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Renal Prostaglandin Synthesis and Metabolism in Normal and Hypertensive States

  • Catherine Limas

Abstract

The impetus for studying prostaglandin synthesis and metabolism in hypertension derives largely from a consideration of their effects on the vascular system and the kidney. Through their actions on the vascular smooth muscle and water and electrolyte exchange in the kidney, prostaglandins may participate in the control of systemic blood pressure under physiological and/or pathological conditions.

Keywords

Prostaglandin Synthesis Renal Medulla Precursor Fatty Acid Renal Papilla Renal Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abe, K., Saito, T., Otsuka, Y., Seino, M., and Yasujima, M., 1976, An evaluation of plasma and renal prostaglandins in hypertension, in: Advances in Prostaglandin and Thromboxane Research, Vol. 2 ( B. Samuelsson and R. Paoletti, eds.), Raven Press, New York, p. 599.Google Scholar
  2. Ahnfeld-Ronne, I., and Arrigoni-Martelli, E., 1977, Renal prostaglandin metabolism in spontaneously hypertensive rats, Biochem. Pharmacol. 26: 485.CrossRefGoogle Scholar
  3. Altura, B. M., and Altura, B. T., 1976, Vascular smooth muscle and prostaglandins, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 2360.Google Scholar
  4. Änggârd, E., Bohman, S.-O., Griffin, J. E., III, Larsson, C., and Maunsbach, A. B., 1972, Subcellular localization of the prostaglandin system in the rabbit renal papilla, Acta Physiol. Scand. 85: 237.CrossRefGoogle Scholar
  5. Armstrong, J. M., Blackwell, G. J., Flower, R. J., McGiff, J. C., Mullane, K. M., and Vane, J. R., 1976, Genetic hypertension in rats is accompanied by a defect in renal prostaglandin metabolism, Nature 260: 582.PubMedCrossRefGoogle Scholar
  6. Baudouin, M., Meyer, P., Fermandjian, S., and Morgat, J. L., 1972, Calcium release induced by interaction of angiotensin with its receptors in smooth muscle cell microsomes, Nature 235: 336.PubMedCrossRefGoogle Scholar
  7. Berl, P., Raz, A., Wald, H., Horowits, J., and Czaczkes, W., 1977, Prostaglandin synthesis inhibition and the action of vasopressin: Studies in man and rat, Am. J. Physiol. 232: F529.PubMedGoogle Scholar
  8. Blackwell, G. J., Flower, R. J., and Vane, J. R., 1975, Some characteristics of the prostaglandin synthesizing system in rabbit kidney microsomes, Biochim. Biophys. Acta 398: 178.PubMedGoogle Scholar
  9. Bohman, S.-O., 1977, Demonstration of prostaglandin synthesis in collecting duct cells and other cell types of the rabbit renal medulla,Prostaglandins 14: 729.Google Scholar
  10. Bohman, S.-O., and Larsson, C., 1975, Prostaglandin synthesis in membrane fractions from rabbit renal medulla, Acta Physiol. Scand. 94: 244.PubMedCrossRefGoogle Scholar
  11. Cook, H. W., and Lands, W. E. M., 1975, Evidence for an activating factor formed during prostaglandin biosynthesis, Biochem. Biophys. Res. Commun. 65: 464.PubMedCrossRefGoogle Scholar
  12. Crowshaw, K., 1973, The incorporation of [1-l’C]arachidonic acid into the lipids of rabbit renal slices and conversion to prostaglandins E2 and F2., Prostaglandins 3: 607.PubMedCrossRefGoogle Scholar
