The Ultrastructure of the Renal Medulla and the Interstitial Cells

  • Sven-Olof Bohman


During recent years, the theory has evolved that the kidney, similar to several other organs such as the gonads and the thyroid gland, contains an interstitial cell type with endocrine functions. The cells implicated are the interstitial cells of the renal medulla, which are characterized by their content of abundant cytoplasmic lipid inclusions. The secretory product is believed to be a lipid and appears to have potent antihypertensive properties (see later chapters of this volume).


Lipid Droplet Interstitial Cell Rough Endoplasmic Reticulum Outer Zone Renal Medulla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abrahams, C., and Pirani, C. L., 1966, The renal papilla of the rat: Electronmicroscopic and histochemical studies, S. Air. J. Med. Sci. 31: 107.Google Scholar
  2. Änggârd, E., Bohman, S.-O., Griffin, J. E. III, Larsson, C., and Maunsbach, A. B., 1972, Subcellular localization of the prostaglandin system in the rabbit renal papilla, Acta Physiol. Scand. 84: 231.PubMedCrossRefGoogle Scholar
  3. Azar, S., Tobian, L., and Ishii, M., 1970, Prolonged water diuresis affecting solutes and interstitial cells of renal papilla, Am. J. Physiol. 221: 75.Google Scholar
  4. Blanchette-Mackie, E. J., and Scow, R. O., 1973, Effects of lipoprotein lipase on the structure of chylomicrons, J. Cell Biol. 58: 689.PubMedCrossRefGoogle Scholar
  5. Bohman, S.-O., 1974, The ultrastructure of the rat renal medulla as observed after improved fixation methods, J. Ultrastruct. Res. 47: 329.PubMedCrossRefGoogle Scholar
  6. Bohman, S.-O., 1977, Demonstration of prostaglandin synthesis in collecting duct cells and other cell types of the rabbit renal medulla, Prostaglandins 14: 729.PubMedCrossRefGoogle Scholar
  7. Bohman, S.-O., 1979, The interstitial cells of the renal medulla. Ultrastructure and relation to prostaglandin formation, Ph.D. thesis, University of Aarhus, Denmark.Google Scholar
  8. Bohman, S.-O., 1980, The ultrastructure and function of the interstitial cells of the renal medulla with special regard to prostaglandin synthesis, in: Functional Ultrastructure of the Kidney (A. B. Maunsbach, T. Steen Olsen, and E. I. Christensen, eds.), Academic Press, London, in press.Google Scholar
  9. Bohman, S.-O., and Jensen, P. K. A., 1976, Morphometric studies on the lipid droplets of the interstitial cells of the renal medulla in different states of diuresis, J. Ultrastruct. Res. 55: 182.PubMedCrossRefGoogle Scholar
  10. Bohman, S.-O., and Jensen, P. K. A., 1978, The interstitial cells in the renal medulla of rat, rabbit and gerbil in different states of diuresis, Cell Tissue Res. 189: 1.PubMedCrossRefGoogle Scholar
  11. Bohman, S.-O., and Maunsbach, A. B., 1969, Isolation of the lipid droplets from the interstitial cells of the renal medulla, J. Ultrastruct. Res. 29: 569.Google Scholar
  12. Bohman, S.-O., and Maunsbach, A. B., 1972, Ultrastructure and biochemical properties of subcellular fractions from rat renal medulla, J. Ultrastruct. Res. 38: 225.PubMedCrossRefGoogle Scholar
  13. Bojesen, I., 1974, Quantitative and qualitative analyses of isolated lipid droplets from interstitial cells in renal papillae from various species, Lipids 9: 835.PubMedCrossRefGoogle Scholar
  14. Bojesen, I., Bojesen, E., and Capito, K., 1976, In vitro and in vivo synthesis of long chain fatty acids from [1-“C]acetate in the renal papillae of rats, Biochim. Biophys. Acta 424: 8.PubMedGoogle Scholar
