Allotypes of Light Chains of Rat Immunoglobulins and Their Application to the Study of Antibody Biosynthesis

  • Roald Nezlin
  • Oscar Rokhlin

Abstract

The study of allotypes of immunoglobulin (Ig) polypeptide chains has thrown considerable light on the structure of antibodies, their biosynthesis, and their genetics. The best-known genetic markers are allotypic determinants of H and L peptide chains from human and rabbit Ig. However, studying genetic regulation of Ig biosynthesis in these species is difficult. Among experimental animals, the most available and genetically thoroughly investigated is the mouse, but Ig genetic markers have been reported only for H chains. The genetics of several dozen highly inbred strains of rats have also been well studied, particularly their Ig, since the recent discovery of their Ig-producing myeloma tumors (Bazin et al., 1973).

Keywords

Cellulose fIltration Urea Bromide Fractionation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Armerding, D., 1971, Eur. J. Immunol. 1:39.PubMedCrossRefGoogle Scholar
  2. Atassi, M.S., 1975, Immunochemistry 5:423.CrossRefGoogle Scholar
  3. Bazin, H., Beckers, A., Deckers, C, and Moriamé, M., 1973, J. Natl. Cancer Inst. 51:1359.PubMedGoogle Scholar
  4. Bazin, H., Beckers, A., Vaerman, J.-P., and Heremans, J. F., 1974, J. Immunol. 112:1035.PubMedGoogle Scholar
  5. Beckers, A., and Bazin, H., 1975, Immunochemistry 12:671.PubMedCrossRefGoogle Scholar
  6. Beckers, A., Querinjean, H., and Bazin, H., 1974, Immunochemistry 11:605.PubMedCrossRefGoogle Scholar
  7. Björk, J., Karlsson, F.A., and Bergågard, I., 1971, Proc. Natl Acad. Set USA 68:1707.CrossRefGoogle Scholar
  8. Binz, H., and Lindenmann, J., 1974, Cell. Immunol. 10:260.PubMedCrossRefGoogle Scholar
  9. Catty, D., Humphrey, J.H., and Gell, P.G.H., 1969, Immunology 16:409.PubMedGoogle Scholar
  10. Cooper, A.G., and Steinberg, A.C., 1970, J.Immunol. 104:1108.PubMedGoogle Scholar
  11. Dray, S., and Nisonoff, A., 1965, Molecular and Cellular Basis of Antibody Formation, p. 175, Academia, Praha.Google Scholar
  12. Eichmann, K., 1972, Eur. J. Immunol. 2:301.PubMedCrossRefGoogle Scholar
  13. Eichmann, K., Tung, A.S., and Nisonoff, A., 1974, Nature (London) 250:509.CrossRefGoogle Scholar
  14. Gutman, G.A., and Weissman, I.L., 1971, J. Immunol. 107:1390.PubMedGoogle Scholar
  15. Gutman, G.A., Loh, E., and Hood, L., 1975,Proc. Natl. Acad. Sci. USA 72:5046.PubMedCrossRefGoogle Scholar
  16. Haimovich, J., Jaton, J.-C, and Pink, J.R.L., 1974, Eur. J. Immunol. 4:290.PubMedCrossRefGoogle Scholar
  17. Karlsson, F.A., Peterson, P.A., and Berggård, I., 1969, Proc. Natl. Acad. Sci. USA 64:1257.PubMedCrossRefGoogle Scholar
  18. Kim, Y.D., and Karush, F., 1974, Immunochemistry 11:147.PubMedCrossRefGoogle Scholar
  19. Kindt, T.J., Mandy, W.J., and Todd, C.W., 1970, Biochemistry 9:2028.PubMedCrossRefGoogle Scholar
  20. Kitagawa, M., Yagi, Y., and Pressman, D., 1965, J.Immunol. 95:446.PubMedGoogle Scholar
  21. Mage, R.G., 1974, Curr. Topics Microbiol. Immunol. 63:131.Google Scholar
  22. Mage, R., Lieberman, R., Potter, M., and Terry, W.D., 1973, The Antigens(M. Sela, ed), p. 300, Academic Press, New York.Google Scholar
  23. Mäkelä, O., 1970, Transplant. Rev. 5:3.PubMedGoogle Scholar
  24. Mäkelä, O., Ruoslanti, E., and Seppälä, I.J.T., 1970, Immunochemistry 7:917.PubMedCrossRefGoogle Scholar
  25. McMichael, A.J., Phillips, J.M., Williamson, A.R., Imanishi, T., and Mäkelä, O., 1975, Immunogenetics 2:161.CrossRefGoogle Scholar
