Vasodepressor Substances Extractable from Kidney Tissue

  • Basab K. Mookerjee
  • Ram V. Patak


The concept that the kidneys exert two independent and opposing influences on the regulation of arterial blood pressure was formulated following the publication of the classical Goldblatt experiment (Goldblatt et al., 1934; Fasciolo et al., 1938; Braun-Menendez, 1958; Braun-Menendez and von Euler, 1947). The renal prohypertensive function conducive to the development of hypertension is thought to be related to at least two functional attributes of the kidneys, namely the retention of sodium and water, and the activation of the renin–angiotensin system. The renal antihypertensive function may also be exerted by a similar dual mechanism, e.g., the relief of sodium–volume loads brought about by renal excretion (natriuresis and diuresis) and probably also by activation of endocrine-type mechanisms that may act locally within the kidneys and possibly systemically on the peripheral vasculature as well (Grollman, 1959; Muirhead et al., 1975).


Renal Blood Flow Renovascular Hypertension Blood Pressure Regulation Renal Medulla Renin Inhibitor 


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  1. Adetuyibi, A., and Mills, I. H., 1972, Relation between Kallikrein and renal function, hypertension and excretion of sodium and water in man, Lancet 2: 203.PubMedGoogle Scholar
  2. Barraclough, M. A., and Mills, I. H., 1965, Effects of bradykinin on renal function, Clin. Sci. 28: 69.PubMedGoogle Scholar
  3. Bergstrom, S., Carlson, L. A., Eklund, L. G., and Oro, L., 1965, Cardio-vascular and metabolic response of PGE, in man, Acta Physiol. Scand. 64: 332.PubMedGoogle Scholar
  4. Boucher, R. Veyrat, R., DeChamplain, D., and Genest, J., 1964, The measurement of renin by means of a new sensitive technique, Can. Med. Assoc. J. 6:1572.Google Scholar
  5. Braun-Menendez, E., 1958, The pro-hypertensive and anti-hypertensive actions of kidney, Ann. Int. Med. 49: 717.Google Scholar
  6. Braun-Menendez, E., and von Euler, V. S., 1947, Hypertension after bilateral nephrectomy in rat, Nature 160: 905.PubMedGoogle Scholar
  7. Bumpus, F. M., and Khosla, M. C., 1977, Pathogenic factors involved in renovascular hypertension: State of art, Mayo Clinic Proc. 52: 417.Google Scholar
  8. Carr, A. A., 1973, Effects of PGA, on renin and aldosterone in man, Prostaglandins 3: 621.PubMedGoogle Scholar
  9. Carretero, O. A., and Scicli, A. G., 1976, Renal kallikrein: Its localization and possible role in renal function, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 194.Google Scholar
  10. Colina-Chorio, J., McGiff, J. C., and Nasjletti, A., 1975, Development of high blood pressure after inhibition of prostaglandin synthesis, Fed. Proc. Fed. Am. Soc. Exp. Biol. 34: 368.Google Scholar
  11. Ducrot, H., Jungers, P., Funck-Brentano, J. L., Perrin, D., Crosnier, J., and Hamburger, J., 1966, l’Action de la transplantation renale sur l’hypertension anterielle, in: l’Hypertension Arterielle (P. Milliez and P. Tcherdakoff, eds.), Expansion Scientifique Francaise, Paris, pp. 208–222.Google Scholar
  12. Dunn, M. J., and Hood, V. J., 1977, Prostaglandins and the kidney, Am. J. Physiol. 233: F169.Google Scholar
  13. Dunn, M. J., Liard, J. F., and Dray, F., 1978, Basal and stimulated rates of renal secretion and excretion of prostaglandin E2, F and 13–14-dihydro-15-keto-F in the dog, Kidney Int. 13: 136.Google Scholar
  14. Elliot, A. H., and Nuzum, F. R., 1934, Urinary excretion of a depressor substance (Kallikrein of Frey and Kraut) in arterial hypertension, Endocrinology 18: 462.Google Scholar
