Abstract
In the past decade, there has been a virtual explosion in the number of publications dealing with the biochemistry and physiology of the prostaglandins. The recent discoveries of the thromboxanes (Hamberg et al., 1975) and of prostacyclin (Moncada et al., 1976) have added to the manifold studies of the metabolism of arachidonic acid (Fig. 1) to the prostaglandin (PG) endoperoxides PGG2 and PGH2 (Hamberg et al., 1974) and the subsequent synthesis of thromboxane A2 (TXA2) via thromboxane synthetase, an enzyme specifically inhibitable by imidazole (Needleman et al., 1976a,b, 1977a,b; of prostacyclin (PG12) via prostacyclin synthetase (Moncada et al., 1976; Needleman et al., 1977a,b), an enzyme inhibitable by 15-hydroperoxy arachidonic acid (Moncada and Vane, 1977; Needleman et al., 1978); and of PGE2 and PGF2α by isomerization and peroxidation (Karim, 1976a,b). The entire prostaglandin cascade is initiated by a cyclooxygenase that adds two molecules of oxygen to arachidonic acid, a 20-carbon polyunsaturated fatty acid (Lands et al., 1974; Flower and Vane, 1974). This cyclooxygenase enzyme is inhibited by the nonsteroidal antiinflammatory agents, such as indomethacin, ibuprofen, meclofenamic acid, and naproxen, and is specifically acetylated by acetylsalicylic acid (aspirin) (Rome and Lands, 1975; Pong and Levine, 1976; Lands and Rome, 1976).
Keywords
- Arachidonic Acid
- Phospholipase Activity
- Arachidonic Acid Release
- PGE2 Release
- Prostaglandin Biosynthesis
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Albert, W. C., and Handler, J. S., 1974, Effect of PGE1, indomethacin, and polyphloretin phosphate on toad bladder response to ADH, Am. J. Physiol. 226: 1382.
Anderson, R. S., Berl, T., McDonald, K. M., and Schrier, R. W., 1975, Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney, J. Clin. Invest. 56: 420.
Ardvino, F., Ferraz, F. P. J., and Rodrigues, J., 1966, Antidiuretic action of chlorpropamide in idiopathic diabetes insipidus, J. Clin. Endocrinol. Metab. 26: 1325.
Bartter, F. C., Pronove, P., Gill, J. R., and McCardle, R. C., 1962, Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis, Am. J. Med. 33: 811.
Bell, C., and Mya, M. K. M., 1977, Release by vasopressin of E-type prostaglandins from the rat kidney, Clin. Sci. Mol. Med. 52: 103.
Berl, T., and Schrier, R. W., 1973, Mechanism of effect of prostaglandin E, on renal water excretion, J. Clin. Invest. 52: 463.
Berl, T., Raz, A., Wald, H., Horowitz, J., and Czackes, W., 1977, Prostaglandin synthesis inhibition and the action of vasopressin: Studies in man and rat, Am. J. Physiol. 232: F529.
Bohman, S.-O., 1977, Demonstration of prostaglandin synthesis in collecting duct cells and other cell types of the rabbit renal medulla, Prostaglandins 14: 729.
Brown, C. A., Zusman, R. M., and Haber, E., 1979, Characterization of an angiotensin binding site in cultured rabbit renomedullary interstitial cells: Correlation of binding with prostaglandin synthesis, Clin. Res. 27: 501A.
Brown, C. A., Zusman, R. M. and Haber, E., 1979b, Correlation of prostaglandin biosynthesis with angiotensin binding to cultured rabbit renomedullary interstitial cells: Effects of potassium and protein synthesis inhibition, in: Proceedings of the International Conference on Prostaglandins, Washington, D.C., May 27–31, 1979, p. 14.
Brown, C. A., Zusman, R. M., and Haber, E., 1980, Characterization of an angiotensin binding site in cultured rabbit renomedullary interstitial cells: Correlation of binding with prostaglandin synthesis, Trans. Am. Assoc. Phys. 92: 169.
Chandrabose, K. A., Lapetina, E. G., Schmitges, C. J., Siegel, M. I., and Cuatrecasas, P., 1978, Action of corticosteroids in regulation of prostaglandin biosynthesis in cultured fibroblasts, Proc. Natl. Acad. Sci. USA 75: 214.
Chang, J., Lewis, G. P., and Piper, P. J., 1977, Inhibition by glucocorticoids of prostaglandin release from adipose tissue in vitro, Br. J. Pharm. 59: 425.
