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Lethal Effects on Biological Systems Caused by Solar Ultraviolet Light: Molecular Considerations

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The Role of Solar Ultraviolet Radiation in Marine Ecosystems

Part of the book series: NATO Conference Series ((MARS,volume 7))

Abstract

The most closely examined organisms for the measurement of lethal effects of ultraviolet light are the bacteria, and the information we have regarding molecular events leading to cell death is almost entirely derived from work using these microbial systems. Speculations as to ultraviolet light effects upon higher, eukaryotic cells and multicellular organisms are largely extrapolations. A further limitation in our knowledge of ultraviolet effects is that most work has concentrated upon the actions of the most biologically efficient wavelengths below 300 nm (far ultraviolet light, FUV) which are not present in solar-UV reaching the surface of the earth. Further, ready availability has made 254 nm the most widely explored wavelength. Comparatively little emphasis has been placed upon the biologically inefficient, but ecologically important longer wavelengths above 300 nm (near ultraviolet light, NUV). These wavelengths are present in the solar ultraviolet reaching the surface of the earth and penetrating its waters. The following briefly summarizes some of the recent findings relating to the effects of NUV, especially upon bacterial cells and also transforming DNA, and compares these effects with the effects of FUV.

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References

  • Cabrera-Juarez, E. 1964. “Black light” inactivation of transforming deoxyribonucleic acid from Haemophilus influenzae. J. Bacteriol. 87:771–778.

    Google Scholar 

  • Cabrera-Juarez, E. and J. K. Setlow. 1980. Different Chromatographic behavior of a thymine-containing new ultraviolet photoproduct and spore photoproduct. Photochem. Photobiol. 31:603–606.

    Article  Google Scholar 

  • Cabrera-Juarez, E., J. K. Setlow, P. A. Swenson, and M. J. Peak. 1976. Oxygen-independent inactivation of Haemophilus influenzae transforming DNA by monochromatic radiation: Action spectrum, effect of histidine and repair, Photochem. Photobiol. 23: 309–314.

    Article  Google Scholar 

  • Coetzee, W. F., and E. C. Pollard. 1975. Near ultraviolet inactivation studies on Escherichia coli tryptophanase and tryptophan synthetase. Photochem. Photobiol. 22: 29–32.

    Google Scholar 

  • Elkind, M. M., and A. Han. 1978. DNA single strand lesions due to ‘sunlight’ and UV light: a comparison of their induction in Chinese hamster and human cells, and their fate in Chinese hamster cells. Photochem. Photobiol. 27: 717–724.

    Google Scholar 

  • Favre, A., M. Yaniv, and A. M. Mickelson. 1969. The photochemistry of 4-thiouridine in Escherichia coli t-RNAval, Biochem. Biophys. Res. Commun. 21: 266–271.

    Google Scholar 

  • Foote, C. S. 1978. Mechanisms of photooxidation. In Singlet Oxygen-Reactions with Organic Compounds and Polymers [B. Ranby and J. F. Rabeck, eds.] 135–146. John Wiley and Sons.

    Google Scholar 

  • Hanawalt, P. C., E. C. Friedberg, and C. F. Fox. 1978. DNA Repair Mechanisms, Academic Press, New York.

    Google Scholar 

  • Hariharan, P. V., and P. A. Cerutti. 1977. Formation of products of the 5,6-dihydroxydihydrothymine type by ultraviolet light in HeLa cells. Biochemistry 16: 2791–2795.

    Article  Google Scholar 

  • Jagger, J. 1967. Introduction to Research in Ultraviolet Photobiology, Prentice-Hall, Englewood Cliffs, N. J.

    Google Scholar 

  • Ley, R. D., B. A. Sedita, and E. Boye. 1978. DNA polymerase I-mediated repair of 365 nm-induced single strand breaks in the DNA of Escherichia coli. Photochem. Photobiol. 22:323–328.

    Google Scholar 

  • McGrath, R. A. and R. W. Williams. 1966. Reconstruction in vivo of irradiated E. coli deoxyribonucleic acid, the rejoining of broken pieces, Nature London 212: 534–535.

    Google Scholar 

  • Peak, M. J., J. G. Peak, and R. B. Webb. 1973a. Inactivation of transforming DNA by ultraviolet light.

    Google Scholar 

  • I. Near-UV action spectrum for marker inactivation. Mutat. Res. 20:129–135.

    Google Scholar 

  • Peak, M. J., J. G. Peak, and R. B. Webb. 1973b. Inactivation of transforming DNA by ultraviolet light. H. Protection by histidine against near-UV radiation: Action spectrum. Mutat. Res. 20: 137–141.

    Article  Google Scholar 

  • Peak, M. J., J. G. Peak, and R. B. Webb. 1973c. Inactivation of transforming DNA by ultraviolet light.III. Further observations on the effects of 365 nm radiation. Mutat. Res. 20: 143–148.

    Google Scholar 

  • Peak, M. J., and J. G. Peak. 1975. Protection by AET against inactivation of transforming DNA by nearultraviolet light: action spectrum. Photochem. Photobiol. 22: 147–148.

    Article  Google Scholar 

  • Peak, J. G., M. J. Peak, and C. S. Foote. 1981. Protection by DABCO against inactivation of transforming DNA by near-ultraviolet light: action spectra, and implications for involvement of singlet oxygen. Photochem. Photobiol. Yi: 45–49.

    Google Scholar 

  • Peak, M. J., and J. G. Peak. 1980. Protection by glycerol against the biological actions of near-ultraviolet light. Radiat. Res.: 553–558.

    Google Scholar 

  • Rahn, R. 0. 1978. Non-dimer damage in DNA caused by UV radiation [K. C. Smith, ed.]. Photobiological Reviews 4.

