High Field NMR Imaging and Spectroscopy
The xumbination. of proton (1H) NNR imaging and phosphorus (31P), carbon (C) and H NNR chemical shift spectroscopy techniques for clinical applications has been a major goal of our research program. It is hoped that such a combination could provide a comprehensive dossier of the bodies’ anatomical and biochemical function to serve in the monitoring of disease states and their response to therapy and recovery. It was our perception that the major problems involved in combining the two technologies were initially instrumental and not due to any insurmountable physical obstacles. Thus the stringent requirements of chemical shift spectroscopy in the body necessitated the introduction of highly homogeneous, high field, large bore superconducting magnets. The relatively high NNR frequencies demanded of the NNR coils used in these magnet systems necessitated the development of new RF coil designs for 1H NNR imaging. The application of strong gradient magnetic fields to achieve spatial localization in NNR imaging is usually incompatible with the high magnetic field homogeneity required for resolution of chemical shift information. Hence new techniques for obtaining spatially localized spectra were required.
KeywordsPower Deposition Bowman Gray School Picture Point Strong Gradient Magnetic Field Heart Liver Kidney
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