DNA Damage of the 5,6-Dihydroxydihydrothymine Type Induced by Solar UV-B in Human Cells

  • P. V. Hariharan
  • E. R. Blazek
Part of the NATO Conference Series book series (NATOCS, volume 7)


The magnitude of an acute skin dose of ionizing radiation which produces an abundance of 5,6-dihydroxydihydrothymine (t′) equal to that produced by a plausible daily exposure to solar UV (313±6 nm) is calculated to range from 0.27 krad (winter) to 5.65 krad (summer) in temperate latitudes. Considering the evidence for the possible biological importance of the t′ lesion, and the carcinogenicity of a 1.6 krad acute skin dose of ionizing radiation in one strain of rat, these t′ damage. equivalent doses emphasize the magnitude of the challenge presented by solar UV-B.


Basal Cell Carcinoma Pyrimidine Dimer Base Damage Chinese Hamster Lung Fibroblast Short Irradiation Period 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • P. V. Hariharan
    • 1
  • E. R. Blazek
    • 1
  1. 1.Department of BiophysicsRoswell Park Memorial InstituteBuffaloUSA

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