Blood Flow, Oxygen Consumption and Tissue Oxygenation of Human Tumors

  • P. Vaupel
  • F. Kallinowski
  • P. Okunieff
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 277)


A great number of malignancies are relatively resistant to radiotherapy, chemotherapy and other non-surgical treatment modalities. A variety of factors are involved in the lack of responsiveness of these neoplasms including an intrinsic, genetically determined resistance and physiological, extrinsic (epigenetic, environmental) factors primarily created by inadequate and heterogeneous vascular networks1–3. Thus, properties such as tumor blood flow and tissue oxygen supply, factors which usually go hand in hand, can markedly influence the therapeutic response. Data on these parameters are mostly derived from rodent tumors. However, fast-growing rodent tumors might not adequately represent the multitude of neoplastic growths encountered in patients. Unfortunately, data on human tumors in situ are scarce and there may be significant errors associated with the techniques used for measurements. This should be kept in mind when comparing available results from the literature.


Oxygen Consumption Rate Strenuous Exercise Tumor Blood Flow Oxyhemoglobin Saturation Normal Oral Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    P. Vaupel and W. Miiller-Klieser, Interstitieller Raum und Mikro-milieu in malignen Tumoren. Progr. Appl. Microcirc. 2:78 (1983).Google Scholar
  2. 2.
    P. Vaupel and F. Kallinowski, Microcirculation and metabolic micro-milieu in malignant tumors. Funktionsanalyse biolos. Systeme 18: 265 (1988).Google Scholar
  3. 3.
    R. M. Sutherland, Cell and environment interactions in tumor micro-regions. The multiceli spheroid model. Science 240:177 (1988).PubMedCrossRefGoogle Scholar
  4. 4.
    R. K. Jain and K. Ward-Hartley, Tumor blood flow — Characterization, modifications, and role in hyperthermia. IEEE Trans. Sonics Ultrasonics SU-31:5Q4 (1984).Google Scholar
  5. 5.
    P. Vaupel, Pathophysiologie der Durchblutung maligner Tumoren. Funktionsanalyse biolog. Systeme 8:155 (1982).Google Scholar
  6. 6.
    M. Mäntylä, J. Heikkonen, and J. Perkkiö, Regional blood flow in human tumours measured with argon, krypton and xenon. Brit. J. Radiol. 61:379 (1988).PubMedCrossRefGoogle Scholar
  7. 7.
    II. S. Reinhold, Physiological effects of hyperthermia. Rec. Res. Cancer Res. 107:32 (1988).CrossRefGoogle Scholar
  8. 8.
    P. Vaupel, F. Kallinowski, and P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors. A review. Cancer Res, (in press).Google Scholar
  9. 9.
    P. Vaupel, F. Kallinowski, and P. Okunieff, Blood flow, metabolic micromilieu and bioenergetics of human tumors: Critical parameters in hyperthermic treatment. Progr. Hyperthermia 1 (in press).Google Scholar
  10. 10.
    O. Warburg, On respiratory impairment in cancer cells. Science 124: 269 (1956).PubMedGoogle Scholar
  11. 11.
    P. Wendling, R. Manz, G. Thews, and P. Vaupel, Inhomogeneous oxygenation of rectal carcinomas in humans. A critical parameter for preoperative irradiation? Adv. Exp. Med. Biol. 180: 293 (1984).PubMedGoogle Scholar
  12. 12.
    P. Vaupel and F. Kallinowski, Tissue oxygenation of primary and xenotransplanted human tumours. In: “Radiation Research”, E.M. Fiel-den, J.F. Fowler, J.H. Hendry, and D. Scott (eds.), London, New York, Philadelphia, Taylor & Francis (1987).Google Scholar
  13. 13.
    W. Mueller-Klieser, P. Vaupel, R. Manz, and R. Schmidseder, Intra-capillary oxyhemoglobin saturation of malignant tumors in humans. Int. J. Radiat. Oncol. Biol. Phys. 7:1397 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • P. Vaupel
    • 1
  • F. Kallinowski
    • 1
  • P. Okunieff
    • 1
  1. 1.Dept. Radiation Medicine, Harvard Medical SchoolMassachusetts General Hospital Cancer CenterBostonUSA

Personalised recommendations