  13. Danon, A., Chang, L. C., Sweetman, S. J., Nies, A. S., and Oates, J. A., 1975a, Synthesis of prostaglandins by the rat renal papilla in vitro; mechanism of stimulation by angiotensin II, Biochim. Biophys. Acta 388: 71.PubMedGoogle Scholar
  14. Danon, A., Heimberg, M., and Oates, J. A., 1975, Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors, Biochim. Biophys. Acta 388: 318.PubMedGoogle Scholar
  15. Davis, H. A., and Horton, E. W., 1972, Output of prostaglandins from the rabbit kidney, its increase on renal nerve stimulation and its inhibition by indomethacin, Br. J. Pharmacol. 46: 658.PubMedGoogle Scholar
  16. DeRubertis, F. R., Zenser, T. V., Craven, P. A., and Davis, B. B., 1976, Modulation of the cyclic AMP content of rat renal inner medulla by oxygen: Possible role of local prostaglandins, J. Clin. Invest. 58: 1370.PubMedCrossRefGoogle Scholar
  17. Donker, A. J., Ausz, L., Brentjens, J. R., Van DerHem, G. K., and Hollemans, H. J., 1976, The effect of indomethacin on kidney function and plasma renin activity in man, Nephron 17: 288.PubMedCrossRefGoogle Scholar
  18. Dunn, M. J., 1976, Renal prostaglandin synthesis in the spontaneously hypertensive rat, J. Clin. Invest. 58: 862.PubMedCrossRefGoogle Scholar
  19. Feigen, L. P., Klainer, E., Chapnick, B. M., and Kadowitz, P. J., 1976, The effect of indomethacin on renal function in pentobarbital-anesthetized dogs, J. Pharmacol. Exp. Ther. 198: 457.PubMedGoogle Scholar
  20. Ferreira, S. H., and Vane, J. R., 1967, Prostaglandins: Their disappearance from and release into the circulation, Nature 216: 868.PubMedCrossRefGoogle Scholar
  21. Flower, R. J., and Blackwell, G. J., 1976, Importance of phospholipase A2 in prostaglandin biosynthesis, Biochem. Pharmacol. 25: 285.PubMedCrossRefGoogle Scholar
  22. Fourman, J., and Moffat, D. B., 1971, Blood Vessels of the Kidney, Oxford, Blackwell Scientific Publications, p. 58.Google Scholar
  23. Frölich, J. C., Wilson, T. W., Sweetman, B. J., Smigel, M., Nies, A. S., Carr, K., Watson, J. T., and Oates, J. A., 1975, Urinary prostaglandins: Identification and origin, J. Clin. Invest. 55: 763.PubMedCrossRefGoogle Scholar
  24. Fulgraff, G., and Brandenbusch, G., 1974, Comparison of the effects of the prostaglandins At, E2, and Fla on kidney function in dogs, Pfluegers Arch. 349: 9.CrossRefGoogle Scholar
  25. Gerber, J. G., Ellis, E. F., and Nies, A. S., 1977, The effect of endoperoxide analogues on renal function and hemodynamics, Fed. Proc. Fed. Am. Soc. Exp. Biol. 36: 402.Google Scholar
  26. Granström, G., and Kindahl, H., 1976, Radioimmunoassay for urinary metabolites of prosta-glandin F22, Prostaglandins 12: 759.PubMedCrossRefGoogle Scholar
  27. Grantham, J. J., and Orloff, J., 1968, Effect of prostaglandin E, on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3’,5’-monophosphate, and theophylline, J. Clin. Invest. 47: 1154.PubMedCrossRefGoogle Scholar
  28. Greenberg, S., 1976, Evidence for enhanced venous smooth muscle turnover of prostaglandin-like substance in portal veins from spontaneously hypertensive rats, Prostaglandins 11: 163.PubMedCrossRefGoogle Scholar
  29. Grodzinska, L., Schor, K., Wartner, V., Forster, W., and Gryglewski, R., 1974, Prostaglandin synthesis activity in the renal medulla of normal and hypertensive rats, Pol. J. Pharmacol. Pharm. 26: 229.Google Scholar