Crowshaw, K., McGiff, J. C., Strand, J. C., Lonigro, A. J., and Terragno, N. A., 1970, Prostaglandins in dog renal medulla, J. Pharm. Pharmacol. 22: 302.
Danon, A., Knapp, H. R., Oelz, O., and Oates, J. A., 1978, Stimulation of prostaglandin biosynthesis in the renal papilla by hypertonic mediums, Am. J. Physiol. 234: F64.
Dunn, M. J., and Hood, V. L., 1977, Prostaglandins and the kidney, Am. J. Physiol. 233: F169.
Dunn, M. J., Staley, R. S., and Harrison, M., 1976, Characterization of prostaglandin production in tissue culture of rat renal medullary cells, Prostaglandins 12: 37.
Dunn, M. J., Greeley, H. P., Homer, J., and Valtin, H., 1977, Renal excretion of prostaglandin E2 and F2,, in Brattleboro homozygous diabetes insipidus rats, Kidney Int. 12: 555.
Dunn, M. J., Greeley, H. P., Valtin, H., Kinter, L. B., and Beewkes, R., 1978, Renal excretion of prostaglandins E2 and F2. in diabetes insipidus rats, Am. J. Physiol. 235: E624.
Egan, R. W., Paxton, J., and Kuehl, F. A., 1976, Mechanism for irreversible self-deactivation of prostaglandin synthetase, J. Biol. Chem. 251: 7329.
Fichman, M. P., Telfer, N., Zia, P., Speckart, P., Golub, M. and Rude, R., 1976, Role of prostaglandins in the pathogenesis of Bartter’s syndrome, Am. J. Med. 60: 785.
Floman, Y., and Zor, U., 1976, Mechanism of steroid action in inflammation: Inhibition of prostaglandin synthesis and release, Prostaglandins 12: 403.
Flores, A. G. A., and Sharp, G. W. G., 1972, Endogenous prostaglandins and osmotic water flow in the toad bladder, Am. J. Physiol. 223: 1392.
Flower, R. J., and Vane, J. R., 1974, Inhibition of prostaglandin biosynthesis, Biochem. Pharmacol. 23: 1439.
Frolich, J. C., Wilson, T. W., Sweetman, B. J., Siegal, M., Nies, A. S., Carr, K., Watson, J. T., and Oates, J. A., 1975, Urinary prostaglandins: Identification and origin, J. Clin. Invest. 55: 763.
Galvez, O. G., Bay, W., Roberts, B. W., and Ferris, T. F., 1977, The hemodynamic effects of potassium deficiency in the dog, Circ. Res. 40 (Suppl. I): 1–11.
Gill, J. R., and Bartter, F. C., 1978, Evidence for a prostaglandin-independent defect in chloride reabsorption in the loop of Henle as a proximal cause of Bartter’s syndrome, Am. J. Med. 65: 766.
Gill, J. R., Frolich, J. C., Bowden, R. E., Taylor, A. A., Keiser, H. R., Seyberth, H. W., Oates, J. A., and Bartter, F. C., 1976, Bartter’s syndrome: A disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis, Am. J. Med. 61: 43.
Grantham, J. J., and Orloff, J., 1968, Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3’,5’-monophosphate and theophylline, J. Clin. Invest. 47: 1154.
Gryglewski, R. J., 1976, Steroid hormones, anti-inflammatory steroids, and prostaglandins, Pharmacol. Res. Comm. 8: 337.
Gullner, H.-G., Gill, J. R., Bartter, F. C., and Chan, J. C. M., 1979, A familial disorder with hypokalemic alkalosis, hyperreninemia, aldosteronism and high prostaglandins that is not Bartter’s syndrome, Clin. Res. 27: 520A.
Haggitt, R. C., Pitcock, J. A., and Muirhead, E. E., 1971, Renal medullary fibrosis in hypertension, Hum. Pathol. 2: 587.
Hamberg, M., Svensson, J., and Samuelson, B., 1974, Prostaglandin endoperoxides: A new concept concerning the mode of action and release of prostaglandins, Proc. Natl. Acad. Sci. USA 71: 3824.
Hamberg, M., Svensson, J., and Samuelson, B., 1975, Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. USA 72: 2994.