    Google Scholar 

  • Ramabhadran, T.V., and J. Jagger. 1976. Mechanism of growth delay induced in Escherichia coli by near ultraviolet radiation. Proc.Nat. Acad. Sci. USA 73: 59–69.

    Article  ADS  Google Scholar 

  • Robb, F. T., and M. J. Peak. 1979. Inactivation of the lactase permease of Escherichia coli by monochromatic ultraviolet light. Photochem. Photobiol. Q: 379–383.

    Google Scholar 

  • Setlow, J. K. 1962. Evidence for a particular base alteration in two T4 bacteriophage mutants. Nature 194: 664–666.

    Google Scholar 

  • Setlow, J. K. 1967. The effects of ultraviolet radiation and photoreactivation. Comprehensive Biochem. 22: 157–209.

    Google Scholar 

  • Setlow, J. K. and M. E. Boling. 1970. Ultraviolet action spectra for mutation in Escherichia coli. Mutat. Res. 9: 437–442.

    Article  Google Scholar 

  • Setlow, R. B. 1974. The wavelengths in sunlight effective in producing skin cancer: A theoretical analysis. Proc. Nat. Acad. Sci. USA 71: 3363–3366.

    Article  ADS  Google Scholar 

  • Smith, K. C. 1978. Multiple pathways of DNA repair in bacteria and their roles in mutagenesis. Photochem. Photobiol. 28: 121–130.

    Article  Google Scholar 

  • Thomas, G. and AT-Favre. 1975. 4-Thiouridine as the target for near-ultraviolet light induced growth delay in Escherichia coli, Biochem. Biophys. Res. Commun. 66: 1454–1461.

    Article  Google Scholar 

  • Turner, M. A. and R. B. Webb. 1981. Comparative muta-genesis and responses to near-UV (313–405 nm) and far UV (254 nm) radiation in strains of E. coli with differing repair capabilities. J. Bacteriol. 147: 00–00.

    Google Scholar 

  • Tuveson, R. W. 1980. Genetic control of near-UV sensitivity independent of excision deficiency (uvrA6) in E. coli K12, Photochem. Photobiol. 32: 703–705.

    Article  Google Scholar 

  • Tuveson, R. W., and M. E. March. 1980. Photodynamic and sunlight inactivation of Escherichia coli strains differing in near-UV sensitivity and recombination proficiency. Photochem. Photobiol. 31: 287–289.

    Article  Google Scholar 

  • Tyrrell, R. M. 1973. Induction of pyrimidine dimers in bacterial DNA by 365 nm radiation. Photochem. Photobiol. 17: 69–73.

    Article  Google Scholar 

  • Tyrrell, R. M. 1976. Rec A+-dependent synergism between 365 nm and ionizing radiation in log phase Escherichia coli: A model for oxygen dependent near UV inactivation by disruption of DNA repair, Photochem. Photobiol. z: 345–352.

    Google Scholar 

  • Tyrrell, R. M. 1980. Mutation induction by and mutational interaction between monochromatic radiations in the near-ultraviolet and visible ranges. Photochem. Photobiol. 1: 37–46.

    Article  Google Scholar 

  • Tyrrell, R. M., R. D. Ley, and R. B. Webb. 1974. Induction of single-strand breaks (alkali-labile bonds) in bacterial and phage DNA by near-UV (365 nm) radiation. Photochem. Photobiol. 20: 395–398.

    Article  Google Scholar 

  • Tyrrell, R. M. and R. B. Webb. 1973. Reduced dimer excision following near ultraviolet (365 nm) radiation. Mutat. Res. 19: 361–365.

    Google Scholar 

  • Tyrrell, R. M., R. B. Webb, and M. S. Brown. 1973. Destruction of photor.eactivating enzyme by 365 nm radiation. Photochem. Photobiol. 18: 249–254.

    Google Scholar 

  • Webb, R. B. 1977. Lethal and mutagenic effects of near ultraviolet radiation, In Photochemical and Photo-biological Reviews [K. C. Smith, ed.], Vol. 2, 169–261. Plenum Press, New York.

    Chapter  Google Scholar 

  • Webb, R. B., and M. S. Brown. 1976. Sensitivity of strains of Escherichia coli differing in repair capability to far UV, near UV and visible radiations. Photochem. Photobiol. 24:425–532.

    Article  Google Scholar 

  • Webb, R. B. and M. A. Turner. 1981. Mutation induction by monochromatic 254 nm and 365 nm radiation in strains of Escherichia coli that differ in repair capability. Mutat. Res.(In press).

    Google Scholar 

  • Webb, R. B., M. S. Brown, and R. M. Tyrrell. 1976. Lethal effects of pyrimidine dimers induced at 365 nm in strains of E. coli differing in repair capability. Mutat. Res. 37: 163–172.

    Article  Google Scholar 

  • Webb, R. B., M. S. Brown, and R. M. Tyrrell. 1978. Synergism between 365 and 254 nm radiations for inactivation of Escherichia coli. Radiat. Res.: 298–311.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Mutagenesis Group, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, 60439, USA

    Meyrick J. Peak & Jennifer G. Peak

Authors
  1. Meyrick J. Peak
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  2. Jennifer G. Peak
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Editor information

Editors and Affiliations

  1. Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, USA

    John Calkins

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© 1982 Plenum Press, New York

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Peak, M.J., Peak, J.G. (1982). Lethal Effects on Biological Systems Caused by Solar Ultraviolet Light: Molecular Considerations. In: Calkins, J. (eds) The Role of Solar Ultraviolet Radiation in Marine Ecosystems. NATO Conference Series, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8133-4_29

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  • DOI: https://doi.org/10.1007/978-1-4684-8133-4_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8135-8

  • Online ISBN: 978-1-4684-8133-4

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