  15. Bowman, W., 1842, on the structure and use of the malpighian bodies of the kidney, with observations on the circulation through that gland, Philos. Trans. R. Soc. London B132: 57.Google Scholar
  16. Bulger, R. E., and Nagle, R. B., 1973, Ultrastructure of the interstitium in the rabbit kidney, Am. J. Anat. 136: 183.PubMedCrossRefGoogle Scholar
  17. Bulger, R. E., and Siegel, F. L., 1975, Alterations of the renal papilla during mercuric chloride-induced acute tubular necrosis, Lab. Invest. 33: 712.PubMedGoogle Scholar
  18. Bulger, R. E., and Trump, B. F., 1966, Fine structure of the rat renal papilla, Am. J. Anat. 118: 685.PubMedCrossRefGoogle Scholar
  19. Bulger, R. E., Griffith, L. D., and Trump, B. F., 1966, Endoplasmic reticulum in rat renal interstitial cells: Molecular rearrangement after water deprivation, Science 151: 83.PubMedCrossRefGoogle Scholar
  20. Bulger, R. E., Tisher, C. C., Myers, C. H., and Trump, B. F., 1967, Human renal ultrastructure. II. The thin limb of Henle’s loop and the interstitium in healthy individuals, Lab. Invest. 16: 124.PubMedGoogle Scholar
  21. Bulger, R. E., Cronin, R. E., and Dobyan, D. C., 1979, Survey of the morphology of the dog kidney, Anat. Rec. 194: 41.PubMedCrossRefGoogle Scholar
  22. Burghardt, R. C., and Andersen, E., 1979, Hormonal modulation of ovarian interstitial cells with particular reference to gap junctions, J. Cell Biol. 81: 104.PubMedCrossRefGoogle Scholar
  23. Cohn, Z. A., Hirsch, J. G., and Fedorko, M. E., 1966, The in vitro differentiation of mononuclear phagocytes. IV. The ultrastructure of macrophage differentiation in the peritoneal cavity and in culture, J. Exp. Med. 123: 747.PubMedCrossRefGoogle Scholar
  24. Cornai, K., Prose, P., Farber, S. J., and Paulsrud, J. R., 1974, Correlation of renal medullary prostaglandin content and renal interstitial cell lipid droplets, Prostaglandins 6: 375.CrossRefGoogle Scholar
  25. Cornai, K., Farber, S. J., and Paulsrud, J. R., 1975, Analyses of renal medullary lipid droplets from normal, hydronephrotic and indomethacin treated rabbits, Lipids 10: 555.CrossRefGoogle Scholar
  26. Dieterich, H. J., 1968, Die Ultrastruktur der Gefässbündel im Mark der Rattenniere, Z. Zellforsch. 84: 350.PubMedCrossRefGoogle Scholar
  27. Dousa, T. P., and Barnes, L. D., 1974, Effects of colchicine and vinblastine on the cellular action of vasopressin in mammaliam kidney. A possible role of microtubules, J. Clin. Invest. 54: 252.PubMedCrossRefGoogle Scholar
  28. Farber, S. J., Walat, R. J., Benjamin, R., and van Praag, D., 1971, Effect of increased osmo- lality on glycosaminoglycan metabolism of rabbit renal papilla, Am. J. Physiol. 220: 880.PubMedGoogle Scholar
  29. Florendo, N. T., Pitcock, J. A., and Muirhead, E. E., 1978, Cyclic 3’,5’-nucleotide phosphodiesterase; cytochemical localization in rat renomedullary interstitial cells, J. Histochem. Cytochem. 26: 441.PubMedCrossRefGoogle Scholar
  30. Fourman, J., and Moffat, D. B., 1971, The Blood Vessels of the Kidney, Blackwell, Oxford. Furusato, M., 1977, Ultrastructure and histochemistry of the medullary interstitial matrix of rat kidney, Acta Pathol. Jpn. 27: 331.Google Scholar
  31. Ginetzinsky, A. G., 1958, Role of hyaluronidase in the reabsorption of water in renal tubules: The mechanism of action of the antidiuretic hormone, Nature 182: 1218.PubMedCrossRefGoogle Scholar
  32. Gloor, F., and Neiditsch-Halff, L. A., 1965, Die interstitiellen Zellen des Nierenmarkes der Ratte, Z. Zellforsch. 66: 488.PubMedCrossRefGoogle Scholar
