The Dietary Causes of Degenerative Diseases

Nutrients vs Foods
  • T. Colin Campbell


For a very long time, food has been recognized as being important in the development of disease, at least back to the time of Hippocrates 2500 years ago when he said, “Whoever gives these things (food) no consideration, and is ignorant of them, how can he understand the diseases of man?” Much later, in 1849, John Hughes Bennett, Senior Professor of Clinical Medicine, whose textbook on medicine appears to have been the standard of its day in Britain, pursued the idea that dietary fat was important in the causation of cancer when he first stated that, “The circumstances which diminish obesity, and a tendency to the formation of fat, would seem a priori to be opposed to the cancerous tendency” (p. 250) (1), then later, in 1865, urged that, “In carcinoma... a diminution of this element (fat) in the food should be aimed at” (2). In more modern times, the studies of Tannenbaum and his colleagues (2–4) during the 1940s and 1950s on the role of nutrition in the development of tumors in experimental animals and the research of Ancel Keys and colleagues on diet and cardiovascular disease (5,6) often have been assigned landmark status.


Breast Cancer Breast Cancer Risk Degenerative Disease Plant Origin Animal Protein 
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  1. 1.
    Bennett JH. On Cancerous and Cancroid Growths. Edinburgh: Sutherland and Knox, 1849.Google Scholar
  2. 2.
    Bennett JH. Clinical Lectures on the Principals and Practice of Medicine. Fourth Edition. Edinburgh: Adam and Charles Black, 1865.Google Scholar
  3. 3.
    Tannenbaum A. The genesis and growth of tumors II. Effects of caloric restriction perse.CancerRes 1942; (2):460–467.Google Scholar
  4. 4.
    Tannenbaum A, Silverstone H. Nutrition and the genesis of tumours. Cancer 1957; 1:306–334.Google Scholar
  5. 5.
    Keys A, Anderson JT, Grande F. Serum-cholesterol response to dietary fat. Lancet 1957; 272:787.CrossRefGoogle Scholar
  6. 6.
    Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in diet. Metabolism 1965; 14:747–787.CrossRefGoogle Scholar
  7. 7.
    United States Department of Health and Human Services. The Surgeon General’s Report on Nutrition and Health. Washington, DC: Superintendent of Documents, US Government Printing Office, 1988.Google Scholar
  8. 8.
    Trowell HC, Burkitt DP. Western Diseases: Their Emergence and Prevention. London: EdwardArnold, 1981.Google Scholar
  9. 9.
    Dumont R. Mes Combats. Paris: Plon Publishers, 1989.Google Scholar
  10. 10.
    Walshe WH. The Nature and Treatment of Cancer. London: Taylor and Walton, 1846.Google Scholar
  11. 11.
    Waterlow JC. Metabolic adaptation to low intakes of energy and protein. Ann Rev Nutr 1986; 6:495–526.CrossRefGoogle Scholar
  12. 12.
    American Heart Association. Committee report, rationale for the diet-heart statement of the American Heart Association. Circulation 1982; 65:839A-854A.CrossRefGoogle Scholar
  13. 13.
    Committee on Diet Nutrition and Cancer. Diet, Nutrition and Cancer. Washington, DC: National Academy Press, 1982.Google Scholar
  14. 14.
    National Research Council, Committee on Diet and Health. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Press, 1989.Google Scholar
  15. 15.
    O’Connor TP, Campbell TC. Dietary guidelines. In: Ip C, Birt D, Mettlin C, Rogers A, eds. Dietary Fat and Cancer. New York: Liss, 1986; 731–771.Google Scholar
  16. 16.
    Keys A. Coronary heart disease in seven countries. Circulation 1979; 41(Suppl. 1):1–19.Google Scholar
  17. 17.
    Drasar BS, Irving D. Environmental factors and cancer of the colon and breast. Br J Cancer 1973; 27:167–172.CrossRefGoogle Scholar
  18. 18.
    Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 1975; 15:617–631.CrossRefGoogle Scholar
  19. 19.
    Carroll KK. Experimental evidence of dietary factors and hormone-dependent cancers. CancerRes 1975; 35:3374–3383.Google Scholar
  20. 20.
    Keys A. Seven countries. A Multivariate Analysis of Death and Coronary Heart Disease. Cambridge, MA: Harvard University Press, 1980.Google Scholar
  21. 21.
