Abstract
Surface immunoglobulins of lymphocytes probably function in the recognition of antigens by these cells. Considerable evidence suggests that surface immunoglobulin molecules contain the same set of V-region combining sites for antigen as do circulating antibodies to that antigen (Binz and Wigzell, 1975; Cosenza and Köhler, 1972; Eichmann and Rajewsky, 1975; McKearn, 1974; McKearn et al., 1974) but that the constant region of the receptor immunoglobulin heavy chain might differ from the constant region of circulating antibody in its capacity to become associated with the plasma membrane and to function in the initiation of lymphocyte differentiation. Therefore, knowledge of the structure of lymphocyte surface immunoglobulin is crucial to an understanding of the molecular mechanisms of antigen-specific lymphocyte activation.
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Marchalonis, J.J. (1976). Surface Immunoglobulins of B and T Lymphocytes: Molecular Properties, Association with the Cell Membrane, and a Unified Model of Antigen Recognition. In: Eisen, H.N., Reisfeld, R.A. (eds) Contemporary Topics in Molecular Immunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8142-6_5
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