  33. Ishii, M., and Tobian, L., 1969, Interstitial cell granules in renal papilla and the solute com-position of renal tissue in rats with Goldblatt hypertension, J. Lab. Clin. Med. 74: 47.PubMedGoogle Scholar
  34. Johnson, F. R., and Darnton, S. J., 1967, Ultrastructural observations on the renal papilla of the rabbit, Z. Zellforsch. 81: 390.PubMedCrossRefGoogle Scholar
  35. Kaissling, B., and Kriz, W., 1979, Structural analysis of the rabbit kidney, Advances in Anatomy, Embryology, and Cell Biology, Vol. 56, Springer Verlag, Berlin, 123 pp.Google Scholar
  36. King, B. F., and Tibbits, F. D., 1977, Ultrastructural observations on cytoplasmic lamellar inclusions in oocytes of the rodent Thomomys, Anat. Rec. 189: 263.PubMedCrossRefGoogle Scholar
  37. Knepper, M. A., Danielson, R. A., Saidel, G. M., and Post, R. S., 1977, Quantitative analysis of renal medullary anatomy in rats and rabbits, Kidney Int. 12: 313.PubMedCrossRefGoogle Scholar
  38. Kokko, J. P., and Rector, F. C., 1972, Countercurrent multiplication system without active transport in inner medulla, Kidney Int. 2: 214.PubMedCrossRefGoogle Scholar
  39. Kunze, H., and Vodgt, W., 1971, Significance of phospholipase A for prostaglandin formation, Ann. N. Y. Acad. Sci. 180: 123.PubMedCrossRefGoogle Scholar
  40. Larsen, W. J., 1977, Gap junctions and hormone action, in: Transport of Ions and Water in Animals ( B. L. Gupta, R. B. Moreton, J. L. Oschman, and B. J. Wall, eds.), Academic Press, London, pp. 333–361.Google Scholar
  41. Latta, H., White, F. N., Osvaldo, L., and Johnston, W. H., 1975, Unilateral renovascular hypertension in rats. Measurements of medullary granules, juxtaglomerular granularity and cellularity and area of adrenal zones, Lab. Invest. 33: 379.PubMedGoogle Scholar
  42. Ledingham, J. M., and Simpson, F. O., 1973, Bundles of intracellular tubles in renal medullary interstitial cells, J. Cell Biol. 57: 594.Google Scholar
  43. Lee, J. B., 1973, Renal homeostasis and the hypertensive state: A unifying hypothesis, in: Prostaglandins, Vol. 1 ( P. W. Ramwell, ed.), Plenum Press, New York, pp. 133–160.Google Scholar
  44. Lee, J. B., Vance, V. K., and Cahill, G. F., Jr., 1962, Metabolism of C“-labeled substrates by rabbit kidney cortex and medulla, Am. J. Physiol. 203: 27.PubMedGoogle Scholar
  45. Lee, J. B., Crowshaw, K., Takman, B. H., Attrep, K. A., and Gougoutas, J. Z., 1967, The identification of prostaglandins E2, F2, and A2 from rabbit kidney medulla, Biochem. J. 105: 1251.PubMedGoogle Scholar
  46. Limas, C., Limas, C. J., and Gesell, M. S., 1976, Effects of indomethacin on renomedullary interstitial cells, Lab. Invest. 34: 522.PubMedGoogle Scholar
  47. Mandai, A. K., Muehrcke, R. C., Epstein, M., and Volini, F. I., 1967, Relationship of the renomedullary interstitial cells to experimental hypertension, J. Lab. Clin. Med. 70: 872.Google Scholar
  48. Mandai, A. K., Frohlich, E. D., Chrysant, K., Pfeffer, M. A., Yunice, A, and Nordquist, J. A., 1974, Ultrastructural analysis of renal papillary interstitial cell of spontaneously hypertensive rats, J. Lab. Clin. Med. 83: 256.Google Scholar
  49. Mandal, A. K., Frohlich, E. D., Chrysant, K., Nordquist, J., Pfeffer, M. A., and Clifford, M., 1975, A morphological study of the renal papillary granule: Analysis in the interstitial cell and in the interstitium, J. Lab. Clin. Med. 85: 120.Google Scholar
  50. Mandai, A. K., Nordquist, J. A., Thigpen, M. W., and James, T. M., 1979, Electron microscopy studies of papillary interstitial granules in normal human kidneys, Ann. Clin. Lab. Sci. 9: 37.Google Scholar