  26. Milstein, C.P., Steinberg, A.G., McLaughlin, C.L., and Solomon, A., 1974, Nature (London) 248:160.CrossRefGoogle Scholar
  27. Nezlin, R.S., 1964, Biokhimia 29:548.Google Scholar
  28. Nezlin, R. S., 1976, Structure and Biosynthesis of Antibodies, Plenum Press, New York.Google Scholar
  29. Nezlin, R.S., and Kulpina, L.M., 1967, Immunochemistry 4:269.PubMedCrossRefGoogle Scholar
  30. Nezlin, R.S., and Rokhlin, O.V., 1969, FEBS Symposium, Vol. 15 (F. Franek and D. Shugar, eds.), p. 117, Academic Press, New York.Google Scholar
  31. Nezlin, R.S., Rokhlin, O.V., and Vengerova, T.I., 1974a, Ann. Immunol. (Inst. Pasteur) 125c:93.Google Scholar
  32. Nezlin, R.S., Vengerova, T.I., Rokhlin, O.V., and Machulla, H.K.G., 1974b, Immunochemistry 11:517.PubMedCrossRefGoogle Scholar
  33. Nezlin, R.S., Vengerova, T.I., Rokhlin, O.V., and Machulla, H.K.G., 1975, Antibody Structure and Molecular Immunology, FEBS Symposium, Vol. 36 (J. Gergely and G.A. Medgyesi, eds.), p. 93, Akademiai Kiado, Budapest.Google Scholar
  34. Pink, R., Wang, A.-C, and Fudenberg, H.H., 1971, Annu. Rev. Med. 22:145.PubMedCrossRefGoogle Scholar
  35. Poljak, K.J., Amzel, L.M., Chen, B.L., Phjzackerley, R.P., and Saul F., 1974, Proc. Natl. Acad. Sci USA.71:3440.PubMedCrossRefGoogle Scholar
  36. Polmar, S.H., and Steinberg, A.G., 1967, Biochem. Genet. 1:117.PubMedCrossRefGoogle Scholar
  37. Potter, M., and Lieberman, R., 1970, J. Exp. Med. 132:737.PubMedCrossRefGoogle Scholar
  38. Reisfeld, R.A., and Inman, J.L., 1968, Immunochemistry 5:503.CrossRefGoogle Scholar
  39. Rokhlin, O.V., 1976,Mol. Biol. USSR 10:206.Google Scholar
  40. Rokhlin, O.V., and Nezlin, R.S., 1969, Probl. Med. Chem. USSR 15:439.Google Scholar
  41. Rokhlin, O.V., and Nezlin, R.S., 1973, Eur. J. Immunol. 3:732.PubMedCrossRefGoogle Scholar
  42. Rokhlin, O.V., and Nezlin, R.S., 1974, Scand. J. Immunol. 3:209.PubMedCrossRefGoogle Scholar
  43. Rokhlin, O.V., Vengerova, T.I., and Nezlin, R.S., 1970, Mol. Biol. USSR 4:906.Google Scholar
  44. Rokhlin, O.V., Vengerova, T.I., and Nezlin, R.S., 1971, Immunochemistry 8:525.PubMedCrossRefGoogle Scholar
  45. Rokhlin, O.V., Vengerova, T.I., and Nezlin, R.S., 1972, Mol. Biol USSR 6:263.Google Scholar
  46. Rokhlin, O.V., Nezlin, R.S., and Machulla, H.K.G., 1975, Immunochemistry 12:311.PubMedCrossRefGoogle Scholar
  47. Schiffer, M., Girling, R.L., Ely, K.R., and Edmundson, A.B., 1973, Biochemistry12:4620.PubMedCrossRefGoogle Scholar
  48. Sela, M., 1969, Science 166:1365.PubMedCrossRefGoogle Scholar
  49. Solomon, A., and McLaughlin C.L., 1969, J. Biol. Chem. 12:3393.Google Scholar
  50. Starace, V., and Querinjean, P., 1975, J. Immunol. 115:59.PubMedGoogle Scholar
  51. Vengerova, T.I., Rokhlin, O.V., and Nezlin, R.S., 1972a, Immunochemistry 9:413.CrossRefGoogle Scholar
  52. Vengerova, T.I., Rokhlin, O.V., and Nezlin, P.S., 1972b, Immunochemistry 9:1239.CrossRefGoogle Scholar
  53. Waterfield, M.D., Morris, J.E., Hood, L., and Todd, C.W., 1973, J. Immunol 110:227.PubMedGoogle Scholar
  54. Wigzell, H., 1973, Scand. J. Immunol 2:199.PubMedCrossRefGoogle Scholar
  55. Williamson, A.R., Premkumar, E., and Shoyab, M., 1975, Fed. Proc. 34:28.PubMedGoogle Scholar
  56. Wistar, R., 1969, Immunology 17:23.PubMedGoogle Scholar
  57. Zappacosta, S., and Rossi, G., 1972, Immunochemistry 9:689.PubMedCrossRefGoogle Scholar
  58. Zeeuws, R., and Strosberg, A.D., 1975, Arch. Intern. Physiol Biochem. 83:41.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • Roald Nezlin
    • 1
  • Oscar Rokhlin
    • 1
  1. 1.Institute of Molecular BiologyUSSR Academy of SciencesMoscowUSSR

Personalised recommendations