  30. Hagenfeldt, L., and Warner, J., 1975, Turnover of plasma free arachidonic and oleic acids in resting and exercising human subjects, Metabolism 24: 799.PubMedCrossRefGoogle Scholar
  31. Hemler, M. E., and Lands, N. E. M., 1977, Biosynthesis of prostaglandins, Lipids 13: 591.CrossRefGoogle Scholar
  32. Hohenleitner, F. J. and Spitzer, J. J., 1961, Changes in plasma free fatty acid concentrations on passage through the dog kidney, Am. J. Physiol. 200: 1095.PubMedGoogle Scholar
  33. Hornych, A., Bedrossian, J., Bariety, J., Menard, J., Corvol, P. Safar, M., Fontaliran, F., and Fillier, P., 1975, Prostaglandins and hypertension in chronic renal diseases, Clin. Nephrol. 4: 144.PubMedGoogle Scholar
  34. Hornych, A., Safar, M., Weiss, Y., Menard, J., Corvol, P., Bariety, J., and Millez, P., 1976a, Prostaglandins and essential hypertension, Eur. J. Clin. Invest. 6: 314.Google Scholar
  35. Hornych, A., Weiss, Y., Safar, M., Menard, J., Corvol, P., Fontaliran, E., Bariety, J., and Milliez, P., 1976b, Prostaglandins A and B in the peripheral blood of hypertensive patients, Prostaglandins 12: 383.PubMedCrossRefGoogle Scholar
  36. Isakson, P. C., Raz, A., and Needleman, P., 1976, Selective incorporation of “C-prostaglandins, Prostaglandins 12: 739.PubMedCrossRefGoogle Scholar
  37. Itskovitz, H. D., Terragno, N. A., and McGiff, J. C., 1974, Effect of a renal prostaglandin on distribution of blood flow in the isolated kidney, Circ. Res. 34: 770.PubMedGoogle Scholar
  38. Katzen, D. R., Pong, S. S., and Levine, L., 1975, Distribution of prostaglandin E 9ketoreductase and NAD -dependent and NADP-dependent 15-hydroxyprostaglandin dehydrogenase in the renal cortex and medulla of various species, Res. Commun. Chem. Pathol. Pharmacol. 12: 781.PubMedGoogle Scholar
  39. Kauker, M. L., 1977, Prostaglandin E2 effect from the luminal side on renal tubular “Na efflux: Tracer microinjection studies, Proc. Soc. Exp. Biol. Med. 154: 272.Google Scholar
  40. Knapp, H. R., Oelz, O., Roberts, L. J., Sweetman, B. J., Oates, J. A., and Reed, P. W., 1977, Ionophores stimulate prostaglandin and thromboxane biosynthesis, Proc. Natl. Acad. Sci. USA 74: 4251.PubMedCrossRefGoogle Scholar
  41. Kunze, H., Bohn, E., and Vogt, W., 1974, Effects of local anesthetics on prostaglandin biosynthesis in vitro, Biochim. Biophys. Acta 360: 260.PubMedGoogle Scholar
  42. Lands, W. E. M., and Samuelsson B., 1968, Phospholipid precursors of prostaglandins, Biochim. Biophys. Acta 164: 426.PubMedGoogle Scholar
  43. Larsson, C., and Anggard, E., 1974, Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney, Eur. J. Pharmacol. 21: 30.CrossRefGoogle Scholar
  44. Leary, W. P., Ledingham, J. G., and Vane, J. R., 1974, Impaired prostaglandin release from the kidneys of salt-loaded and hypertensive rats, Prostaglandins 7: 425.PubMedCrossRefGoogle Scholar
  45. Lee, S. C., and Levine, L., 1974, Prostaglandin metabolism I. Cytoplasmic reduced nicotinamide adenine dinucleotide phosphate-dependent and microsomal reduced nicotinamide adenine dinucleotide-dependent prostaglandin E 9-ketoreductase activities in monkey and pigeon tissues, J. Biol. Chem. 249: 1369.PubMedGoogle Scholar