  51. Maunsbach, A. B., and Wirsén, C., 1966, Ultrastructural changes in kidney, myocardium and skeletal muscle of the dog during excessive mobilization of free fatty acids, J. Ultrastruct. Res. 16: 35.PubMedCrossRefGoogle Scholar
  52. Moffat, D. B., 1967a, The fine structure of the blood vessels of the renal medulla with particular reference to the control of the medullary circulation, J. Ultrastruct. Res. 19: 532.PubMedCrossRefGoogle Scholar
  53. Moffat, D. B., 1967b, A new type of cell inclusion in the interstitial cells of the medulla of the rat kidney, J. Microsc. (Paris) 6: 1073.Google Scholar
  54. Morrison, A. B., and Schneeberger-Keeley, E. E., 1969, The phagocytic role of renal medullary interstitial cells and the effect of potassium deficiency on this function, Nephron 6: 584.PubMedCrossRefGoogle Scholar
  55. Muehrcke, R. C., Rosen, S., and Volini, F. I., 1965, The interstitial cells of the renal papilla: Light and electron microscopic studies, in: Progress in Pyelonephritis ( E. H. Kass, ed.), F. A. Davis, Philadelphia, pp. 422–433.Google Scholar
  56. Muehrcke, R. C., Mandai, A. K., Epstein, M., and Volini, F. I., 1969, Cytoplasmic granularity of the renal medullary interstitial cells in experimental hypertension, J. Lab. Clin. Med. 73: 299.PubMedGoogle Scholar
  57. Muehrcke, R. C., Mandai, A. K., and Volini, F. I., 1970, A pathophysiological review of the renal medullary interstitial cells and their relationship to hypertension, Circ. Res. 26,27:I-109.Google Scholar
  58. Muirhead, E. E., Stirman, J. A., and Jones, F., 1960, Renal autoexplantation and protection against renoprival hypertensive cardiovascular disease and hemolysis, J. Clin. Invest. 39: 266.PubMedCrossRefGoogle Scholar
  59. Muirhead, E. E., Leach, B. E., Daniels, E. D., and Hinman, J. W., 1968, Lapine renomedullary lipid in murine hypertension, Arch. Pathol. 85: 72.PubMedGoogle Scholar
  60. Muirhead, E. E., Brown, G. B., Germain, G. S., and Leach, B. S., 1970, The renal medulla as an antihypertensive organ, J. Lab. Clin. Med. 76: 641.PubMedGoogle Scholar
  61. Muirhead, E. E., Brooks, B., Pitcock, J. A., Stephenson, P., and Brosius, W. L., 1972, Role of the renal medulla in the sodium-sensitive component of renoprival hypertension, Lab. Invest. 27: 192.PubMedGoogle Scholar
  62. Muirhead, E. E., Germain, G. S., Armstrong, F. B., Brooks, B., Leach, B. E., Byers, L. W., Pitcock, J. A., and Brown, P., 1975, Endocrine-type antihypertensive function of renomedullary interstitial cells, Kidney Int. 8: 271.Google Scholar
  63. Muirhead, E. E., Clapp, W. L., Pitcock, J. A., Brown, P., Brooks, B., and Brosius, W. L., 1977, Renomedullary interstitial cell (RIC) damage and the evolution of salt-dependent hypertension, Kidney Int. 12: 505.Google Scholar
  64. Nekrasova, A. A., Sokolova, R. I., and Lantsberg, L. A., 1973, Prostaglandinlike renal vasodepressor lipids and electrolyte exchange in the kidney, in: Advances in the Biosciences, Vol. 9, International Conference on Prostaglandins (S. Bergström, ed.), Pergamon Press-Vieweg, Oxford, pp. 307–312.Google Scholar
  65. Nishikawa, K., Morrison, A., and Needleman, P., 1977, Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney, J. Clin. Invest. 59: 1143.PubMedCrossRefGoogle Scholar
  66. Nissen, H. M., 1968a, On lipid droplets in renal interstitial cells. II. A histological study on the number of droplets in salt depletion and acute salt repletion, Z. Zellforsch. 85: 483.PubMedCrossRefGoogle Scholar