    Rous P. The influence of diet on transplanted and spontaneous mouse tumors. J Exp Med 1914; 20:433–451.CrossRefGoogle Scholar
  22. 22.
    Tannenbaum A, Silverstone H. Nutrition in relation to cancer. Adv CancerRes 1953; 1:451–501.CrossRefGoogle Scholar
  23. 23.
    Ross MH, Bras G. Tumor incidence patterns and nutrition in the rat. JNutr 1965; 87:245–260.Google Scholar
  24. 24.
    Freedman LS, Clifford C, Messina M. Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. CancerRes 1990; 50:5710–5719.Google Scholar
  25. 25.
    Rose DP. Dietary factors and breast cancer. Cancer Surveys 1986; 3:671–687.Google Scholar
  26. 26.
    Carroll KK, Braden LM, Bell JA, Kalamegham R. Fat and cancer. Cancer 1986; 58:1818–1825.CrossRefGoogle Scholar
  27. 27.
    Cohen LA. Diet and cancer. Sci Am 1987; 257:42–48.CrossRefGoogle Scholar
  28. 28.
    US Department of Agriculture ARS. Composition of Foods: Raw, Processed, Prepared. American Handbook No. 8, 1968, Expansion (March, 1972). Washington, DC: Government Printing Office, 1978.Google Scholar
  29. 29.
    Greenwald P. Manipulation of nutrients to prevent cancer. Hosp Pract 1984; 19:119–134.Google Scholar
  30. 30.
    Allen RE. The Concise Oxford Dictionary of Current English. Oxford, UK: Clarendon Press, 1990.Google Scholar
  31. 31.
    LaChance P. Dietary intake of carotenes and the carotene gap. Clin Nutr 1988; 7:118–122.Google Scholar
  32. 32.
    Malone WF, Kelloff GJ, Boone C, Nixon DW. Chemoprevention and modern cancer prevention. Prev Med 1989; 18:553–561.CrossRefGoogle Scholar
  33. 33.
    Boone CW, Kelloff GJ, Malone WE. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review. Cancer Res 1990; 50:2–9.Google Scholar
  34. 34.
    Block G. Vitamin C and cancer prevention: the epidemiologic evidence. Am J Clin Nutr 1991; 53:270S-282S.Google Scholar
  35. 35.
    Chisholm GM. Antioxidants and atherosclerosis: a current assessment. Clin Cardiol 1991; 14(2 Suppl. 1):25–30.CrossRefGoogle Scholar
  36. 36.
    Block G. The data support a role for antioxidants in reducing cancer risk. Nutr Revs 1992; 50:207–213.CrossRefGoogle Scholar
  37. 37.
    Prentice RL, Kakar F, Hursting S, Sheppard L, Klein R, Kushi LH. Aspects of the rationale for the Women’s Health Trial. J Natl CancerInst 1988; 80:802–814.CrossRefGoogle Scholar
  38. 38.
    Anonymous. Fred Hutchinson Center wins $140 million contract to coordinate NIH Women’s Health Initiative. Cancer Lett 1992; 18:1–2.Google Scholar
  39. 39.
    Henderson MM, Kushi LH, Thompson DJ, Gorbach SL, Clifford CK, Insull W, Jr, Moskowitz M, Thompson RS. Feasibility of a randomized trial of a low-fat diet for the prevention of breast cancer: dietary compliance in the Women’s Health Trial Vanguard Study. Prev Med 1990; 19:115–133.CrossRefGoogle Scholar
  40. 40.
    White E, Shattuck AL, Kristal AR, Urban N, Prentice RL, Henderson MM, Insull W, Jr, Moskowitz M, Goldman S, Woods MN. Maintenance of a low-fat diet: follow-up of the Women’s Health Trial. Cancer Epidemiol Biomarkers Prev 1992;1:315–323.Google Scholar
  41. 41.
    Gorbach SL, Morrill-LaBrode A, Woods MN, Dwyer JT, Seiles WD, Henderson M, Insull W, Jr, Goldman S, Thompson D, Clifford C, Sheppard L. Changes in food patterns during a low-fat dietary intervention in women. J Am DietAssoc 1990; 90:802–809.Google Scholar
  42. 42.
