Proton-NMR of Nuclei, Cell and Intact Tissue in Normal and Abnormal States: Significance of Relaxation Times as Correlated with Other Non-Invasive Biophysical Probes

  • C. Nicolini
  • A. Martelli
  • L. Robbiano
  • C. Casieri
  • C. Nuccetelli
  • F. De Luca
  • B. C. De Simone
  • B. Maraviglia
Part of the NATO ASI Series book series (NSSA, volume 107)


In vivo Proton NMR imaging is becoming an increasingly popular tool in diagnostic medicine for its non-invasive nature and for its high resolution (1,2). In most clinical applications the 3-D reconstructed human images are based on local measurements of T1 and T2 proton relaxation times. Increases in these relaxation times in tumors (3) have been attributed to a change in the water concentration at the cytoplasmic and/or extracellular level (4) or to a change in the physical state of water (3,5). Similarly, during the cell cycle the variations in T1, i.e., its shortening during the Gl-S transcription (6), have been correlated with cellular changes in water concentration (7). More importantly, it has been found (7) that prior to mitosis an increase in relaxation times of water protons preceeds by 4 hours the increase in water concentration, suggesting that a change in the physical state of water may preceed cell division.


Relaxation Time Partial Hepatectomy Free Induction Decay Intact Tissue Volumetric Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • C. Nicolini
    • 1
  • A. Martelli
    • 2
  • L. Robbiano
    • 2
  • C. Casieri
    • 3
  • C. Nuccetelli
    • 3
  • F. De Luca
    • 3
  • B. C. De Simone
    • 3
  • B. Maraviglia
    • 3
  1. 1.University of Genova School of MedicineItaly
  2. 2.Institute of PharmacologyUniversity of Genova School of MedicineItaly
  3. 3.Departimento di FisicaUniversitá di Roma “La Sapienza”RomaItaly

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