  67. Nissen, H. M., 1968b, On lipid droplets in renal interstitial cells. III. A histological study on the number of droplets during hydration and dehydration, Z. Zellforsch. 92: 52.PubMedCrossRefGoogle Scholar
  68. Nissen, H. M., and Andersen, H., 1968, On the localization of a prostaglandin-dehydrogenase activity in the kidney, Histochemie 14: 189.PubMedCrossRefGoogle Scholar
  69. Nissen, H. M., and Andersen, H., 1971, On the enzyme histochemistry of the renal interstitial cells, Histochemie 27: 109.PubMedCrossRefGoogle Scholar
  70. Nissen, H. M., and Bojesen, I., 1969, On lipid droplets in renal interstitial cells. IV. Isolation and identification, Z. Zellforsch. 97: 274.Google Scholar
  71. Novikoff, A. B., 1960, The rat kidney: Cytochemical and electron microscopic studies, in: Biology of Pyelonephritis (E. L. Quinn and E. H. Kass, eds.), Little, Brown, Boston, pp. 113–144.Google Scholar
  72. Osvaldo, L., and Latta, H., 1966a, The thin limbs of the loop of Henle, J. Ultrastruct. Res. 15: 144.PubMedCrossRefGoogle Scholar
  73. Osvaldo, L., and Latta, H., 1966b, Interstitial cells of the renal medulla, J. Ultrastruct. Res. 15: 589.PubMedCrossRefGoogle Scholar
  74. Osvaldo-Decima, L., 1973, Ultrastructure of the lower nephron, in: Handbook of Physiology, Section 8: Renal physiology ( J. Orloff and R. W. Berliner, eds.), American Physiological Society, Washington, D.C., pp. 81–102.Google Scholar
  75. Osvaldo-Decima, L., and Latta, H., 1970, The renal medulla of diuretic and antidiuretic rats studied by electron microscopy, in: Proceedings of the 4th International Congress of Nephrology, Vol. I ( N. Alwall, F. Berglund, and B. Josephson, eds.), Karger, Basel, pp. 116–123.Google Scholar
  76. Palade, G. E., 1959, Functional changes in the structure of cell components, in: Subcellular Particles ( T. Hayashi, ed.), Ronald Press, New York, pp. 64–83.Google Scholar
  77. Paul, J., 1965, Carbohydrate and energy metabolism, in: Cells and Tissues in Culture. Methods, Biology and Physiology, Vol. 1 ( E. N. Willmer, ed.), Academic Press, London, pp. 239–276.Google Scholar
  78. Pease, D. C., 1964, Histological Techniques for Electron Microscopy, 2nd ed., Academic Press, New York.Google Scholar
  79. Perov, Y. L., and Postnov, Y. V., 1976a, Interstitial cells of the renal medulla in rats with genetic spontaneous hypertension, Bull. Exp. Biol. Med. (USSR) 82: 938.CrossRefGoogle Scholar
  80. Perov, Y. L., and Postnov, Y. V., 1976b, Lipid droplets of interstitial medullary cells of intact rat kidney with two-kidney Goldblatt hypertension, Virchows Arch. B 22: 163.Google Scholar
  81. Pitcock, J. A., Rightsel, W. A., Brown, P., Brooks, B., and Muirhead, E. E., 1976, Functional-morphological correlates of renomedullary interstitial cells, Clin. Sci. Mol. Med. 51: 291s.Google Scholar
  82. Renaut, J., and Dubreuil, G., 1907, Note sur l’histologie, la cytologie des tubes de Bellini et le tissu conjonctif de la pyramide du rein, C. R. Assoc. Anat. 9: 94.Google Scholar
  83. Sakaguchi, H., and Suzuki, Y., 1958, Fine structure of renal tubule cells, Keizyo J. Med. 7: 17.CrossRefGoogle Scholar
  84. Salpeter, M. M., and Zilversmit, D. B., 1968, The surface coat of chylomicrons: Electron microscopy, J. Lipid Res. 9: 187.PubMedGoogle Scholar
  85. Schifferli, J., Grandchamp, A., and Chatelanat, F., 1975, Ultrastructure of the interstitial cells of the rat renal papilla, Kidney Int. 7: 366.Google Scholar
  86. Schiller, A., and Taugner, R., 1979, Junctions between interstitial cells of the renal medulla: A freeze-fracture study, Cell Tissue Res. 203: 231.PubMedCrossRefGoogle Scholar
