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Diversity of Molecular Recognition: The Combining Sites of Monoclonal Anti Spin Label Antibodies

  • Harden M. McConnell
  • Tom Frey
  • Jacob Anglister
  • Mei Whittaker
Part of the NATO ASI Series book series (NSSA, volume 107)

Abstract

Physical chemistry includes the study of how atoms come together to form molecules, and how combinations of molecules can interact with one another to form aggregates, crystals, and macromolecules. One of the most challenging problems in the area of macromolecules is the problem of protein structure, the problem of finding the “code” that specifies how a given amino acid sequence gives rise to a three-dimensional protein structure, such as an enzyme, with a highly specific biochemical function. This problem has been already attacked with considerable success using NMR methods, through studies of the folding-unfolding of polypeptides and proteins.1 Another important facet of the problem of protein structure, and the evolution of protein structures, concerns the manner in which amino acid sequences corresponding to exons, are assembled as structural units (“modules”) to form three-dimensional structures with specific functions.2

Keywords

Light Chain Difference Spectrum Spin Label Antibody Molecule Germ Line Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Harden M. McConnell
    • 1
  • Tom Frey
    • 1
  • Jacob Anglister
    • 1
  • Mei Whittaker
    • 1
  1. 1.Stauffer Laboratory for Physical ChemistryStanford UniversityStanfordUSA

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