  46. Limas, C., and Limas, C. J., 1979, Enhanced renomedullary prostaglandin synthesis in SHRs: Possible role of a membrane phospholipase, Am. J. Physiol. 236: H65.PubMedGoogle Scholar
  47. Limas, C., Limas, C. J., and Gesell, M, 1976a, Effects of indomethacin on renomedullary interstitial cells, Lab. Invest. 34: 522.PubMedGoogle Scholar
  48. Limas, C., Limas, C. J., Ragan, D., and Freis, E. D., 1976b, Renomedullary interstitial cells in the spontaneously hypertensive rat, Lab. Invest. 34: 606.PubMedGoogle Scholar
  49. Limas, C. J., and Limas, C., I977a, Prostaglandin metabolism in the kidneys of spontaneously hypertensive rats, Am. J. Physiol. 233: H87.Google Scholar
  50. Limas, C. J., and Limas, C., 1977b, Vascular prostaglandin synthesis in the spontaneously hypertensive rat, Am. J. Physiol. 233: H493.PubMedGoogle Scholar
  51. Lum, G. M., Aisenbrey, G. A., Dunn, M. J., Berl, T., Schrier, R. W., and McDonald, K. M., 1977, In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin, J. Clin. Invest. 59: 8.Google Scholar
  52. McGiff, J. C., 1978, Prostaglandins and the kidney, Contrib. Nephrol. 13: 461.Google Scholar
  53. Maclouf, J., Sors, H., and Rigaud, M., 1977, Recent aspects of prostaglandin biosynthesis. A review, Biomedicine 26: 362.PubMedGoogle Scholar
  54. Messing, E. J., Weiner, R., and Kaley, G., 1976, Prostaglandins and local circulatory control, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 2367.Google Scholar
  55. Morita, I., and Murota, S. I., 1979, Tissue specific regulation of prostagland in production. Stimulation of 6-ketoprostaglandin F,a biosynthesis by rat kidney cytosol, Biochim. Biophys. Acta 582:173.PubMedCrossRefGoogle Scholar
  56. Morrison, A. R., Moritz, H., and Needleman, P., 1978, Mechanisms of enhanced renal prostaglandin biosynthesis in uteteral obstruction. Role of de novo protein synthesis, J. Biol. Chem. 253: 8210.PubMedGoogle Scholar
  57. Muirhead, E. E., Germain, G., Leach, B. E., Pitcock, J. A., Stephenson, P., Brooks, B., Brosius, W. L., Daniels, E. G., and Ninman, J. W., 1972, Production of renomedullary prostaglandins by interstitial cells grown in tissue culture, Circ. Res. 31 (Suppl. 2): 161.PubMedGoogle Scholar
  58. Müller, M. M., Kaiser, E., Bauer, P., Scheiber, V., and Hohenegger, M., 1976, Lipid composition of the rat kidney, Nephron 17: 41.PubMedCrossRefGoogle Scholar
  59. Needleman, P., Kauffman, A. H., Douglas, J. R., Jr, Johnson, E. M., Jr, and Marshall, G. R., 1973, Specific stimulation and inhibition of renal prostaglandin release by angiotensin analysis, Am. J. Physiol. 224: 1415.PubMedGoogle Scholar
  60. Nekrasova, A. A., and Lantsberg, L. A., 1969, Role of renal prostaglandins in the pathogenesis of hypertension, Kardiologiya 9: 86.PubMedGoogle Scholar
  61. Nekrasova, A. A., Paleseva, F. M., and Khundadze, S. S., 1970, Content of depressor prostaglandin-like substances and renin activity in the kidneys of patients with renovascular hypertension, Kardiologiya 10: 88.PubMedGoogle Scholar
  62. Ogino, N., Miyamoto, T., Yamamoto, S., Hayaishi, O., 1977, Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme, J. Biol. Chem. 252: 890.PubMedGoogle Scholar