Handler, J. S., and Orloff, J., 1973, The mechanism of action of antidiuretic hormone, in: The Handbook of Physiology: Section 8: Renal Physiology ( J. Orloff and R. Berliner, eds.), American Physiological Society, Washington, D.C., pp. 791–814.
Hassid, A., Konieczkowski, M., and Dunn, M. J., 1979, Prostaglandin synthesis in isolated rat renal glomeruli, Proc. Natl. Acad. Sci. USA 76: 1155.
Hong, S. L., and Levine, L., 1976, Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanisms of action on MC5–5 fibroblasts, J. Biol. Chem. 251: 5814.
Janszen, F. H. A., and Nugteren, D. H., 1971, Histochemical localization of prostaglandin synthetase, Histochemie 27: 159.
Kantrowitz, F., Robinson, D. R., McGuire, M. B., and Levine, L., 1975, Corticosteroids inhibit prostaglandin production by rheumatoid synovia, Nature 258: 737.
Karim, S. M. M. (ed.), 1976a, Prostaglandins: Chemical and Biochemical Aspects, University Park Press, Baltimore.
Karim, S. M. M. (ed.), 1976b, Prostaglandins: Physiological, Pharmacological, and Pathological Aspects, University Park Press, Baltimore.
Lands, W. E. M., and Rome, L. H., 1976, Inhibition of prostaglandin biosynthesis, in: Prostaglandins: Chemical and Biochemical Aspects ( S. M. M. Karim, ed.), University Park Press, Baltimore, pp. 87–138.
Lands, W. E. M., leTellier, P. R., Rome, L., and Vanderhoek, J. Y., 1974, Regulation of prostaglandin synthesis, in: Prostaglandin Synthetase Inhibitors ( H. J. Robinson and J. R. Vane, eds.), Raven Press, New York, pp. 1–7.
Lerman, R. J., Pitcock, J. A., Stephenson, P., and Muirhead, E. E., 1972, Renomedullary insterstitial cell tumor (formerly fibroma of renal medulla), Hum. Pathol. 3: 559.
Lewis, G. P., and Piper, P. J., 1975, Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids, Nature 254: 308.
Lifschitz, M. D. and Stein, J. H., 1977, Antidiuretic hormone stimulated renal prostaglandin E synthesis in the rabbit, Clin. Res. 25: 440A.
Lipson, L. C., and Sharp, G. W. G., 1971, Effect of prostaglandin E, on sodium transport and osmotic water flow in the toad bladder, Am. J. Physiol. 220: 1046.
Lipson, L., Hynie, S., and Sharp, G., 1971, Effect of prostaglandin E, on osmotic water flow and sodium transport in the toad bladder, Ann. N.Y. Acad. Sci. 180: 261.
Lum, H. M., Aisenberg, G. A., Dunn, M. J., Berl, T., Schrier, R. W., and McDonald, K. M., 1977, In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin, J. Clin. Invest. 58: 8.
McGiff, J. C., and Malik, K. U., 1976, Renal prostaglandins, in: Prostaglandins: Physiological, Pharmacological, and Pathological Aspects ( S. M. M. Karim, ed.), University Park Press, Baltimore, pp. 201–246.
Martin, M. R., and Tiltman, A. J., 1976, Incidence of renomedullary interstitial cell tumors and correlation with hypertension, S. Afr. Med. J. 50: 2099.
Moncada, S., and Vane, J. R., 1977, The discovery of prostacyclin (PGX): A fresh insight into arachidonic acid metabolism, in: Intersciences Prostaglandin Symposium, Academic Press, New York, pp. 155–178.
Moncada, S., Gryglewski, R., Bunting, S., and Vane, J. R., 1976, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation, Nature 264: 633.
Morrison, A. R., Nishikawa, K., and Needleman, P., 1977, Unmasking of thromboxane A2 synthesis by ureteral obstruction in the rabbit kidney, Nature 267: 259.
Moses, A. M., Numan, P., and Miller, M., 1973, Mechanism of chlorpropamide-induced anti-diuresis in man: Evidence for release of ADH and enhancement of peripheral action, Metab. Clin. Exp. 22: 59.
Muirhead, E. E., Germain, G., Leach, B. E., Pitcock, J. A., Stephenson, P., Brooks, B., Brosius, W. L., Daniels, E. G., and Hinman, J. W., 1972, Production of renomedullary prostaglandins by renomedullary interstitial cells grown in tissue culture, Circ. Res. 30–31 (Suppl. II): 11–161.
