The Membrane of the Hen Erythrocyte as a Model for Studies on Membrane Fusion

  • J. A. Lucy
Part of the Nobel Foundation Symposia book series (NOFS, volume 34)


This paper is primarily concerned with the molecular mechanisms and ultrastructural changes involved in the fusion of hen erythrocytes with one another to produce bi-, tri-and multinucleated cells. Related studies on liposomes and on monomolecular films of lipids and phospholipids will also be discussed.


Erythrocyte Membrane Cell Fusion Membrane Fusion Multinucleated Cell Polar Head Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Ahkongy 12,F., Cramp, F.C., Fisher, D., Howell, J.I. and Lucy, J.A. (1972) J1 Cell Sci. 10, 769–787Google Scholar
  2. Ahkongy Q’yFYy Fisher, D., Tampion, W. and Lucy, J.A. (1973a) Biochem.J 136 147–155Google Scholar
  3. Ahkongy Q.F.} Cramp, F.C., Fisher, D., Howell, J.I., Tampion, W., Verrindery My and Lucy, J.A. (1973b) Nature New Biol. 242, 215–217Google Scholar
  4. Ahkongy Q.F., Howell, J.I., Tampion, W. and Lucy, J.A. (1974) FEBS Lett. 41 206–110CrossRefGoogle Scholar
  5. Ahkongy Q.F. Fisher, D., Tampion, W. and Lucy, J.A. (1975a) Nature 253 194–195CrossRefGoogle Scholar
  6. Ahkong Q.FIy Howell, J.I., Lucy, J.A., Safwat, F., Davey, M.R. and Cocking- E.C, (1975b) Nature 255, 66–67CrossRefGoogle Scholar
  7. Ahkong, Q.F,, Tampion, W. and Lucy, J.A. (1975c) Nature 256, 208–209CrossRefGoogle Scholar
  8. Allant’ D,y Billah, M.M., Finean, J.B. and Michell, R.H. (1976) Natures in Press.Google Scholar
  9. Banghamy A,Dy and Horne, R.W. (1964) J. Mol. Biol. 8, 660–668CrossRefGoogle Scholar
  10. BatZriy S and Korn, E.D. (1975) J. Cell Biol. 66, 621–634CrossRefGoogle Scholar
  11. Bermejo; J Eirin, T. and Barbadillo, A. (1975) FEBS Lett. 58, 289–292PubMedCrossRefGoogle Scholar
  12. Blough, H,Ayy’Gallaher, W.R. and Weinstein, D.B. (1973) in Membrane Mediated Info±mation (Kent, P.W., ed), Vol. 1, pp. 183–199, Medical and Technical Publishing Co. Ltd., LancasterGoogle Scholar
  13. Breisblatt, W and Ohki, S. (1975) J. Membrane Biol. 23, 385–401CrossRefGoogle Scholar
  14. Carafoli E1) Clementi, F., Drabikowski, W. and Margreth, A., eds., (1975) Calcium Transport in Contraction and Secretion, pp. 588, North-Holland Publishing Co., AmsterdamGoogle Scholar
  15. Cater; B,Ry, Chapman, D., Hawes, S.M. and Saville, J. (1974) Biochim. Biophysr Acta 363, 54–69Google Scholar
  16. Cochrane, D.E, and Douglas, W.W. (1974) Proc. Nat. Acad. Sci. U.S. 71 408–412CrossRefGoogle Scholar
  17. Cramp, F.C( and Lucy; J.A. (1974) Exp. Cell Res. 87, 107–110CrossRefGoogle Scholar
  18. Croce, C.M., Sawicki, W., Kritchevski, D. and Koprowski, H. (1971) Exp. Cell Res, 67, 427–435PubMedCrossRefGoogle Scholar
  19. Dempsey; O,Pyy Bullivant, S. and Watkins, W.B. (1973) Z. Zellforsch 143 465–484CrossRefGoogle Scholar
  20. Eaton; J,WI; Skelton, T.D., Swofford, H.S., Kolpin, C.E. and Jacob, H.S. (1973) Nature 246, 105–106CrossRefGoogle Scholar
  21. Elgsaeter, A., Shotton, D.M. and Branton, D. (1976) Biochim, Biophys. Acta 426, 101–122Google Scholar
  22. Eisbach, P., Holmes, K.V. and Choppin, P.W. (1969) Prof Soc. Expo Biol. Med. 130, 903–908Google Scholar
  23. Falke, D., Schiefer, H-G. and Stoffel, W. (1967) Z. Naturforsch 22b, 1360–1362Google Scholar