  15. Fadem, S. F., Patak, R., Lifschitz, M., and Stein, J, 1977, Studies on the mechanism of increased sodium excretion during drug induced vasodilatation, Kidney Int. 12:557 (abstr.).Google Scholar
  16. Fasciolo, J. D., Houssay, B. A., and Taquini, A. C., 1938, The blood pressure raising secretion of the ischemic kidney, J. Physiol. 94: 281.PubMedGoogle Scholar
  17. Frey, E. K., and Kraut, H., 1926, Über einen von der Niere ausgeschiedenen die Herztätigkeit anregenden Stoff, Hoppe Seylers Z. Physiol. Chem. 157: 32.Google Scholar
  18. Frolich, J. C., Sweetman, B. J., Carr, K., Hollifield, J. W., and Oates, J. A., 1975a, Assess- ment of the levels of PGA, in human plasma by gas chromatography-mass spectroscopy, Prostaglandins 10:185.PubMedGoogle Scholar
  19. Frolich, J. C., Wilson, T. W., Sweetman, B. J., Smigel, M., Nies, A. S., Watson, J. T., and Oates, J. A., I975b, Urinary prostaglandins: Identification and origin, J. Clin. Invest. 55: 763.Google Scholar
  20. Goldblatt, H., Lynch, J., Hunzal, R. F., and Summerville, W. W., 1934, Studies on experimental hypertension. I. The production of persistent elevation of systolic blood pressure by renal ischemia, J. Exp. Med. 59: 347.PubMedGoogle Scholar
  21. Gomez, A. H., Hoobler, S. W., and Blaquier, P., 1960, Effects of addition and removal of kidney transplant in renal and adrenocortical hypertensive rats, Circ. Res. 8: 464.PubMedGoogle Scholar
  22. Grollman, A., 1959, Arterial hypertension of renal origin, Perspect. Biol. Med. 2: 208.PubMedGoogle Scholar
  23. Grollman, A., Williams, J. R., and Harrison, T. R., 1940, Reduction of elevated blood pressure by administration of renal extracts, J. Am. Med. Assoc. 115: 1169.Google Scholar
  24. Grollman, A., Muirhead, E. E., and Vanatta, J., 1949, Role of kidney in pathogenesis of hypertension as determined by the study of effects of bilateral nephrectomy and other procedures on the blood pressure of the dog, Am. J. Physiol. 157: 21.PubMedGoogle Scholar
  25. Grollman, A., Turner, L. B., Levitch, M., and Hill, D., 1951, Hemodynamics of the bilaterally nephrectomized dog subjected to intermittent peritoneal lavage, Am. J. Physiol. 165: 167.PubMedGoogle Scholar
  26. Hamilton, J. G., and Grollman, A., 1958, The preparation of renal extracts effective in reduc-ing blood pressure in experimental hypertension, J. Biol Chem. 233: 528.PubMedGoogle Scholar
  27. Harris, P. J., Munday, K. A., Noble, A. R., and Winch, M. N., 1973, Relationship between renin activity and concentration, Proc. Physiol. Soc. 72: 70.Google Scholar
  28. Itskovitz, H. D., and McGiff, J. C., 1974, Hormonal regulation of renal circulation, Circ. Res. 34–35–1(Suppl. 1 ): 65.Google Scholar
  29. Itskovitz, H. D., Terragno, N. A., and McGiff, J. C., 1973, Renal prostaglandins: Determinants of intrarenal distribution of blood flow, Clin. Sci. Mol. Med. 45 (Suppl. 1): 321.Google Scholar
  30. Keiser, H. R., Geller, R. G., Margolius, H. S., and Pisano, J. J., 1976a, Urinary kallikrein in hypertensive animal models, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 199.Google Scholar
  31. Keiser, H. R., Margolius, H. S., Brown, R., Rhamey, R., and Foster, J., 1976b, Urinary Kallikrein in patients with renovascular hypertension, in: Chemistry and Biology. Biology of the Kallikrein-Kinin System in Health and Disease (J. J. Pisano and K. F. Austen, eds.), U.S. Government Printing Office, Washington, D.C., pp. 423–426.Google Scholar
  32. Kolff, W. J., 1957, Reduction of experimental renal hypertension by kidney perfusion, Univ. Mich. Med. Bull. 23: 238.Google Scholar