Needleman, P., Minkes, M., and Raz, A., 1976a, Thromboxanes: Selective biosynthesis and distinct biological properties, Science 193: 163.
Needleman, P., Moncada, S., Bunting, S., Vane, J. R., Hamberg, M., and Samuelsson, B., 1976b, Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides, Nature 261: 558.
Needleman, P., Raz, A., Ferrendelli, J. A., and Minkes, M., 1977a, Application of imidazole as a selective inhibitor of thromboxane synthetase in human platelets, Proc. Natl. Acad. Sci. USA 74: 1716.
Needleman, P., Raz, A., Kulkaeni, S., Pure, E., Wyche, A., Denny, S. E., and Isakson, P. C., 1977b, Biological and chemical characterization of a unique endogenous vasodilator prostaglandin produced in isolated coronary artery and in intact perfused heart, in: Interscience Symposium on Prostaglandins, Academic Press, New York, pp. 199–215.
Needleman, P., Bronson, S. D., Wyche, A., Sivakoff, M., and Nicolaou, K. C., 1978, Cardiac and renal prostaglandin I2: Biosynthesis and biological effects in isolated perfused rabbit tissues, J. Clin. Invest. 61: 839.
Norby, L., Flamenbaum, W., Lentz, R., and Ramwell, P. W., 1976, Prostaglandins and aspirin therapy in Bartter’s syndrome, Lancet 2: 604.
Omachi, R. S., Robbie, D. E., Handler, J. S., and Orloff, J., 1974, Effect of ADH and other agents on cyclic AMP accumulation in toad bladder epithelium, Am. J. Physiol. 226: 1152.
Orloff, J., and Zusman, R., 1978, The role of prostaglandin E (PGE) in the modulation of the action of vasopressin on water flow in the urinary bladder of the toad and mammalian kidney, J. Membr. Biol. 40: 297.
Orloff, J., Handler, J. S., and Bergstrom, S., 1965, Effect of prostaglandin (PGE,) on the permeability response of toad bladder to vasopressin, theophylline and adenosine 3’,5’monophosphate, Nature 205: 397.
Ozer, A., and Sharp, G. W. G., 1972, Effect of prostaglandins and their inhibitors on osmotic water flow in the toad bladder, Am. J. Physiol. 222: 674.
Pong, S., and Levine, L., 1976, Prostaglandin synthetase systems of rabbit tissues and their inhibition by non-steroidal anti-inflammatory drugs, J. Pharmacol. Exp. Ther. 196: 226.
Pong, S., Hong, S. L., and Levine, L., 1977, Prostaglandin production by methycholanthrene-transformed mouse BALB/3T3: Requirement for protein synthesis, J. Biol. Chem. 252: 1408.
Preszyna, A., Attalah, A., Vance, V. K., Schoolman, M., and Lee, J. B., 1973, The renomedullary body: A newly recognized structure of renomedullary interstitial cell origin associated with high prostaglandin content, Prostaglandins 3: 669.
Ramwell, P. W., and Daniels, E. G., 1969, Chromatography of prostaglandins, in: Lipid Chromatographic Analysis ( G. V. Marinetti, ed.), Marcel Dekker, New York, pp. 313–344.
Reese, A. J. M., and Winstanley, D. P., 1958, The small tumor-like lesions of the kidney, Br. J. Cancer 12: 507.
Rome, L. H., and Lands, W. E. M., 1975, Structural requirements for time dependent inhibition of prostaglandin biosynthesis by antiinflammatory drugs, Proc. Natl. Acad. Sci. USA 72: 4863.
Smith, W. L., and Bell, T. G., 1978, Immunohistochemical localization of the prostaglandin forming cyclo-oxygenase in renal cortex, Am. J. Physiol. 235: F451.
Stuart, R., Salyer, W. R., Salyer, D. C., and Heptinstall, R. H., 1976, Renomedullary interstitial cell lesions and hypertension, Hum. Pathol. 7: 327.
Tashjian, A. H., Jr., Voelkel, E. F., McDonough, J., and Levin, L., 1975, Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells, Nature 258: 739.
Tobian, L., and Azar, S., 1971. Antihypertensive and other functions of the renal papilla, Trans. Assoc. Am. Phys. 84: 281.