  24. Fisher, D. (1975) in NATO Symposium on Lipids, Protens and Receptors (Burton, R.M. and Packer, L., eds.), pp 75–93 Bi-Science Publications Division, Webster Groves, MissouriGoogle Scholar
  25. Foreman, J.C., Mongar, J.L. and Gomperts, B.D. (1973) Nature 245, 249–251PubMedCrossRefGoogle Scholar
  26. Furusawa, M., Nishimura, T., Yamaizumi, M. and Okada, Y, (1974) Nature 249, 449–450PubMedCrossRefGoogle Scholar
  27. Gledhill, B.L., Sawicki, W., Croce, C.M. and Koprgwskif H1 (1972) Exp. Cell Res. 73, 33–40Google Scholar
  28. Grant, C.W.M. and McConnell, H.M. (1974) Proc. Nat. Acad, Soil U,S, 71, 4653–4657CrossRefGoogle Scholar
  29. Hart, C.A., Ahkong, Q.F., Fisher, D., Hallinan, TI, Quirk, S1J, and Lucy, J.A. (1975) Biochem. Soc. Trans. 3, 734–736PubMedGoogle Scholar
  30. Haywood, A.M. (1974) J. Mol. Biol. 87, 625–628PubMedCrossRefGoogle Scholar
  31. Howell, J.I., Fisher, D., Goodall, A.H., Verrinder, 1, and Lucy, J,A, (1973) Biochim. Biophys. Acta 332, 1–10Google Scholar
  32. Howell, J.I. and Lucy, J.A. (1969) FEES Lett. 4, 147–150CrossRefGoogle Scholar
  33. Jacob, H.S. (1975) in Cell Membranes: Biochemistry, Cell biology and Pathology (Weissmann, G. and Claiborne, R,, eds,), pp, 249–255, H.P. Publishing Co. Inc. New YorkGoogle Scholar
  34. Jendrasiak, G.L. and Hasty, J.H. (1974) Biochim. Bi.ophys„ Acta 337; 79–91Google Scholar
  35. Kantor, H.L. and Prestegard, J.H. (1975) Biochemistry 14 1790–1795PubMedCrossRefGoogle Scholar
  36. Keay, L., Weiss, S.A., Circulis, N. and Wildi, B.S, (1972) In vitro 8, 19–25PubMedCrossRefGoogle Scholar
  37. Kent, C. and Vagelos, P.R. (1975) Fed. Froc. 34, 525Google Scholar
  38. Kosower, N.S., Kosower, T.M. and Wegman, P. (1975) Biochim, Biophys, Acta 401, 530–534Google Scholar
  39. Lau, A.L.Y. and Chan, S.I. (1975) Proc. Nat. Acad, Sci, u,S, 72, 2170–2174CrossRefGoogle Scholar
  40. Lawaczek, R., Kainosho, M., Girardet, J-L. and Chan, 4,11 (1975) Nature 256, 584–586Google Scholar
  41. Lawson, D., Gilula, N.B., Fewtrell, C., Gomperts, BO?, and Raffa MIC, (1976) in 33rd Nobel Symposium: Molecular and biological aspects of the acute allergic reaction, in press, Plenum Publishing Co. Ltd., LondonGoogle Scholar
  42. Loyter, A., Zakai, N. and Kulka, R.G. (1975) J. Cell Biolt 66, 292–304Google Scholar
  43. Lucy, J.A. (1970) Nature 227, 814–817CrossRefGoogle Scholar
  44. Lucy, J.A. 1975 ) J. Reprod. Fert. 44, 193–205CrossRefGoogle Scholar
  45. Lucy, J.A. 1976) in 2nd NATO Advanced Study Institute on the Biliary System (Taylor, W., ed), in press, Plenum Publishing Co. Ltd., LondonGoogle Scholar
  46. Maggio, B. and Lucy, J.A. (1975) Biochem. J. 149, 597–608PubMedGoogle Scholar
  47. Maggio, B. and Lucy, J.A. (1976) Biochem. J. 155, 353–364PubMedGoogle Scholar
  48. Maroudas, N.G. (1975) Nature 254, 695–696PubMedCrossRefGoogle Scholar
  49. Martin, F. and MacDonald, R. (1974) Nature 252, 161–163PubMedCrossRefGoogle Scholar
  50. McIntyre, J.A., Gilula, N.B. and Karnovsky, M.J. (1974) J. Cell Biol. 60, 192–203PubMedCrossRefGoogle Scholar
  51. Metcalfe, J.C., Seeman, P. and Burgen, A.S.V. (1968) Mol. Pharmacol. 4, 87–95PubMedGoogle Scholar