  33. Kolff, W. J., and Page, I. H., 1954, Blood pressure reducing function of the kidney: Reduction of renoprival hypertension by kidney perfusion, Am. J. Physiol. 178: 75.PubMedGoogle Scholar
  34. Kolff, W. J., Nakamoto, S., Poutasse, E. F., Straffon, R. A., and Figeroa, J. E., 1964, Effect of bilateral nephrectomy and kidney transplantation on hypertension in man, Circulation 30 (Suppl. 2): 23.PubMedGoogle Scholar
  35. Kotchen, T. A., and Miller, M. C., 1974, Effects of prostaglandins on renin reactivity, Am. J. Physiol. 266: 314.Google Scholar
  36. Larsson, C., and Anggârd, E., 1973a, Regional differences in the formation and metabolism of prostaglandins in rabbit kidney, Eur. J. Pharmacol. 21: 30.PubMedGoogle Scholar
  37. Larsson, C., and Änggârd, E., 1973b, Archidonic acid lowers and indomethacin increases the blood pressure of the rabbit, J. Pharm. Pharmacol. 25: 653.Google Scholar
  38. Larsson, C., and Änggârd, E., 1975, Mass spectrometric determination of prostaglandins in regions of rabbit kidney, in: Proceedings of the International Congress on Prostaglandins, Florence, Italy (May 26–30), p. 179 (abstr.).Google Scholar
  39. Larsson, C., Weber, P., and Anggârd, E., 1974, Arachidonic acid increases and indomethacin decreases plasma renin activity in the rabbit, Eur. J. Pharmacol. 28: 391.PubMedGoogle Scholar
  40. Lee, J. B., 1976, The renal prostaglandins and blood pressure regulation in: Advances in Prostaglandin and Thromboxane Research, Vol. 2 (B. Samuelsson and R. Paoletti, eds.), Raven Press, New York, p. 573.Google Scholar
  41. Lee, J. B., Hickler, R. B., Saravis, C. A., and Thorn, G. W., 1962, Sustained depressor effects of renal medullary extracts, Circulation 26: 747.Google Scholar
  42. Lee, J. B., Hickler, R. B., Saravis, C. A., and Thorn, G. W., 1963, Sustained depressor effects of renal medullary extracts in the normotensive rat, Circ. Res. 13: 359.PubMedGoogle Scholar
  43. Lee, J. B., Covino, B. G., Takman, B. H., and Smith, E. R., 1965, Renomedullary vasodepressor substance medullin. Isolation, chemical characterization and physiological properties, Circ. Res. 17: 57.Google Scholar
  44. Lee, J. B., Crowshaw, K., Takman, B. H., Attrep, K. A., and Gongontas, J. Z., 1967, The identification of prostaglandins E2, F2 and A2 from rabbit kidney medulla, Biochem. J. 105: 1251.PubMedGoogle Scholar
  45. Lee, J. B., McGiff, J. C., and Kannegieser, H., 1971, Prostaglandin A,: Anti-hypertensive and renal effects, Ann. Intern. Med. 74: 703.PubMedGoogle Scholar
  46. Lee, J. B., Patak, R. V., and Mookerjee, B. K., 1976, Renal prostaglandins and the regulation of blood pressure, sodium and water homeostasis, Am. J. Med. 60: 798.PubMedGoogle Scholar
  47. Leonards, J. R., and Heisler, C. R., 1951, Hypertension of renoprival origin, Am. J. Physiol. 167: 553.PubMedGoogle Scholar
  48. Lonigro, A. J., Itskovitz, H. D., Crowshaw, K., and McGiff, J. C., 1973, Dependency of renal blood flow on prostaglandins in dog, Circ. Res. 32: 712.PubMedGoogle Scholar
  49. Lopez-Ovejero, J. A., Weber, M. A., Dryer, J. I. M., Sealey, J. E., and Largh, J. H., 1978, Effects of indomethacin alone and during diuretic or adrenoreceptor blockage therapy on blood pressure and the renin system in essential hypertension, Clin. Sci. Mol. Med. 55:203 S.Google Scholar
  50. McCaa, R. E., Hall, J. E. and McCaa, C. S., 1978, The effects of angiotensin I-converting enzyme inhibitor on arterial blood pressure and urinary sodium excretion. Role of renal renin—angiotensin and kallikrein—kinin system, Circ. Res. 43 (Suppl. 1): 32.Google Scholar