    Insull WI, Jr., Henderson MM, Prentice RL, Thompson DJ, Clifford C, Goldman S, Gorbach S, Moskowitz M, Thompson R, Woods M. Results of a randomized feasibility study of a low-fat diet. Arch Int Med 1990; 150:421–427.CrossRefGoogle Scholar
  43. 43.
    Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Hennekens CH, Speizer FE. Dietary fat and the risk of breast cancer. N EnglJMed 1987; 316:22–28.CrossRefGoogle Scholar
  44. 44.
    Chen J, Campbell TC, Li J, Peto R. Diet, Life-Style and Mortality in China. A Study of the Characteristics of 65 Chinese Counties. Oxford, UK; Ithaca, NY; Beijing, PRC: Oxford University Press; Cornell University Press; People’s Medical Publishing House, 1990.Google Scholar
  45. 45.
    Boyd NF, Cousins M, Beaton M, Fishell E, Wright B, Fish B, Kriukov V, Lockwood G, Tritchler D, Hanna W, Page DL. Clinical trial of low-fat, high-carbohydrate diet in subjects with mammographic dysplasia: report of early outcomes. J Natl CancerInst 1988; 80:1244–1248.CrossRefGoogle Scholar
  46. 46.
    Schectman G, McKanney WP, Pleuss J, Hoffman RG. Dietary intake of Americans reporting adherence to a low cholesterol diet (NHANES II). AmJPublic Health 1990; 80:698–703.CrossRefGoogle Scholar
  47. 47.
    Sirtori CR, Noseda G, Descovich GC. Studies on the use of a soybean protein diet for the management of human hyperlipoproteinemias. In: Gibney MJ, Kritchevsky D, eds. Animal and Vegetable Proteins in Lipid Metabolism and Atherosclerosis. New York: Liss, 1983; 135–148.Google Scholar
  48. 48.
    Carroll KK. Dietary proteins and amino acids—their effects on cholesterol metabolism. In: Gibney MJ, Kritchevsky D, eds. Animal and Vegetable Proteins in Lipid Metabolism and Atherosclerosis. New York: Liss, 1983; 9–17.Google Scholar
  49. 49.
    Gaddi A, Ciarrocchi A, Matteucci A, Rimondi S, Raviglia G, Descovich GC, Sirtori CR. Dietary treatment for familial hypercholesterolemia—differential effects of dietary soy protein according to the apolipoprotein E phenotypes. Am J Clin Nutr 1991; 53:1191–1196.Google Scholar
  50. 50.
    Hawrylewicz EJ, Huang HH, Kissane JQ, Drab EA. Enhancement of the 7,12-dimethylbenz(a)anthracene (DMBA) mammary tumorigenesis by high dietary protein in rats. Nutr Reps Int 1982; 26:793–806.Google Scholar
  51. 51.
    Appleton BS, Campbell TC. Dietary protein intervention during the post-dosing phase of aflatoxin Bl-induced hepatic preneoplastic lesion development. JNatl CancerInst 1983; 70:547–549.Google Scholar
  52. 52.
    Hawrylewicz EJ, Huang HH, Liu J. Dietary protein enhancement ofiV-nitrosomethylurea-induced mammary carcinogenesis, and their effect on hormone regulation in rats. Cancer Res 1986; 46:4395–4399.Google Scholar
  53. 53.
    Hawrylewicz EJ, Huang HH, Blair WH. Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats. J Nutr 1991; 121:1693–1698.Google Scholar
  54. 54.
    Youngman LD, Campbell TC. Inhibition of aflatoxin Bl- induced gamma-glutamyl transpeptidase positive (GGT+) hepatic preneoplastic foci and tumors by low protein diets: evidence that altered GGT+ foci indicate neoplastic potential. Carcinogenesis 1992; 13:1607–1613.CrossRefGoogle Scholar
  55. 55.
    Margen S, Chu J-Y, Kaufmann NA, Calloway DH. Studies in calcium metabolism. Am J Clin Nutr 1975; 27:584–589.Google Scholar
  56. 56.
    Kerstetter JE, Allen LH. Dietary protein increases urinary calcium. JNutr 1990; 120:134–136.Google Scholar
  57. 57.
    Abelow BJ, Holford TR, Insogna KL. Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int 1992; 50:14–18.CrossRefGoogle Scholar
  58. 58.