  63. Pace-Asciak, C., 1975a, Prostaglandin 9-hydroxydehydrogenase activity in the adult rat kidney, J. Biol. Chem. 250: 2789.PubMedGoogle Scholar
  64. Pace-Asciak, C., 1975b, Activity profiles of prostaglandin 15- and 9-hydroxydehydrogenase and 13-reductase in the developing rat kidney, J. Biol. Chem. 250: 2795.PubMedGoogle Scholar
  65. Pace-Asciak, C., 1976, Decreased renal prostaglandin catabolism precedes onset of hypertension in the developing spontaneously hypertensive rat, Nature 263: 510.PubMedCrossRefGoogle Scholar
  66. Pace-Asciak, C. R., Carrara, M. C., Rangaraj, G., and Nicolaou, K. C., 1978, Enhanced formation of PGI2, a potent hypotensive substance, by aortic rings and homogenates of the spontaneously hypertensive rat, Prostaglandins 15: 1005.PubMedCrossRefGoogle Scholar
  67. Papanicolaou, N., Mountokalakis, T., Safar, M., Bariety, J., and Milliez, P., 1976, Deficiency of renomedullary prostaglandin synthesis related to the evolution of essential hypertension, Experientia 32: 1015.PubMedCrossRefGoogle Scholar
  68. Pong, S. S., and Levine, L., 1976, Biosynthesis of prostaglandins in rabbit renal cortex, Res. Commun. Chem. Pathol. Pharmacol. 13: 115.PubMedGoogle Scholar
  69. Pugsley, D. J., Beilin, L. F., and Reto, R., 1975, Renal prostaglandin synthesis in the Goldblatt hypertensive rat, Circ. Res. 36–37 (Suppl. 1): 81.Google Scholar
  70. Quirion, R., Rioux, F., and Regoli, D., 1978, Effects of arachidonic acid and indomethacin on the in vitro release of prostaglandins by aortic strips of spontaneously hypertensive rats, Can. J. Physiol. Pharmacol. 56: 509.PubMedCrossRefGoogle Scholar
  71. Rioux, F., Quiron, R., and Regoli, D., 1977, The role of prostaglandins in hypertension: I. The release of prostaglandins by aorta strips of renal, DOCA—salt, and spontaneously hypertensive rats, Can. J. Physiol. Pharmacol. 55: 1330.PubMedCrossRefGoogle Scholar
  72. Ripka, O., Kucerova, K., Linhartova, J., Ort, J., and Peleska, J., 1976, Radioimmunoassay of renal venous prostaglandins in essential hypertension, Acta. Biol. Med. Ger. 35: 1221.PubMedGoogle Scholar
  73. Samuelsson, B., Granström, E., Green, K., Hamberg, M.., and Hammaratröm, S., 1978, Prostaglandins, Annu. Rev. Biochem. 44: 669.CrossRefGoogle Scholar
  74. Schick, P. K., Kuricka, K., and Chacko, G. K., 1975, Structural organization of platelet membrane phospholipids, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34: 126.Google Scholar
  75. Sirois, P., and Gagnon, D. J., 1974, Release of renomedullary prostaglandins in normal and hypertensive rats, Experientia 30: 1418.PubMedCrossRefGoogle Scholar
  76. Smith, G. W., and Somova, L. I., 1976, Renal function and renal venous prostaglandin concentrations during different stages of experimental renal hypertension in the rat, Br. J. Pharmacol. 58: 253.PubMedGoogle Scholar
  77. Stokes, J. B. and Kokko, J. P., 1977, Inhibition of sodium transport by prostaglandin E2 across the isolated, perfused rabbit collecting tubule, J. Clin. Invest. 59: 1099.PubMedCrossRefGoogle Scholar
  78. Stygles, V. G., Reinke, D. A., and Hook, J. B., 1976, Prostaglandin E2 production by renomedullary tissue of DOCA, Goldblatt, and spontaneously hypertensive rats, Res. Commun. Chem. Pathol. Pharmacol. 15: 753.PubMedGoogle Scholar
