Alterations in the Renal Medullary and Papillary Interstitial Cells in Experimental and Spontaneous (Essential) Hypertension

  • Anil K. Mandal
  • John A. Nordquist


It is reasonably well established that renal medulla and papilla of animals (rat, dog, rabbit) contain vasodepressor or antihypertensive substances that consistently reduce blood pressure in hypertensive animals (Muirhead, 1976). Much indirect evidence points toward the presence of similar vasodepressor substance(s) in human kidneys (Muehrcke et al., 1970; Prezyna et al., 1973; Mandal et al., 1979). This hypothesis is further supported by the finding of large amounts of prostaglandins in human renal papilla (Vance et al., 1973). However, the question of where in the papilla the vasodepressor substances are synthesized and/or stored has yet to be completely resolved. Within the papilla exist many interstitial cells that appear to be secretory, since they contain dilated endoplasmic reticulum, ribosomes, and conspicuous granules. These renal papillary interstitial cells (RIC) are considered by many to be the most probable site for the formation of vasodepressor substance(s). Furthermore, the location of the RIC, juxtaposed as they are between the tubules and the peritubular capillaries, strongly supports this proposed function.


Interstitial Cell Free Interstitium Layered Granule Renal Papilla Intracellular Granule 
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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Anil K. Mandal
    • 1
  • John A. Nordquist
    • 2
  1. 1.Department of MedicineVeterans Administration Medical Center and University of Oklahoma College of MedicineOklahoma CityUSA
  2. 2.Renal Electron Microscopy LaboratoryVeterans Administration Medical CenterOklahoma CityUSA

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