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Error Prone Repair-Emphasis Weigle Reactivation

  • Thomas P. Coohill
Part of the NATO Conference Series book series (NATOCS, volume 7)

Abstract

There are several ways that living cells repair damage inflicted upon their genetic material (DNA) by ultraviolet light. The best understood, but by no means the only, type of photochemical damage is the dimerization of adjacent pyrimidine bases in the DNA chain, the most prevalent ones being thymine-thymine (TT) dimers. Almost certainly, we haven’t discovered all of the repair mechanisms present in cells. However, at present, three distinct types of repair are demonstrable;
  1. (1)

    dark repair

     
  2. (2)

    photoreactivation

     
  3. and (3)

    “error prone” repair

     

Keywords

Viral Reactivation Culture Passage Cell Culture Passage Mammalian Virus Dark Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bockstahler, L. E. and C. D. Lytle. 1970. UV enhanced reactivation of a mammalian virus. Biochem.Biophys. Res. Commun. 41: 184–189.CrossRefGoogle Scholar
  2. Coohill, T. P., L. C. James and S. P. Moore. 1978. The wavelength dependence of ultraviolet enhanced reactivation in a mammalian cell-virus system. Photochem. Photobi of. 27: 725–730.CrossRefGoogle Scholar
  3. Das Gupta, U. B. and W. C. Summers. 1978. UV reactivation of herpes simples virus is mutagenic and inducible in mammalian cells. Proc. Natl. Acad. Sci.USA 75: 2378–2381.CrossRefGoogle Scholar
  4. Devoret, R. 1978. Inducible error prone repair: one of the cellular responses to DNA damage. Biochimie 60: 1135–1140.CrossRefGoogle Scholar
  5. Gudas, L. J. and A. B. Pardee. 1975. Model for regulation of E. coli DNA repair functions. Proc Natl. Acad. Sci. USA 72:2330–2334.ADSCrossRefGoogle Scholar
  6. James, L. C. and T. P. Coohill. 1979. The wavelength dependence of 8-methoxypsoralen photosensitization of radiation enhanced reactivation in a mammalian cell-virus system. Mutat. Res. 62: 407–415.CrossRefGoogle Scholar
  7. Lytle, C. D., J. G. Goddard and Chen-ho-lin. 1980. Repair and mutagenesis of herpes simplex virus in UV radiated monkey cells. Mutat. Res.(In press).Google Scholar
  8. Moore, S. P. and T. P. Coohill. 1979. An effect of cell culture passage on ultraviolet enhanced viral reactivation by mammalian cells. Mutat. Res. 62: 417–423.CrossRefGoogle Scholar
  9. Radman, M. 1975. Molecular Mechanisms for Repair of DNA [ed. P. C. Hanawalt and R. B. Setlow], Plenum Press, part A, 355–368.CrossRefGoogle Scholar
  10. Rupert, C. S. and W. Harm. 1966. Advances in Radiation Biology, [ed. L. G. Augenstein and R. Maston]. 2, 1–81. Academic Press, N.Y.Google Scholar
  11. Weigle, J.J. 1953. Induction of mutations in a bacterial virus. Proc. Natl. Acad. Sci. USA 39: 628–636.ADSCrossRefGoogle Scholar
  12. Witkin, E. M. 1976. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteri ol. Rev. 40: 869–907Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Thomas P. Coohill
    • 1
  1. 1.Biophysics ProgramWestern Kentucky UniversityBowling GreenUSA

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