  51. McGiff, J. C., and Nasjletti, A., 1976, Kinins, renal function and blood pressure regulation, Fed. Proc. Fed. Am. Soc. Exp. Biol. 35: 172.Google Scholar
  52. McGiff, J. C., Terragno, N. A., Strand, J. C., Lee, J. B., Lonigro, A. J., and Ng, K. K. F., 1969, Selective passage of prostaglandins across the lung, Nature 223: 742.PubMedGoogle Scholar
  53. McGiff, J. C., Crowshaw, K., Terragno, N. A., and Lonigro, A. J., 1970a, Renal prosta-glandins: Possible regulators of renal actions of pressor hormones, Nature 227: 1255.PubMedGoogle Scholar
  54. McGiff, J. C., Crowshaw, K., Terragno, N. A., Lonigro, A. J., Strand, J. C., Williamson, M. A., Lee, J. B., and Ng, K. K. F., 1970b, Prostaglandin-like substance appearing in blood during renal ischemia, Circ. Res. 27: 765.Google Scholar
  55. Margolius, H. S., Geller, R. G., Pisano, J. J., and Sjordsma, A., 1971, Altered urinary kallikrein secretion in human hypertension, Lancet 2: 1063.Google Scholar
  56. Margolius, H. S., Horwitz, D., Pisano, J. J., and Keiser, H. R., 1974, Urinary Kallikrein excretion in hypertensive man. Relationship to sodium intake and to sodium retaining steroids, Circ. Res. 35: 820.PubMedGoogle Scholar
  57. Milliez, P., Meyer, Ph., Devaux, C. and Alexander, J. M., 1966, in: l’Hypertension Arterielle (P. Milliez and P. Tcherdakoff, eds.), Expansion Scientifique Francaise, Paris, pp. 203–207.Google Scholar
  58. Mitas, J. A., Levy, S. B., Holle, R., Frigon, R. P., and Stone, R. A., 1978, Urinary Kallikrein activity in hypertension of renal parenchymal disease, N. Engl. J. Med. 299: 162.PubMedGoogle Scholar
  59. Montgomery, R. G., Patel, N. C., and Lee, J. G., 1973, Comparison of diuretic effects of PGA,, sodium ethacrynate and placebo, Prostaglandins 4: 381.PubMedGoogle Scholar
  60. Muirhead, E. E., 1962, Protection against sodium overload hypertensive state, Arch. Pathol. 74: 214.PubMedGoogle Scholar
  61. Muirhead, E. E., 1976, Renomedullary anti-hypertensive endocrine function, Acta Biol. Med. Germ. 35: 1181.PubMedGoogle Scholar
  62. Muirhead, E. E., Stirman, J. A., Lesch, W., and Jones, F., 1956, The reduction of post- nephrectomy hypertension by renal homotransplants, Surg. Gynecol. Obstet. 103: 673.PubMedGoogle Scholar
  63. Muirhead, E. E., Stirman, J. A., and Jones, F., 1960, Renal autoexplantation and protection against renoprival hypertensive cardiovascular disease and hemolysis, J.Clin. Invest. 39: 266.PubMedGoogle Scholar
  64. Muirhead, E. E., Daniels, E. G., Booth, E., Freyberger, W. A., and Hinman, J. W., 1965, Renomedullary vasodepressor and anti-hypertensive function, Arch. Pathol. 80: 43.Google Scholar
  65. Muirhead, E. E., Brooks, B., Kosinsky, M., Daniels, E. G., and Hinman, J. W., 1966, Reno- medullary anti-hypertensive principle in renal hypertension, J. Lab. Clin. Med. 67: 778.PubMedGoogle Scholar
  66. Muirhead, E. E., Daniels, E. G., Pike, J. E., and Hinman, J. W., 1967, Renomedullary anti-hypertensive lipids and the prostaglandins, in: The Prostaglandins: Nobel Symposium II, Uppsala ( S. Bergstrom and B. Samuelsson, eds.), Almquist and Wiksell, Stockholm, p. 183.Google Scholar
  67. Muirhead, E. E., Leech, B. E., Byers, L. W., Daniels, E. G., and Hinman, J. W., 1971, Anti-hypertensive neutral renomedullary lipids, in: Kidney Hormones (J. W. Fisher, ed.), Academic Press, London, p. 485.Google Scholar
  68. Muirhead, E. E., Germain, G. S., Armstrong, F. B., Brooks, B., Leech, B. E., Byers, L. W., Pitcock, J. A., and Brown, P., 1975, Endocrine type anti-hypertensive function of renomedullary interstitial cells, Kidney Int. 8 (Suppl. 5): 273.Google Scholar