  87. Schoefl, G. I., 1968, The ultrastructure of chylomicra and of the particles in an artificial fat emulsion, Proc. R. Soc. Ser. B 169: 147.CrossRefGoogle Scholar
  88. Schwartz, M. M., and Venkatachalam, M. A., 1974, Structural differences in thin limbs of Henle: Physiological implications, Kidney Int. 6: 193.PubMedCrossRefGoogle Scholar
  89. Schwartz, M. M., Karnovsky, M. J., and Venkatachalam, M. A., 1976, Ultrastructural differences between rat inner medullary descending and ascending vasa recta, Lab. Invest. 35: 161.PubMedGoogle Scholar
  90. Schweigger-Seidel, F., 1865, Die Nieren des Menschen and der Säugethiere in ihrem feineren Baue, Thesis, University of Halle, Halle.Google Scholar
  91. Simpson, F. O., 1970, Renal vasculature and hypertensive mechanisms, Circ. Res. 26,27:II-235.Google Scholar
  92. Sternberg, W. H., Farber, E., and Dunlap, C. E., 1956, Histochemical localization of specific oxidative enzymes: II. Localization of diphosphopyridine nucleotide and triphosphopyridine nucleotide diaphorases and the succindehydrogenase system in the kidney, J. Histochem. Cytochem. 4: 266.PubMedCrossRefGoogle Scholar
  93. Stoeckenius, W., 1962, Some electron microscopical observations on liquid crystalline phases in lipid-water systems, J. Cell. Biol. 12: 221.PubMedCrossRefGoogle Scholar
  94. Straus, W., 1971, Comparative analysis of the concentration of injected horseradish peroxidase in cytoplasmic granules of the kidney cortex, in the blood, urine and liver, J. Cell. Biol. 48: 620.PubMedCrossRefGoogle Scholar
  95. Szokol, M., Schömig, A., Thomâzy, V., and Kovacs, Z., 1979, On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension, Exp. Pathol. 17: 143.Google Scholar
  96. Thoenes, W., 1962, Fine structure of lipid granules in proximal tubule cells of mouse kidney, J. Cell Biol. 12: 433.PubMedCrossRefGoogle Scholar
  97. Tisher, C. C., 1976, Anatomy of the kidney, in: The Kidney, Vol. I (B. M. Brenner and F. C. Rector Jr., eds.), W. B. Saunders, Philadelphia, pp. 3–64.Google Scholar
  98. Tobian, L., and Azar, S., 1971, Antihypertensive and other functions of the renal papilla, Trans. Assoc. Am. Phys. 84: 281.PubMedGoogle Scholar
  99. Tobian, L,. and Ishii, M., 1969, Interstitial cell granules and solutes in renal papilla in post-Goldblatt hypertension, Am. J. Physiol. 217: 1699.Google Scholar
  100. Tobian, L., Ishii, M., and Duke, M., 1969, Relationship of cytoplasmic granules in renal papillary interstitial cells to “postsalt” hypertension, J. Lab. Clin. Med. 73: 309.PubMedGoogle Scholar
  101. Vimtrup, B. J., and Schmidt-Nielsen, B., 1952, The histology of the kidney of kangaroo rats, Anat. Rec. 114: 515.PubMedCrossRefGoogle Scholar
  102. Verberckmoes, R., van Damme, B., Clement, J., Amery, A., and Michielsen, P., 1976, Bartter’s syndrome with hyperplasia of renomedullary cells: Successful treatment with indomethacin, Kidney Int. 9: 302.PubMedCrossRefGoogle Scholar
  103. Wade, J. B., O’Neil, R. G., Pryor, J. L., and Boulpaep, E. L., 1979, Modulations of cell membrane area in renal collecting tubules by corticosteroid hormones, J. Cell Biol. 81: 439.PubMedCrossRefGoogle Scholar
  104. Zucker-Franklin, D., Grunsky, G., and Marcus, A., 1978, Transformation of monocytes into “fat” cells, Lab. Invest. 38: 620.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Sven-Olof Bohman
    • 1
  1. 1.Department of PathologyKarolinska Institute, Huddinge HospitalHuddingeSweden

Personalised recommendations