes. Activated ras genes are frequently found in malignant tumors (Barbacid, 1987). Considering tumor treatment, malignant transformation by ras genes has been reported to increase the cellular resistance to ionizing radiation and chemotherapy (Sklar, 1988 a,b). Besides these genetic factors, epigenetic influences such as the tumor oxygenation can modulate the effectiveness of non-surgical treatment modalities (Teicher et al., 1981; Sutherland, 1988). Since there are only insufficient data on possible interrelationships between ras activation and changes of the tumor micromilieu the tissue oxygenation of tumors derived from ras transformed fibroblast-like cells was investigated.
KeywordsVolume Doubling Time Tissue Oxygen Level SacI Fragment Intensifier Screen Harvey Murine Sarcoma Virus
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