  69. Needleman, P., Bronson, S. D., Wyche, A., and Sinakoff, M., 1978, Cardiac and renal prostaglandin I2, J. Clin. Invest. 61: 839.PubMedGoogle Scholar
  70. Negus, P., Tannen, R. L., and Dunn, M. J., 1976, Indomethacin potentiates the vasoconstrictor actions of angiotensin II, Prostaglandins 12: 175.PubMedGoogle Scholar
  71. Olshan, A., Mitas, J., Frigon, R. P., and Stone, R. A., 1978, The influence of dietary sodium, potassium and race on urinary kallikrein activity, Kidney Int. 14:701 (abstr.).Google Scholar
  72. Orbison, J. L., Christian, C. L., and Peters, E., 1952, Studies on experimental hypertension and cardiovascular disease, Arch. Pathol. 54: 185.Google Scholar
  73. Orstavik, T. B., Nustad, K., Brandtzaeg, P., and Pierce, J. V., 1976, Cellular origin of urinary Kallikrein, J. Histochem. Cytochem. 24: 1037.Google Scholar
  74. Osmond, D. H., Smeby, R. R., and Bumpus, F. M., 1969, Quantitative studies on renin pre-inhibitor, J. Lab. Clin. Med. 73: 795.PubMedGoogle Scholar
  75. Osmond, D. H., McFadzen, P. A., and Ross, L. J., 1973, Plasma phospholipase A2 activity in nephrectomized rats and question of renin inhibitor, Proc. Soc. Exp. Biol. Med. 144: 969.PubMedGoogle Scholar
  76. Page, I. H., and Helmer, O. M., 1940, Angiotensin-activator, renin and angiotensin-inhibitor and mechanism of angiotensin tachyphylaxis in normal, hypertensive and nephrectomized animals, J. Exp. Med. 71: 495.PubMedGoogle Scholar
  77. Page, I. H., Hebner, O., Hohlstaedt, K. G., Keinff, G. F., and Corchoran, A. C., 1940, Substance in kidneys and muscle eliciting prolonged reduction in blood pressure in human and experimental hypertension, Proc. Soc. Exp. Biol. Med. 43: 722.Google Scholar
  78. Patak, R. V., Mookerjee, B. K., Bentzel, C. J., Hysert, P. E., Babej, M., and Lee, J. B., 1975, Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man, Prostaglandins 10: 649.PubMedGoogle Scholar
  79. Pierce, J. V., and Webster, M. E., 1961, Human plasma kallidins: Isolation and chemical studies, Biochem. Biophys. Res. Commun. 5: 353.Google Scholar
  80. Rocha e Silva, M., Beraldo, W. T., and Rosenfeld, G., 1949, Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin, Am. J. Physiol. 156: 261.Google Scholar
  81. Romero, J. C., Strong, C. G., Torres, V. E., Ott, C., and Knox, F. G., 1973, Plasma, prostaglandins, plasma renin activity and blood pressure in normal and renal hypertensive rab-bits treated with indomethacin, Proceedings of the 6th Annual Meeting of the American Society of Nephrology, Washington, D.C., p. 89 (abstr.).Google Scholar
  82. Rosas, R., Montaigne, D., Gross, M., and Bohr, D. R., 1965, Cardiac action of vasoactive peptides I. Bradykinin, Circ. Res. 16: 150.PubMedGoogle Scholar
  83. Scicli, A. G., Carretero, O. A., Hampton, A., Cortes, P., and Oza, N. B., 1976, Site of kininogenase secretion in the dog nephron, Am. J. Physiol. 230: 533.PubMedGoogle Scholar
  84. Scicli, A. G., Grandolfi, R., and Carretero, O. A., 1978, Site of formation of kinins in the dog nephron, Am. J. Physiol. 234: F36.PubMedGoogle Scholar
  85. Sen, S., Smeby, R. R., and Bumpus, F. M., 1967, Isolation of a phospholipid renin inhibitor from the kidney, Biochemistry 6: 1572.PubMedGoogle Scholar
  86. Sen, S., Smeby, R. R., and Bumpus, F. M., 1968, Anti-hypertensive effect of an isolated phospholipid, Am. J. Physiol. 214: 337.PubMedGoogle Scholar
  87. Sen, S., Smeby, R. R., and Bumpus, F. M., 1969, Plasma renin activity in hypertensive rats after treatment with “renin pre-inhibitor,” Am. J. Physiol. 216: 499.PubMedGoogle Scholar