  79. Stygles, V. G., Reinke, D. A., Rickert, D. E., and Hook, J. B., 1977, Increased blood pressure in the SHR is not related to a deficit in renomedullary PGE2, Experientia 34: 1025.CrossRefGoogle Scholar
  80. Stygles, V. G., Smith, W. L., Reinke, D. A, and Hook, J. B., 1978, Prostaglandin-forming cyclooxygenase in renal medulla of spontaneously hypertensive rats during development, Biol. Neonate 33: 709.Google Scholar
  81. Swain, J. A., Heyndricks, G. R., Boettcher, D. H., and Vatner, S. F., 1975, Prostaglandin con- trol of renal circulation in the unanesthetized dog and baboon, Am. J. Physiol. 229: 826.PubMedGoogle Scholar
  82. Tai, H. H., Tai, C. W., and Hollander, C. S., 1976, Biosynthesis of prostaglandins in rabbit kidney medulla, Biochem. J. 154: 257.PubMedGoogle Scholar
  83. Tan, S. Y., Sweet, P., and Mulrow, P. J., 1978, Impaired renal production of PGE2: A newly identified lesion in human essential hypertension, Prostaglandins 15: 139.PubMedCrossRefGoogle Scholar
  84. Tandon, A. K., Singh, R. H., and Udupa, K. N., 1978, Plasma prostaglandins in essential hypertension and ischemic heart disease, Indian J. Med. Res. 67: 490.PubMedGoogle Scholar
  85. Terragno, D. A., Crowshaw, K., Terragno, N. A., and McGiff, J. C., 1975, Prostaglandin synthesis by bovine mesenteric arteries and veins, Cire. Res. 36–37 (Suppl. 1): 76.Google Scholar
  86. Tobian, L., and Azar, S., 1971, Antihypertensive and other function of the renal papilla, Trans. Assoc. Am. Phys. 84: 281.PubMedGoogle Scholar
  87. Van derOuderaa, F. J., Buytenhek, M., Slikkerveer, F. J., and Van Dorp, D. A., 1979, On the haemoprotein character of prostaglandin endoperoxide synthetase, Biochim. Biophys. Acta 572: 29.Google Scholar
  88. Vonkeman, H., and Van Dorp, D. A., 1968, The action of prostaglandin synthetase on 2arachidonyl lecithin, Biochim. Biophys. Acta 164: 430.PubMedGoogle Scholar
  89. Whorton, A. R., Smigel, M., Oates, J. A., and Frölich, J. C., 1978, Regional differences in prostacyclin formation by the kidney. Prostacyclin is a major prostaglandin of renal cortex, Biochim Biophys. Acta 529: 176.PubMedGoogle Scholar
  90. Zenser, T. V., and Davis, B. B., 1978, Effects of calcium on prostaglandin E2 synthesis by rat inner medullary slices, Am. J. Physiol. 235: F213.PubMedGoogle Scholar
  91. Zusman, R. M. and Keiser, H. R., 1977, Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture, J. Clin. Invest. 60: 215.PubMedCrossRefGoogle Scholar
  92. Zusman, R. M., Forman, B. H., Schneider, G., Caldwell, B. R., Speroff, L., and Mulrow, P. J., 1973, The effect of chronic sodium loading and sodium restriction on plasma and renal concentrations of prostaglandin A in normal Wistar and spontaneously hypertensive Aoki rats, Clin. Sci. 45: 325s.Google Scholar

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© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Catherine Limas
    • 1
  1. 1.Department of Pathology, Veterans Administration Hospital, and Departments of Laboratory Medicine and PathologyUniversity of Minnesota School of MedicineMinneapolisUSA

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