Influence of Renal Prostaglandins on Renin Release

  • Peter C. Weber
  • Wolfgang Siess


The key position of the kidney in the control of electrolyte balance and blood pressure is determined by a variety of local and systemic hormonal factors. The latter include the autonomic nervous system and catecholamines, the antidiuretic hormone (ADH), and adrenocortical hormones, and the former include the kinins, renin, and the prostaglandins (PGs), as well as other, as yet less well defined, endocrines of the kidney. Recent studies have led to new insights into the relationship between these hormonal systems and the regulation of renal blood flow, glomerular filtration rate, and the tubular handling of electrolytes. In discussing a functional relationship between PGs and the renin—angiotensin system, and the effects of PGs on electrolyte balance and blood pressure, it is necessary to consider their respective localizations within the kidney the factors causing their release, and their intrarenal and systemic actions.


Plasma Renin Activity Renal Blood Flow Renin Release Renin Secretion Renal Vascular Resistance 
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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Peter C. Weber
    • 1
  • Wolfgang Siess
    • 1
  1. 1.Department of Internal MedicineUniversity HospitalMunich 2West Germany

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