  88. Shimamoto, K., Ando, T., Nakao, T., Tanaka, S., Sakuma, M., and Miyahara, M., 1978, A sensitive radioimmunoassay method for urinary kinins in man, J. Lab. Clin. Med. 91: 721.PubMedGoogle Scholar
  89. Smeby, R. R., Sen, S., and Bumpus, F. M., 1967, A naturally occurring renin inhibitor. Circ. Res. 20–21 (Suppl. 2): 129.Google Scholar
  90. Smith, W. L., and Bell, T. G., 1978, Immunohistochemical localization of the prostaglandin-forming cyclo-oxygenase in renal cortex, Am. J. Physiol. 235: F451.PubMedGoogle Scholar
  91. Stein, J. H., Ferris, T. F., Huprich, J. E., Smith, T. C., and Osgood, R. W., 1971, Effect of renal vasodilation on the distribution of cortical blood flow in the kidney of the dog, J. Clin. Invest. 50: 1429.PubMedGoogle Scholar
  92. Stein, J. H., Congbaley, R. C., Karsh, D. L., Osgood, R. W., and Ferris, T. F., 1972, The effect of bradykinin on proximal tubular sodium absorption in the dog: Evidence of functional nephron heterogeneity, J. Clin. Invest. 51: 1709.PubMedGoogle Scholar
  93. Tan, Y. S., and Murlow, P. J., 1978, Impaired renal production of prostaglandin E2: A newly identified lesion in human essential hypertension, Prostaglandins 15: 139.PubMedGoogle Scholar
  94. Terragno, N. A., Malik, K. U., Nasjletti, A., Terragno, D. A., and McGiff, J. C., 1976, Renal prostaglandins, in: Advances in Prostaglandin and Thromboxane Research, Vol. 2 (B. Samuelsson and R. Paoletti, eds.), Raven Press, New York, p. 563.Google Scholar
  95. Tigerstedt, R., and Bergman, P. G., 1898, Niere und Kreislauf, Skand, Ark. Physiol. 8: 223.Google Scholar
  96. Ward, P. E., Erdos, E. G., Gudney, C. D., Dowen, R. M., and Reynolds, R. C., 1976, Isola-tion of membrane-bound renal enzymes that metabolize kinins and angiotensins, Biochem. J. 157: 643.PubMedGoogle Scholar
  97. Weiner, R., and Kaley, G., 1969, Influence of PGEI on the terminal vascular bed, Am. J. Physiol. 217: 563.PubMedGoogle Scholar
  98. Whorton, A. R., Smigel, M., Oates, J. A., and Frohlich, J. C., 1978, Regional differences in prostacyclin formation by the kidney, Biochim. Biophys. Acta 529: 178.Google Scholar
  99. Williams, G. H., and Hollenberg, N. K., 1977, Accentuated vascular and endocrine response to SQ-20,881 in hypertension, N. Eng. J. Med. 297: 184.Google Scholar
  100. Willis, L. R., Lundens, J. H., Hook, J. B., and Williamson, H. E., 1969, Mechanism of natriuretic action of bradykinin, Am. J. Physiol. 217: 1.PubMedGoogle Scholar
  101. Wong, P. Y., McGiff, J. C., Cagan, L., Malik, K. U., and Sun, F. F., 1979, Metabolism of prostacyclin in the rabbit kidney, J. Biol. Chem. 254: 12.PubMedGoogle Scholar
  102. Zachariah, N. Y., Smeby, R. R., Sen, S., Bumpus, F. M., and Singh, C., 1975, Phospholipase A2 in experimental hypertension, Am. J. Physiol. 228: 1782.PubMedGoogle Scholar
  103. Zinner, H. S., Margolius, H. S., Rosner, B., and Kass, E. H., 1978, Stability of blood pressure rank and urinary Kallikrein concentration in childhood: An eight year follow up, Circulation 58: 908.PubMedGoogle Scholar
  104. Zins, G. R., 1975, Renal prostaglandins, Am. J. Med. 58: 14.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Basab K. Mookerjee
    • 1
    • 2
  • Ram V. Patak
    • 3
    • 4
  1. 1.State University of New York at BuffaloBuffaloUSA
  2. 2.Medical Research ServiceVeterans Administration Medical CenterBuffaloUSA
  3. 3.University of Kansas Medical CenterKansas CityUSA
  4. 4.Medical Research ServiceVeterans Administration Medical CenterKansas CityUSA

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