    Youngman LD. The Growth and Development of Aflatoxin Bl- Induced Preneoplastic Lesions, Tumors, Metastasis, and Spontaneous Tumors as They are Influenced by Dietary Protein Level, Type, and Intervention. Ithaca, NY: Cornell University, PhD Thesis, 1990.Google Scholar
  59. 59.
    Dole VP, Dahl LK, Schwartz GC, Cotzias GC, Thaysen JH, Harris C. Dietary treatment of hypertension. The effect of protein on appetite and weight. J Clin Invest 1953; 32:185–191.CrossRefGoogle Scholar
  60. 60.
    Miller DS, Payne PR. Weight maintenance and food intake. JNutr 1962; 78:255–262.Google Scholar
  61. 61.
    Rothwell NJ, Stock MJ, Tyzbir RS. Mechanisms of thermo- genesis induced by low protein diets. Metabolism 1983; 32:257–261.CrossRefGoogle Scholar
  62. 62.
    Horio F, Yoimgman LD, Bell RC, Campbell TC. Thermogenesis, low-protein diets, and decreased development of AFBl-induced preneoplastic foci in rat liver. Nutr Cancer 1991; 16:31–41.CrossRefGoogle Scholar
  63. 63.
    Huang HH, Hawrylewicz EJ, Kissane JQ, Drab EA. Effect of protein diet on release of prolactin and ovarian steroids in female rats. Nutr Rpts Int 1982; 26:807–820.Google Scholar
  64. 64.
    Pyska H, Styczynski H. Effect of various protein levels in the diet on mammary gland growth in rats. J Dairy Res 1979; 46:551–554.CrossRefGoogle Scholar
  65. 65.
    Sanz MCA, Liu J-M, Huang HH, Hawrylewicz EJ. Effect of dietary protein on morphologic development of rat mammary gland. JNatl CancerInst 1986; 77:477–487.Google Scholar
  66. 66.
    Subcommittee on Laboratory Animal Nutrition. Nutrient Requirements of Laboratory Animals. Second revised edition, number 10. Washington, DC: National Academy Press, 1972.Google Scholar
  67. 67.
    Dunaif GE, Campbell TC. Dietary protein level and aflatoxin Bl-induced preneoplastic hepatic lesions in the rat. J Nutr 1987; 117:1298–1302.Google Scholar
  68. 68.
    Meyskens FL, Coming of age—the chemoprevention of cancer. NEngl JMed 1990; 323:825–827.CrossRefGoogle Scholar
  69. 69.
    Self S, Prentice R, Iverson D, Henderson M, Thompson D, Byar D, Insull W, Gorbach S, Clifford C, Goldman S, Urban N. Statistical design of the Women’s Health Trial. Controlled Clin Trials 1988; 9:119–136.CrossRefGoogle Scholar
  70. 70.
    Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spielgelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer. JAMA 1992; 268:2037–2044.CrossRefGoogle Scholar
  71. 71.
    Jones DY, Schatzkin A, Green SB, Block G, Brinton LA, Ziegler RG, Hoover R, Taylor PR. Dietary fat and breast cancer in the National Health and Nutrition Examination Survey I Epidemiologic follow-up study. JNatl CancerInst 1987; 79:465–471.Google Scholar
  72. 72.
    Mills PK, Beeson WL, Phillips RL, Fräser GE. Dietary habits in breast cancer incidence among Seventh-Day Adventists. Cancer 1989; 64:582–590.CrossRefGoogle Scholar
  73. 73.
    Knekt P, Albanes D, Seppanen R, Aromaa A, Järvinen R, Hyvönen L, Teppo L, Pekkala E. Dietary fat and risk of breast cancer. Am J Clin Nutr 1990; 52:903–908.Google Scholar
  74. 74.
    Goodwin PJ, Boyd NF. Critical appraisal of the evidence that dietary fat intake is related to breast cancer risk in humans. JNatl CancerInst 1987; 79:473–485.Google Scholar
  75. 75.
    Willett W. Nutritional Epidemiology. New York: Oxford University Press, 1990.Google Scholar
  76. 76.
    Ames B. Dietary carcinogens and anticarcinogens. Science 1983; 221:1256–1264.CrossRefGoogle Scholar

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© Humana Press, Totowa, NJ 1994

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  • T. Colin Campbell

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