Urakabe, S., Taksmitsu, Y., Shirai, D., Yuasa, S., Kimura, G., Orita, Y., and Abem H., 1975, Effect of different prostaglandins on the permeability of the toad urinary bladder, Comp. Biochem. Physiol. 52: 1.
Vargaftig, B. B., and Hai, N. D., 1972, Selective inhibition by mepacrine of the release of “rabbit aorta contracting substance” evoked by the administration of bradykinin, J. Pharm. Pharmacol. 24: 159.
Verbeckmoes, R., Van Damme, B., Clement, J., Amery, A. and Michielsen, P., 1976, Bartter’s syndrome with hyperplasia of renomedullary cells. Successful treatment with indomethacin, Kidney Int. 9: 302.
Vinci, J. M., Gill, J. R., Bowden, R. E., Pisano, J. J., Izzo, J. L., Radfar, N., Taylor, A. A., Zusman, R. M., Bartter, F. C., and Keiser, H. R., 1978, Kallikrein-kinin system and its response to prostaglandin synthesis inhibition, J. Clin. Invest. 61: 1671.
Walker, L. A., Whorton, A. R., Siegel, M., France, R. and Frolich, J. C., 1978, Antidiuretic hormone increases renal prostaglandin synthesis in vivo, Am. J. Physiol. 235:F180.
Zusman, R. M., 1980, Regulation of prostaglandin biosynthesis: Studies in the rabbit renomedullary interstitial cell and the toad urinary bladder in vitro, in: Prostaglandins in Cardiovascular and Renal Physiology (A. Scriabine, ed. ), Spectrum Publications, pp. 93–121.
Zusman, R. M., and Brown, C. A., 1979, Role of phospholipase in the regulation of prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Effects of angiotensin II, potassium, dexamethasone, hyperosmolality and inhibition of protein synthesis, in: Proceedings of the International Conference on Prostaglandins, Washington, D.C., May 27–31, 1979, p. 130.
Zusman, R. M., and Brown, C. A., 1980, Role of phospholipase in the regulation of prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Effects of angiotensin II, potassium, dexamethane, hyperosmolality and inhibition of protein synthesis, in: Advances in Prostaglandin and Thromboxane Research, Vol. 6 ( P. Ramwell, ed.), Raven Press, New York, p. 243.
Zusman, R. M., and Keiser, H. R., 1977a, Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Stimulation by angiotensin II, bradykinin and arginine vasopressin, J. Clin. Invest. 60: 215.
Zusman, R. M., and Keiser, H. R., 1977b, Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Mechanism of stimulation by angiotensin II, bradykinin, and arginine vasopressin, J. Biol. Chem. 252: 2069.
Zusman, R. M., and Keiser, H. R., 1980, Regulation of prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture: Effects of potassium, osmolality, corticosteroids, arachidonic acid, and protein synthesis inhibition, Kidney Int. 17: 277.
Zusman, R. M., Keiser, H. R. and Handler, J. S., 1977a, Vasopressin-stimulated prostaglandin E biosynthesis in the toad urinary bladder: Effect on water flow, J. Clin. Invest. 60: 1339.
Zusman, R. M., Keiser, H. R., and Handler, J. S., 1977b, Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder: Mechanism of enhancement of vasopressin-stimulated water flow, J. Clin. Invest. 60: 1348.
Zusman, R. M., Keiser, H. R., and Handler, J. S., 1977c, A hypothesis for the molecular mechanism of action of chlorpropamide in the treatment of diabetes mellitus and diabetes insipidus, Fed. Proc. Fed. Am. Soc. Exp. Biol. 13: 2728.
Zusman, R. M., Keiser, H. R., and Handler, J. S., 1978, Effect of adrenal steroids on vasopressin-stimulated PGE synthesis and water flow, Am. J. Physiol. 234: F532.
Zusman, R. M., Vinci, J. M., Bowden, R. E., Horwitz, D., and Keiser, H. R., 1979, The effect of indomethacin and adrenocorticotrophic hormone on renal function in man: An experimental model of inappropriate antidiuresis, Kidney Int. 15: 62.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Plenum Publishing Corporation
About this chapter
Cite this chapter
Zusman, R.M. (1980). Prostaglandin E2 Biosynthesis by Renomedullary Interstitial Cells. In: Mandal, A.K., Bohman, SO. (eds) The Renal Papilla and Hypertension. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8115-0_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8115-0_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8117-4
Online ISBN: 978-1-4684-8115-0
eBook Packages: Springer Book Archive