  52. Ohnishi, S-I. and Ito, T. (1974) Biochemistry 13, 881–887CrossRefGoogle Scholar
  53. Pagano, R.E., Huang, L. and Wey, C. (1974) Nature 252, 166–167PubMedCrossRefGoogle Scholar
  54. Papahadjopoulos, D., Poste, G. and Schaeffer, B.E. (1973) Biochim. Biophys. Acta 323, 23–42CrossRefGoogle Scholar
  55. Papahadjopoulos, D., Poste, G. and Mayhew, E. (1974a) Biochim. Biophys. Acta 363, 404–418CrossRefGoogle Scholar
  56. Papahadjopoulos, D., Mayhew, E., Poste, G., Smith, S. and Vail, W.J. (1974b) Nature 252, 163–165PubMedCrossRefGoogle Scholar
  57. Papahadjopoulos, D., Poste, G., Schaeffer, B.E. and Vail, W.J. (1974c) Biochim. Biophys. Acta 352, 10–28CrossRefGoogle Scholar
  58. Parkes, J.G. and Fox, C.F. (1975) Biochemistry 14, 3725–3729PubMedCrossRefGoogle Scholar
  59. Pasternak, C.A. and Micklem, K.J. (1974) Biochem. J. 140, 405–411PubMedGoogle Scholar
  60. Peretz, H., Toister, Z., Laster, Y. and Loyter, A. (1974) J. Cell Biol. 63, 1–11PubMedCrossRefGoogle Scholar
  61. Phillips, M.C., Finer, E.G. and Hauser, H. (1972) Biochim. Biophys. Acta 290, 397–402CrossRefGoogle Scholar
  62. Pinto da Silva, P. and Martinez-Palomo, A. (1974) Nature 249, 170–171PubMedCrossRefGoogle Scholar
  63. Pontecorvo, G. (1975) Somatic Cell Genetics 1, 397–400PubMedCrossRefGoogle Scholar
  64. Poole, A.R., Howell, J.I. and Lucy, J.A. (1970) Nature 227, 810–813PubMedCrossRefGoogle Scholar
  65. Poste, G. and Allison, A.C. (1973) Biochim. Biophys. Acta 300, 421–465Google Scholar
  66. Pressman, B.C. Fed. Proc. (1973) 32, 1698–1701PubMedGoogle Scholar
  67. Prestegard, J.H. and Fellmeth, B. (1974) Biochemistry 13, 1122–1126PubMedCrossRefGoogle Scholar
  68. Reed, P.W. and Lardy, H.A. (1972) in The Role of Membranes in Metabolic Regulation (Mehlman, M.A. and Hanson, R.W., eds.), pp. 111–131, Academic Press, New YorkGoogle Scholar
  69. Reporter, M. and Norris, G. (1973) Differentiation 1, 83–95CrossRefGoogle Scholar
  70. Satir, B., Schooley, C. and Satir, P. (1973) J. Cell Biol. 56, 153–176Google Scholar
  71. Seelig, A. and Seelig, J. (1974) Biochemistry 13, 4839–4845PubMedCrossRefGoogle Scholar
  72. Shainberg, A., Yagil, G. and Yaffe, D. (1969) Exp. Cell Res. 58, 163–167PubMedCrossRefGoogle Scholar
  73. Steck, T.L. (1974) J. Cell Biol. 62, 1–19PubMedCrossRefGoogle Scholar
  74. Suzuki, Y. and Matsumoto, M. (1974) Biochem. Biophys. Res. Commun. 41, 505–512CrossRefGoogle Scholar
  75. Traiible, H. and Haynes, D.H. (1971) Chem. Phys. Lipids 7, 324–335CrossRefGoogle Scholar
  76. van der Bosch, J. and McConnell, H.M. (1975) Proc. Nat. Acad. Sci. U.S. 72, 4409–4413CrossRefGoogle Scholar
  77. Vollet, J.J. and Roth, L.E. (1974) Cytobiologie 9, 249–262Google Scholar
  78. Whitehouse, M.W.,•Orr, K.J., Beck, F.W.J. and Pearson, C.M. (1974) Immunology 27, 311–330Google Scholar
  79. Zentgraf, H., Deumling, B., Jarasch, E-D. and Franke, W.W. (1971) J. Biol. Chem. 246, 2986–2995PubMedGoogle Scholar
  80. Zwaal, R.F.S., Roelofsen, B. and Colley, C.M. (1973) Biochim. Biophys. Acta 300, 159–182PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • J. A. Lucy
    • 1
  1. 1.Department of Biochemistry and Chemistry, Royal Free Hospital School of MedicineUniversity of LondonLondonUK

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